Combined and alternating paracetamol and ibuprofen therapy for febrile children

Cochrane Database of Systematic Reviews

Volumn 2013, Issue 10, 2013, Pages

  Wong, Tiffany ^a,b   Stang, Antonia S ^c   Ganshorn, Heather ^d   Hartling, Lisa ^e   Maconochie, Ian K ^f   Thomsen, Anna M ^b   Johnson, David W ^d  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ALBERTA CHILDREN'S HOSPITAL   (Canada)

^c UNIVERSITY OF CALGARY   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

^e UNIVERSITY OF ALBERTA   (Canada)

^f ST MARY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

IBUPROFEN; PARACETAMOL; ANTIPYRETIC AGENT;

BODY TEMPERATURE; CAREGIVER; CHILD HEALTH CARE; CLINICAL PRACTICE; DISEASE ASSOCIATION; DOSAGE SCHEDULE COMPARISON; DRUG EFFICACY; DRUG SAFETY; EVIDENCE BASED MEDICINE; FEVER; HUMAN; INTERMETHOD COMPARISON; MONOTHERAPY; PRIORITY JOURNAL; REVIEW; SYMPTOMATOLOGY; SYSTEMATIC REVIEW; TREATMENT RESPONSE; CHILD; DRUG EFFECTS; META ANALYSIS; MULTIMODALITY CANCER THERAPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); TIME; DRUG EFFECT; METHODOLOGY;

ACETAMINOPHEN; ANTIPYRETICS; BODY TEMPERATURE; CHILD; COMBINED MODALITY THERAPY; FEVER; HUMANS; IBUPROFEN; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TIME FACTORS;

EID: 84892466370     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD009572.pub2     Document Type: Review

References (60)

