Contribution of a heparin-binding haemagglutinin interferon-gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV-infected patients: Comparison with the tuberculin skin test and the QuantiFERON®-TB Gold In-tube

BMC Infectious Diseases

Volumn 15, Issue 1, 2015, Pages

  Wyndham Thomas, Chloé ^a,b   Dirix, Violette ^a   Schepers, Kinda ^b   Martin, Charlotte ^c   Hildebrand, Marc ^d   Goffard, Jean Christophe ^b   Domont, Fanny ^a   Libin, Myriam ^a   Loyens, Marc ^e,f,g   Locht, Camille ^e,f,g   Van Vooren, Jean Paul ^b   Mascart, Françoise ^a,b  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c SAINT PIERRE UNIVERSITY HOSPITAL   (Belgium)

^d IRIS   (Belgium)

^e INSERM U1019   (France)

^f UNIV LILLE   (France)

^g INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Active tuberculosis; Heparin binding haemagglutinin; Human; Human immunodeficiency virus; Interferon gamma release assay; Latent tuberculosis; Multiplex; Mycobacterium tuberculosis; QuantiFERON TB Gold In Tube; Tuberculin skin test

Indexed keywords

CD40 LIGAND; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; ISONIAZID; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUBERCULIN; TUMOR NECROSIS FACTOR ALPHA; GAMMA INTERFERON; HEPARIN-BINDING HEMAGGLUTININ; LECTIN;

ADULT; AGED; ARTICLE; BACTERIUM DETECTION; BCG VACCINATION; BELGIUM; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOSTIMULATION; INCIDENCE; INTERFERON GAMMA RELEASE ASSAY; LATENT TUBERCULOSIS; LUNG INFILTRATE; MALE; MEDICAL HISTORY; MYCOBACTERIUM TUBERCULOSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROSPECTIVE STUDY; RISK FACTOR; SEROCONVERSION; SUPERNATANT; THORAX RADIOGRAPHY; TUBERCULIN TEST; TUBERCULOSIS; VIRUS LOAD; VIRUS REACTIVATION; COMPARATIVE STUDY; COMPLICATION; EVALUATION STUDY; GENETICS; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MIDDLE AGED; MULTIPLEX POLYMERASE CHAIN REACTION; PROCEDURES; YOUNG ADULT;

ADULT; AGED; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; INCIDENCE; INTERFERON-GAMMA; INTERFERON-GAMMA RELEASE TESTS; LATENT TUBERCULOSIS; LECTINS; MALE; MIDDLE AGED; MULTIPLEX POLYMERASE CHAIN REACTION; MYCOBACTERIUM TUBERCULOSIS; TUBERCULIN TEST; YOUNG ADULT;

EID: 84928668098     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/s12879-015-0796-0     Document Type: Article

References (36)

