Comparison between frailty index of deficit accumulation and phenotypic model to predict risk of falls: Data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) Hamilton cohort

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Li, Guowei ^a   Thabane, Lehana ^a,b   Ioannidis, George ^a   Kennedy, Courtney ^a   Papaioannou, Alexandra ^a   Adachi, Jonathan D ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b ST JOSEPH S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; COHORT ANALYSIS; COMPARATIVE STUDY; CORRELATION COEFFICIENT; DEATH; FALLING; FEMALE; FOLLOW UP; FRACTURE; FRAILTY INDEX OF DEFICIT ACCUMULATION; GENETIC MODEL; HUMAN; LONGITUDINAL STUDY; MIDDLE AGED; OSTEOPOROSIS; OUTCOME ASSESSMENT; PHENOTYPIC FRAILTY MODEL; PREDICTION; QUESTIONNAIRE; RATING SCALE; RISK ASSESSMENT; SURVIVAL; VERY ELDERLY; FRAIL ELDERLY; PATHOPHYSIOLOGY; POSTMENOPAUSE OSTEOPOROSIS; PROPORTIONAL HAZARDS MODEL; RISK FACTOR;

ACCIDENTAL FALLS; AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; FRAIL ELDERLY; HUMANS; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; PROPORTIONAL HAZARDS MODELS; RISK FACTORS;

EID: 84928621930     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0120144     Document Type: Article

References (49)

