Optimizing antibiotic prescribing for acutely ill children in primary care (ernie2 study protocol, part b): A cluster randomized, Factorial controlled trial evaluating the effect of a point-of-care c-reactive protein test and a brief intervention combined with written safety net advice

BMC Pediatrics

Volumn 14, Issue 1, 2014, Pages 1-9

  Lemiengre, Marieke ^d   Verbakel, Jan ^d   Burghgraeve, Tine De ^b   Aertgeerts, Bert ^b   Baets, Frans De ^c   Buntinx, Frank ^b,d   Sutter, An De ^a   Bullens, Dominique ^d   De Baets, Frans ^d   De Burghgraeve, Tine ^d   Decaestecker, Karin ^d   De Schynkel, Katrien ^d   De Sutter, An ^d   Logghe, Karl ^d   Leus, Jasmine ^d   Pattyn, Luc ^d   Raes, Marc ^d   Van den Berghe, Lut ^d   Van Geet, Christel ^d  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c GHENT UNIVERSITY HOSPITAL   (Belgium)

^d MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Acute disease; Anti bacterial agents economics ; Anti bacterial agents therapeutic use; C reactive protein analysis; Child; Cluster analysis; Communication; Infant; Parent satisfaction; Physician's practice patterns; Point of care systems

Indexed keywords

ANTIBIOTIC AGENT; C REACTIVE PROTEIN; ANTIINFECTIVE AGENT;

ACUTE DISEASE; ADOLESCENT; ANTIBIOTIC RESISTANCE; ANXIETY; ARTICLE; CHILD; CHILD HEALTH CARE; CLUSTER ANALYSIS; COMMUNICATION SKILL; CONFUSION (UNCERTAINTY); CONSULTATION; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DIAGNOSTIC TEST; DOCTOR PATIENT RELATION; DRUG SAFETY; FACTORIAL DESIGN; FOLLOW UP; GENERAL PRACTICE; GENERAL PRACTITIONER; HEALTH CARE COST; HEALTH CARE UTILIZATION; HUMAN; INAPPROPRIATE PRESCRIBING; INFANT; MAJOR CLINICAL STUDY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PARENT COUNSELING; PARENTAL ATTITUDE; PARENTAL SATISFACTION; POINT OF CARE TESTING; PRESCRIPTION; PRIMARY MEDICAL CARE; PROTEIN ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SATISFACTION; BELGIUM; CLINICAL PRACTICE; HEALTH SERVICE; HUMAN RELATION; INTERPERSONAL COMMUNICATION; PARENT; PATIENT EDUCATION; PATIENT SATISFACTION; POINT OF CARE SYSTEM; PREVENTION AND CONTROL; PRIMARY HEALTH CARE; PSYCHOLOGY; PUBLICATION; STATISTICS AND NUMERICAL DATA; UTILIZATION;

ACUTE DISEASE; ANTI-BACTERIAL AGENTS; ANXIETY; BELGIUM; C-REACTIVE PROTEIN; CHILD; COMMUNICATION; DRUG PRESCRIPTIONS; HEALTH SERVICES; HUMANS; INAPPROPRIATE PRESCRIBING; PAMPHLETS; PARENTS; PATIENT EDUCATION AS TOPIC; PATIENT SATISFACTION; POINT-OF-CARE SYSTEMS; PRACTICE PATTERNS, PHYSICIANS'; PRIMARY HEALTH CARE; PROFESSIONAL-FAMILY RELATIONS;

EID: 84928709913     PISSN: None     EISSN: 14712431     Source Type: Journal    
DOI: 10.1186/1471-2431-14-246     Document Type: Article

References (39)