1. Kwan CK, Ernst JD. HIV and tuberculosis: a deadly human syndemic. Clin Microbiol Rev. 2011;24:351-76.
2. WHO | TB/HIV facts 2012-2013 [ http://www.who.int/hiv/topics/tb/tbhiv_facts_2013/en/index.html ]
3. Horsburgh Jr CR. Priorities for the treatment of latent tuberculosis infection in the United States. N Engl J Med. 2004;350:2060-7.
4. WHO global tuberculosis control report 2012 [ http://apps.who.int/iris/bitstream/10665/91355/1/9789241564656_eng.pdf ]
5. Mazurek GH, Jereb J, Vernon A, LoBue P, Goldberg S, Castro K. IGRA expert committee, centers for disease control and prevention (CDC): updated guidelines for using interferon gamma release assays to detect mycobacterium tuberculosis infection - united states, 2010. MMWR Recomm Rep Morb Mortal Wkly Rep Recomm Rep Cent Dis Control. 2010;59:1-25.
6. ECDC 2011: use of interferon-gamma release assays in support of TB diagnosis. [ http://www.ecdc.europa.eu/en/publications/Publications/1103_GUI_IGRA.pdf ]
7. Markowitz N, Hansen NI, Wilcosky TC, Hopewell PC, Glassroth J, Kvale PA, et al. Tuberculin and anergy testing in HIV-seropositive and HIV-seronegative persons. Pulmonary Complications of HIV Infection Study Group. Ann Intern Med. 1993;119:185-93.
8. Huebner RE, Schein MF, Bass Jr JB. The tuberculin skin test. Clin Infect Dis Off Publ Infect Dis Soc Am. 1993;17:968-75.
9. Santin M, Muñoz L, Rigau D. Interferon-γ release assays for the diagnosis of tuberculosis and tuberculosis infection in HIV-infected adults: a systematic review and meta-analysis. PLoS One. 2012;7:e32482.
10. Cattamanchi A, Smith R, Steingart KR, Metcalfe JZ, Date A, Coleman C, et al. Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis. J Acquir Immune Defic Syndr. 1999;56:230-8.
11. Redelman-Sidi G, Sepkowitz KA. Interferon gamma release assays in the diagnosis of latent tuberculosis infection among immunocompromised adults. Am J Respir Crit Care Med. 2013;188:422-31.
12. Locht C, Hougardy J-M, Rouanet C, Place S, Mascart F. Heparin-binding hemagglutinin, from an extrapulmonary dissemination factor to a powerful diagnostic and protective antigen against tuberculosis. Tuberc Edinb Scotl. 2006;86:303-9.
13. Hougardy J-M, Schepers K, Place S, Drowart A, Lechevin V, Verscheure V, et al. Heparin-binding-hemagglutinin-induced IFN-gamma release as a diagnostic tool for latent tuberculosis. PLoS One. 2007;2:e926.
14. Dessein R, Corbière V, Nortier J, Dratwa M, Gastaldello K, Pozdzik A, et al. Heparin-binding haemagglutinin, a New tool for the detection of latent mycobacterium tuberculosis infection in hemodialysis patients. PLoS One. 2013;8:e71088.
15. Loxton AG, Black GF, Stanley K, Walzl G. Heparin-binding hemagglutinin induces IFN-γ+IL-2+ IL-17+ multifunctional CD4+ T cells during latent but Not active tuberculosis disease. Clin Vaccine Immunol CVI. 2012;19:746-51.
16. Registre belge de la tuberculose 2012 [ http://www.fares.be/documents/Regtbc2012.pdf ].
17. TB-IRIS Case Definition - MED - International Network Study of HIV-Associated IRIS, University of Minnesota [ http://www.inshi.umn.edu/definitions/TB_IRIS/home.html ]
18. Recommandations concernant le dépistage ciblé et le traitement de l'infection tuberculeuse latente [ http://www.fares.be/documents/recomm.pdf ]
19. Van Zyl-Smit RN, Zwerling A, Dheda K, Pai M. Within-subject variability of interferon-g assay results for tuberculosis and boosting effect of tuberculin skin testing: a systematic review. PLoS One. 2009;4:e8517.
20. Wyndham-Thomas C, Corbière V, Dirix V, Smits K, Domont F, Libin M, et al.: A short incubation Heparin-Binding Haemagglutinin interferon-gamma release assay for the detection of latent tuberculosis: the key role of effector memory CD4+ T lymphocytes. Clin Vaccine Immunol CVI 2014.
21. Masungi C, Temmerman S, Van Vooren J-P, Drowart A, Pethe K, Menozzi FD, et al. Differential T and B cell responses against Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin in infected healthy individuals and patients with tuberculosis. J Infect Dis. 2002;185:513-20.
22. Temmerman ST, Place S, Debrie A-S, Locht C, Mascart F. Effector functions of heparin-binding hemagglutinin-specific CD8+ T lymphocytes in latent human tuberculosis. J Infect Dis. 2005;192:226-32.
23. WHO | Tuberculosis country profiles [ http://www.who.int/tb/country/data/profiles/en/ ]
24. Agresti A. Categorical Data Analysis. 2nd ed. United States of America: John Wiley & Sons; 2002.
25. Getahun H, Granich R, Sculier D, Gunneberg C, Blanc L, Nunn P, et al. Implementation of isoniazid preventive therapy for people living with HIV worldwide: barriers and solutions. AIDS Lond Engl. 2010;24 Suppl 5:S57-65.
26. Lester R, Hamilton R, Charalambous S, Dwadwa T, Chandler C, Churchyard GJ, et al. Barriers to implementation of isoniazid preventive therapy in HIV clinics: a qualitative study. AIDS Lond Engl. 2010;24 Suppl 5:S45-8.
27. Smith SG, Lecher S, Blitz R, Locht C, Dockrell HM. Broad heparin-binding haemagglutinin-specific cytokine and chemokine response in infants following Mycobacterium bovis BCG vaccination. Eur J Immunol. 2010;42:2511-22.
28. Delogu G, Chiacchio T, Vanini V, Butera O, Cuzzi G, Bua A, et al. Methylated HBHA produced in M smegmatis discriminates between active and non-active tuberculosis disease among RD1-responders. PloS One. 2011;6:e18315.
29. Young DB, Gideon HP, Wilkinson RJ. Eliminating latent tuberculosis. Trends Microbiol. 2009;17:183-8.
30. O'Garra A, Redford PS, McNab FW, Bloom CI, Wilkinson RJ, Berry MPR. The immune response in tuberculosis. Annu Rev Immunol. 2013;31:475-527.
31. Corbière V, Pottier G, Bonkain F, Schepers K, Verscheure V, Lecher S, et al. Risk stratification of latent tuberculosis defined by combined interferon gamma release assays. PLoS One. 2012;7:e43285.
32. Place S, Verscheure V, de San N, Hougardy J-M, Schepers K, Dirix V, et al. Heparin-binding, hemagglutinin-specific IFN-gamma synthesis at the site of infection during active tuberculosis in humans. Am J Respir Crit Care Med. 2010;182:848-54.
33. Hougardy J-M, Place S, Hildebrand M, Drowart A, Debrie A-S, Locht C, et al. Regulatory T cells depress immune responses to protective antigens in active tuberculosis. Am J Respir Crit Care Med. 2007;176:409-16.
34. Chevalier MF, Weiss L. The split personality of regulatory T cells in HIV infection. Blood. 2013;121:29-37.
35. Choe EY, Schoenberger ES, Groopman JE, Park I-W. HIV Nef inhibits T cell migration. J Biol Chem. 2002;277:46079-84.
36. Oni T, Burke R, Tsekela R, Bangani N, Seldon R, Gideon HP, et al. High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB screening. Thorax. 2011;66:669-73.