1. Erlewyn-Lajeunesse MD, Coppens K, Hunt LP, Chinnick PJ, Davies P, Higginson I M, et al.Randomised controlled trial of combined paracetamol and ibuprofen for fever. Archives of Disease in Childhood 2006;91(5):414-6.
2. Hay AD, Costelloe C, Redmond NR, Montgomery AA, Fletcher M, Hollinghurst S, et al.Paracetamol and ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. British Medical Journal 2008;337:a1302.
3. Kramer LC, Richards PA, Thompson AM, Harper DP, Fairchok MP. Alternating antipyretics: antipyretic efficacy of acetaminophen versus acetaminophen alternated with ibuprofen in children. Clinical Pediatrics 2008;47(9):907-11.
4. Nabulsi M, Tamim H, Mahfoud Z, Itani M, Sabra R, Chamseddine F, et al.Alternating ibuprofen and acetaminophen in the treatment of febrile children: a pilot study. BMC Medicine 2006;4(4):b3540.
5. Paul IM, Sturgis SA, Yang C, Engle L, Watts H, Berlin CM Jr. Efficacy of standard doses of ibuprofen alone, alternating, and combined with acetaminophen for the treatment of febrile children. Clinical Therapeutics 2010;32(14):2433-40.
6. Sarrell EM, Wielunsky E, Cohen HA. Antipyretic treatment in young children with fever: acetaminophen, ibuprofen, or both alternating in a randomized, double-blind study. Archives of Pediatrics & Adolescent Medicine 2006;160(2):197-202.
7. Del Vecchio MT, Sundel ER. Alternating antipyretics: Is this an alternative?. Pediatrics 2001;108(5):1236-7.
8. Diez Domingo J, Burgos Ramirez A, Garrido Garcia J, Ballester Sanz A, Moreno Carretero E. Use of alternating antipyretics in the treatment of fever in Spain [Utilizacion de la alternancia de antipireticos en el tratamiento de la fiebre en Espana]. Anales Espanoles de Pediatria December 2001;55(6):503-10.
9. Drucker R. Comparison of acetaminophen, ibuprofen, and both agents for treatment of fever in children acetaminophen plus ibuprofen and ibuprofen alone are equally effective in reducing fever. Archives of Disease in Childhood 2009;94(1):30.
10. Lal A, Gomber S, Talukdar B. Antipyretic effects of nimesulide, paracetamol and ibuprofen-paracetamol. Indian Journal of Pediatrics 2000;67(12):865-70.
11. Malik K, Goldman RD. PRETx update: Alternating antipyretics in febrile children. International Pediatrics 2007;22(2):95-7.
12. Mayoral CC, Marino RV, Rosenfeld W, Greensher J. Alternating antipyretics: Is this an alternative?. Pediatrics 2000;105(5):1009-12.
13. Miller AA. Alternating acetaminophen with ibuprofen for fever: Is this a problem?. Pediatric Annals 2007;36(7):384-6.
14. Nabulsi M. Is combining or alternating antipyretic therapy more beneficial than monotherapy for febrile children?. British Medical Journal 2010;340(7737):92-3.
15. Pashapour N, Macooei AA, Golmohammadlou S. Alternating ibuprofen and acetaminophen in the treatment of febrile hospitalized children aged 9-24 months. Iranian Journal of Pediatrics June 2009;19(2):164-8.
16. Pereira GL, Dagostini JMC, da Silva Dal Pizzol T. Alternating antipyretics in the treatment of fever in children: a systematic review of randomized clinical trials [Uso alternado de antipiréticos para tratamento da febre em crianças: revisão sistemática de ensaios clínicos randomizados]. Jornal de Pediatria 2012;88(4):289-96.
17. Purssell E. Systematic review of studies comparing combined treatment with paracetamol and ibuprofen, with either drug alone. Archives Of Disease In Childhood 2011;96:1175-9.
18. Ruiz Lazaro PJ. Ibuprofen, alone or combined with paracetamol, is more effective than paracetamol alone in home treatment of fever in children from 6 months to 6 years of age [Administrar ibuprofeno, solo o combinado con paracetamol, es mas efectivo que utilizar solo paracetamol en el tratamiento domiciliario de la fiebre en ninos de 6 meses a 6 anos de edad]. FMC Formacion Medica Continuada En Atencion Primaria 2009;16(5):311.
19. Uhl D. Ibuprofen and/or paracetamol for the treatment of fever in children? [Ibuprofen und paracetamol im wechsel geben?]. Deutsche Apotheker Zeitung 2008;148(44):52-5.
20. Beasley R, Clayton T, Crane J, von Mutius E, Lai CKW, Montefort S, et al.Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme. Lancet 2008;372:1039-48.
21. Brewer EJ. A comparative evaluation of indomethacin, acetaminophen and placebo as antipyretic agents in children. Arthritis and Rheumatism 1968;11(5):645-51.
22. Brown DR, Wilson JT, Kearns GL, Eichler VF, Johnson VA, Bertrand KM. Single-dose pharmacokinetics of ibuprofen and acetaminophen in febrile children. Journal of Clinical Pharmacology 1992;32:231-41.
23. Position Paper DT98-01 of the Drug Therapy and Hazardous Substances Committee. Paediatric Child Health 1998; Vol. 3, issue 4:273-4.
24. Chiappini E, Principi N, Longhi R, Tovo PA, Beccheruci P, et al.Management of fever in children: summary of the Italian Pediatric Society guidelines. Clinical Therapeutics 2009;8:1826-43.
25. Cohet C, Cheng S, MacDonald C, Baker M, Foliaki S, Huntington N, et al.Infections, medication use, and the prevalence of symptoms of asthma, rhinitis, and eczema in childhood. Journal of Epidemiology and Community Health 2004;58:852-7.
26. Crocetti M, Moghbeli N, Serwint J. Fever phobia revisited: have parental misconceptions about fever changed in 20 years?. Pediatrics 2001;107(6):1241-6.