1. Van den Bruel A, Bartholomeeusen S, Aertgeerts B, Truyers C, Buntinx F: Serious infections in children: an incidence study in family practice. BMC family practice 2006, 7:23.
2. Truyers C, Goderis G, Dewitte H, Akker MV, Buntinx F: The Intego database: background, methods and basic results of a Flemish general practice-based continuous morbidity registration project. BMC Med Inform Decis Mak 2014, 14(1):48.
3. Coenen S, Van Royen P, Vermeire E, Hermann I, Denekens J: Antibiotics for coughing in general practice: a qualitative decision analysis. Fam Pract 2000, 17(5):380-385.
4. Mainous AG 3rd, Hueston WJ, Love MM: Antibiotics for colds in children: who are the high prescribers? Arch Pediatr Adolesc Med 1998, 152(4):349-352.
5. McIsaac WJ, Goel V, To T, Low DE: The validity of a sore throat score in family practice. CMAJ 2000, 163(7):811-815.
6. Murray S, Del Mar C, O'Rourke P: Predictors of an antibiotic prescription by GPs for respiratory tract infections: a pilot. Fam Pract 2000, 17(5):386-388.
7. Roland D, Jones C, Neill S, Thompson M, Lakhanpaul M: Safety netting in healthcare settings: what it means, and for whom? Arch Dis Child Educ Pract Ed 2014, 99(2):48-53.
8. Kai J: Parents' difficulties and information needs in coping with acute illness in preschool children: a qualitative study. BMJ (Clinical research ed) 1996, 313(7063):987-990.
9. Palmer DA, Bauchner H: Parents' and physicians' views on antibiotics. Pediatrics 1997, 99(6):E6.
10. Britten N, Ukoumunne O: The influence of patients' hopes of receiving a prescription on doctors' perceptions and the decision to prescribe: a questionnaire survey. BMJ (Clinical research ed) 1997, 315(7121):1506-1510.
11. Cockburn J, Pit S: Prescribing behaviour in clinical practice: patients' expectations and doctors' perceptions of patients' expectations-a questionnaire study. BMJ (Clinical research ed) 1997, 315(7107):520-523.
12. Coenen S, Michiels B, Renard D, Denekens J, Van Royen P: Antibiotic prescribing for acute cough: the effect of perceived patient demand. Br J Gen Pract 2006, 56(524):183-190.
13. Bauchner H, Pelton SI, Klein JO: Parents, physicians, and antibiotic use. Pediatrics 1999, 103(2):395-401.
14. Watson RL, Dowell SF, Jayaraman M, Keyserling H, Kolczak M, Schwartz B: Antimicrobial use for pediatric upper respiratory infections: reported practice, actual practice, and parent beliefs. Pediatrics 1999, 104(6):1251-1257.
15. Cabral C, Ingram J, Hay AD, Horwood J: "They just say everything's a virus"-parent's judgment of the credibility of clinician communication in primary care consultations for respiratory tract infections in children: a qualitative study. Patient Educ Couns 2014, 95(2):248-253.
16. Kai J: What worries parents when their preschool children are acutely ill, and why: a qualitative study. BMJ (Clinical research ed) 1996, 313(7063):983-986.
17. Verbakel JY, Lemiengre MB, De Burghgraeve T, De Sutter A, Bullens DMA, Aertgeerts B, Buntinx F, on behalf of the ERNIE2 collaboration: Diagnosing serious infections in acutely ill children in ambulatory care (ERNIE 2 study protocol part A): diagnostic accuracy of a Clinical Decision Tree and added value of a Point-of-Care C-reactive protein Test and Oxygen Saturation. BMC Pediatrics 2014, 14:207.
18. Campbell MK, Piaggio G, Elbourne DR, Altman DG: Consort 2010 statement: extension to cluster randomised trials. BMJ (Clinical research ed) 2012, 345:e5661.
19. Harnden A: Recognising serious illness in feverish young children in primary care. BMJ (Clinical research ed) 2007, 335(7617):409-410.
20. Meremikwu MM, Oyo-Ita A: Paracetamol versus placebo or physical methods for treating fever in children. Cochrane Database of Systematic Reviews 2002, (Issue 2). Art. No.: CD003676. doi:10.1002/14651858.CD003676.