27. Del-Rio-Navarro BE, Ito-Tsuchiya FM, Berber A, Zepeda-Ortega B, Sienra-Monge JJ, Garcia-Almaraz R, et al.Study of the relationship between acetaminophen and asthma in Mexican children aged 6 to 7 years in 3 Mexican cities using ISAAC methodology. Journal of Investigational Allergology and Clinical Immunology 2008;18(3):194.
28. Drwal-Klein LA, Phelps SJ. Antipyretic therapy in the febrile child. Clinical Pharmacology 1992;11:1005-21.
29. Etminan M, Sadatsafavi M, Jafari S, Doyle-Waters M, Aminzadeh K, Fitzgerald JM. Acetaminophen use and the risk of asthma in children and adults: A systematic review and metaanalysis. Chest November 2009;136(5):1316-23.
30. Feldberg W, Gupta KP. Pyrogen fever and prostaglandin like activity in cerebrospinal fluid. Journal of Physiology 1973;228:41-8.
31. Brozek J, Oxman A, Schünemann H. GRADEpro. Version 3.2 for Windows. 2008.
32. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, et al.GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. British Medical Journal 2008;336:924-6.
33. Heubi JE, Barbacci MB, Zimmerman HJ. Therapeutic misadventures with acetaminophen: Hepatotoxicity after multiple doses in children. Journal of Pediatrics 1998;132:22-7.
34. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Statistics in Medicine 2002;21(11):1539-58.
35. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. Available from www.cochrane-handbook.org. The Cochrane Collaboration 2011.
36. Kanabar D, Dale S, Rawat M. A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. Clinical Therapeutics 2007;29:2716-23.
37. Kauffman RE, Sawyer LA, Scheinbaum ML. Antipyretic efficacy of ibuprofen vs acetaminophen. American Journal of Diseases of Children 1992;146:622-5.
38. Kelley MT, Walson PD, Edge JH, Cox S, Mortensen ME. Pharmacokinetics and pharmacodynamics of ibuprofen isomers and acetaminophen in febrile children. Clinical Pharmacology & Therapeutics 1992;52:181-9.
39. Kluger MJ. Drugs for childhood fever (Letter). Lancet 1992;339:70.
40. Kwiatkowski D. The biology of malarial fever. Baillieres Clinical Infectious Diseases 1995;2(2):371-88.
41. Lesko SM, Mitchell AA. The safety of acetaminophen and ibuprofen among children younger than two years old. Pediatrics 1999;104:39.
42. Lesko SM, Louik C, Vezina RM, Mitchell AA. Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics 2002;109:20.
43. Li SF, Lacher F, Crain EF. Acetaminophen and ibuprofen dosing by parents. Pediatric Emergency Care 2000;16:394-7.
44. Lowe AJ, Carlin JB, Bennett CM, Allen KJ, Robertson CF, Axelrad C, et al.Paracetamol use in early life and asthma: prospective birth cohort study. BMJ September 2010;341:c4616.
45. L'Italien C, Jacqz-Aigrain E. Risks and benefits of nonsteroidal anti-inflammatory drugs in children: a comparison with paracetamol. Paediatric Drugs 2001;3:817-58.
46. Mackowiak PA, Plaisance KI. Benefits and risk of antipyretic therapy. Annals New York Academy of Sciences 1998;856:214-23.
47. McIntyre J, Hull D. Comparing efficacy and tolerability of ibuprofen and paracetamol in fever. Archives of Disease in Childhood 1996;74:164-7.
48. Nabulsi M. Is combining or alternating antipyretic therapy more beneficial than monotherapy for febrile children?. British Medical Journal 2009;339:92-4.
49. Newson RB, Shaheen SO, Chinn S, Burney PG. Paracetamol sales and atopic disease in children and adults: An ecological analysis. European Respiratory Journal 2000;16:817-23.
50. Feverish illness in children: Assessment and initial management in children younger than 5 years. National Institue for Health and Clinical Excellence May 2013.
51. Perrott DA, Piira T, Goodenough B, Champion GD. Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever. A meta-analysis. Archives of Pediatrics & Adolescent Medicine 2004;158:521-6.
52. Renn E. The antipyretic use of acetaminophen versus ibuprofen in a pediatric care setting. Physical Therapy 2000;25:395-7.
53. The Cochrane Collaboration. Review Manager (RevMan). 5.0. Copenhagen: The Cochrane Collaboration, 2008.
54. Schmitt BC. Fever phobia: Misconceptions of parents about fevers. American Journal of Diseases of Children 1980;134(2):176-81.
55. Schnaiderman D, Lahat E, Sheefer T, Aladjem M. Antipyretic effectiveness of acetaminophen in febrile seizures: Ongoing prophylaxis versus sporadic usage. European Journal of Paediatrics 1993;152:747-9.
56. Sullivan JE, Farrar HC. Fever and antipyretic use in children. Pediatrics 2011;127(3):580-7.
57. van Stuijvenberg M, Derksen-Lubsen G, Steyerberg EW, Habbema JDF, Moll HA. Randomized controlled trial of ibuprofen syrup administered during febrile illness to prevent febrile seizure recurrences. Pediatrics 1998;102:1-7.
58. Walson PD, Galletta G, Braden NJ, Alexander L. Ibuprofen, acetaminophen, and placebo treatment of febrile children. Clinical Pharmacology & Therapeutics 1989;46:9-17.
59. Widal MF, Abrami P, Lenmoyez J. Anaphylaxis and Idiosyncrasy [Anaphylaxie et idiosyncrasie]. La Presse Medicale 1922;30:189-92.
60. Wilson JT, Brown D, Kearns GL, Eichler VF, Johnson VA, Bertrand KM, et al.Single-dose, placebo-controlled comparative study of ibuprofen and acetaminophen antipyresis in children. Journal of Pediatrics 1991;119:803-11.