21. Meremikwu MM, Oyo-Ita A: Physical methods versus drug placebo or no treatment for managing fever in children. Cochrane Database of Systematic Reviews 2003, (Issue 2). Art. No.: CD004264. doi:10.1002/14651858.CD004264.
22. Richardson M, Lakhanpaul M: Assessment and initial management of feverish illness in children younger than 5 years: summary of NICE guidance. BMJ (Clinical research ed) 2007, 334(7604):1163-1164.
23. van den Anker JN: Optimising the management of fever and pain in children. Int J Clin Pract Suppl 2013, 178:26-32.
24. Verbakel JY, Van den Bruel A, Thompson M, Stevens R, Aertgeerts B, Oostenbrink R, Moll HA, Berger MY, Lakhanpaul M, Mant D, Frank B, the European Research Network on Recognising Serious Infection (ERNIE): How well do clinical prediction rules perform in identifying serious infections in acutely ill children across an international network of ambulatory care datasets? BMC Med 2013, 11:10.
25. Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW: Combined and alternating paracetamol and ibuprofen therapy for febrile children. Cochrane Database of Systematic Reviews 2013, (Issue 10). Art. No.: CD009572. doi:10.1002/14651858.CD009572.pub2.
26. Grol R, Whitfield M, De Maeseneer J, Mokkink H: Attitudes to risk taking in medical decision making among British, Dutch and Belgian general practitioners. Br J Gen Pract 1990, 40(333):134-136.
27. Hart CN, Drotar D, Gori A, Lewin L: Enhancing parent-provider communication in ambulatory pediatric practice. Patient Educ Couns 2006, 63(1-2):38-46.
28. Seid M, Varni JW, Bermudez LO, Zivkovic M, Far MD, Nelson M, Kurtin PS: Parents' Perceptions of Primary Care: measuring parents' experiences of pediatric primary care quality. Pediatrics 2001, 108(2):264-270.
29. Lewis CC, Scott DE, Pantell RH, Wolf MH: Parent satisfaction with children's medical care. Development, field test, and validation of a questionnaire. Med Care 1986, 24(3):209-215.
30. SJ P: Clinical trials. A practical approach. Chichester: J Wiley & Sons; 1983.
31. Campbell MK, Thomson S, Ramsay CR, MacLennan GS, Grimshaw JM: Sample size calculator for cluster randomized trials. Comput Biol Med 2004, 34(2):113-125.
32. Thompson DM, Fernald DH, Mold JW: Intraclass correlation coefficients typical of cluster-randomized studies: estimates from the Robert Wood Johnson Prescription for Health projects. Ann Fam Med 2012, 10(3):235-240.
33. Campbell M, Grimshaw J, Steen N: Sample size calculations for cluster randomised trials. Changing Professional Practice in Europe Group (EU BIOMED II Concerted Action). J Health Serv Res Policy 2000, 5(1):12-16.
34. Soler JK, Okkes I, Wood M, Lamberts H: The coming of age of ICPC: celebrating the 21st birthday of the International Classification of Primary Care. Fam Pract 2008, 25(4):312-317.
35. WHO Collaborating Centre for Drug Statistics Methodology: Guidelines for ATC classification and DDD assignment, 2014. Oslo: Oslo; 2013.
36. Arnold SR, Straus SE: Interventions to improve antibiotic prescribing practices in ambulatory care. Cochrane Database of Systematic Reviews 2005, (Issue 4). Art. No.: CD003539. doi:10.1002/14651858.CD003539.pub2.
37. Huang Y, Chen R, Wu T, Wei X, Guo A: Association between point-of-care CRP testing and antibiotic prescribing in respiratory tract infections: a systematic review and meta-analysis of primary care studies. Br J Gen Pract 2013, 63(616):e787-794.
38. Cals JW, Butler CC, Hopstaken RM, Hood K, Dinant GJ: Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: cluster randomised trial. BMJ (Clinical research ed) 2009, 338:b1374.
39. Francis NA, Butler CC, Hood K, Simpson S, Wood F, Nuttall J: Effect of using an interactive booklet about childhood respiratory tract infections in primary care consultations on reconsulting and antibiotic prescribing: a cluster randomised controlled trial. BMJ (Clinical research ed) 2009, 339:b2885.