1. World Health Organization. Ageing. [Updated March 2012, Accessed May 2014]. Available: http://www.who.int/topics/ageing/en/.
2. Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K (2013) Frailty in elderly people. Lancet 381:752-762. doi: 10.1016/S0140-6736 (12) 62167-9 PMID: 23395245
3. Gobbens RJ, Luijkx KG, Wijnen-Sponselee MT, Schols JM (2010) Toward a conceptual definition of frail community dwelling older people. Nursing Outlook 58:76-86. doi: 10.1016/j.outlook.2009.09.005 PMID: 20362776
4. Sternberg SA, Wershof Schwartz A, Karunananthan S, Bergman H, Mark Clarfield A (2011) The identification of frailty: a systematic literature review. J Am Geriatr Soc 59:2129-2138. doi: 10.1111/j.1532-5415.2011.03597.x PMID: 22091630
5. Chen X, Mao G, Leng SX (2014) Frailty syndrome: an overview. Clinical interventions in aging 9:433. doi: 10.2147/CIA. S45300 PMID: 24672230
6. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, et al. (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146-156. PMID: 11253156
7. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, et al. (2005) A global clinical measure of fitness and frailty in elderly people. CMAJ 173:489-495. PMID: 16129869
8. Kulminski AM, Ukraintseva SV, Kulminskaya IV, Arbeev KG, Land K, et al. (2008) Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study. J Am Geriatr Soc 56:898-903. doi: 10.1111/j.1532-5415.2008.01656.x PMID: 18363679
9. Rockwood K, Abeysundera MJ, Mitnitski A (2007) How should we grade frailty in nursing home patients? Journal of the American Medical Directors Association 8:595-603. PMID: 17998116
10. Rockwood K, Andrew M, Mitnitski A (2007) A comparison of two approaches to measuring frailty in elderly people. J Gerontol A Biol Sci Med Sci 62:738-743. PMID: 17634321
11. Deandrea S, Lucenteforte E, Bravi F, Foschi R, La Vecchia C, et al. (2010) Risk factors for falls in communitydwelling older people: a systematic review and meta-analysis. Epidemiology 21:658-668. doi: 10.1097/EDE.0b013e3181e89905 PMID: 20585256
12. Rubenstein LZ, Josephson KR (2002) The epidemiology of falls and syncope. Clin Geriatr Med 18:141-158. PMID: 12180240
13. Karlsson MK, Vonschewelov T, Karlsson C, Coster M, Rosengen BE (2013) Prevention of falls in the elderly: A review. Scand J Public Health.
14. Rubenstein LZ (2006) Falls in older people: epidemiology, risk factors and strategies for prevention. Age and ageing 35: ii37-ii41. PMID: 16926202
15. Peel NM (2011) Epidemiology of falls in older age. Canadian journal on aging 30:7-19. doi: 10.1017/S071498081000070X PMID: 21401978
16. Ensrud KE, Ewing SK, Taylor BC, Fink HA, Cawthon PM, et al. (2008) Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med 168:382-389. doi: 10.1001/archinternmed.2007.113 PMID: 18299493
17. Rockwood K, Howlett SE, MacKnight C, Beattie BL, Bergman H, et al. (2004) Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: report from the Canadian study of health and aging. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 59:1310-1317. PMID: 15699531
18. Bandeen-Roche K, Xue Q-L, Ferrucci L, Walston J, Guralnik JM, et al. (2006) Phenotype of frailty: characterization in the women's health and aging studies. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 61:262-266. PMID: 16567375
19. Hooven FH, Adachi JD, Adami S, Boonen S, Compston J, et al. (2009) The Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design. Osteoporos Int 20:1107-1116. doi: 10.1007/s00198-009-0958-2 PMID: 19468663
20. Fugate Woods N, La Croix AZ, Gray SL, Aragaki A, Cochrane BB, et al. (2005) Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. Journal of the American Geriatrics Society 53:1321-1330. PMID: 16078957
21. Tom SE, Adachi JD, Anderson FA Jr, Boonen S, Chapurlat RD, et al. (2013) Frailty and fracture, disability, and falls: a multiple country study from the global longitudinal study of osteoporosis in women. J Am Geriatr Soc 61:327-334. doi: 10.1111/jgs.12146 PMID: 23351064
22. Li G, Ioannidis G, Pickard L, Kennedy C, Papaioannou A, et al. (2014) Frailty index of deficit accumulation and falls: data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) Hamilton cohort. BMC Musculoskeletal Disorders 15:185. doi: 10.1186/1471-2474-15-185 PMID: 24885323
23. Ganz DA, Bao Y, Shekelle PG, Rubenstein LZ (2007) Will my patient fall? JAMA 297:77-86. PMID: 17200478
24. Al-Aama T (2011) Falls in the elderly: spectrum and prevention. Can Fam Physician 57:771-776. PMID: 21753098
25. Siminoski K, Leslie WD, Frame H, Hodsman A, Josse RG, et al. (2005) Recommendations for bone mineral density reporting in Canada. JOURNAL-CANADIAN ASSOCIATION OF RADIOLOGISTS 56:178. PMID: 16144280
26. Unnanuntana A, Gladnick BP, Donnelly E, Lane JM (2010) The assessment of fracture risk. The Journal of Bone & Joint Surgery 92:743-753.
27. FRAX. WHO Fracture Risk Assessment Tool. [Updated March 2012, Accessed May 2014]. Available: http://www.shef.ac.uk/FRAX/.
28. National Osteoporosis Foundation. Clinician's Guide to Prevention and Treatment of Osteoporosis. Washington, DC: National Osteoporosis Foundation; 2014.
29. Harrell FE, Califf RM, Pryor DB, Lee KL, Rosati RA (1982) Evaluating the yield of medical tests. Jama 247:2543-2546. PMID: 7069920
30. Grambsch PM, Therneau TM (1994) Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 81:515-526.
31. Akaike H (1974) A new look at the statistical model identification. Automatic Control, IEEE Transactions on 19:716-723.
32. Graham JW (2009) Missing data analysis: Making it work in the real world. Annual review of psychology 60:549-576. doi: 10.1146/annurev. psych.58.110405.085530 PMID: 18652544
33. Horton NJ, Kleinman KP (2007) Much ado about nothing. The American Statistician 61. PMID: 17401454
34. Forti P, Rietti E, Pisacane N, Olivelli V, Maltoni B, et al. (2012) A comparison of frailty indexes for prediction of adverse health outcomes in an elderly cohort. Archives of gerontology and geriatrics 54:16-20. doi: 10.1016/j.archger.2011.01.007 PMID: 21339007
35. Malmstrom TK, Miller DK, Morley JE (2014) A Comparison of Four Frailty Models. Journal of the American Geriatrics Society 62:721-726. doi: 10.1111/jgs.12735 PMID: 24635726
36. Jung HW, Kim SW, Ahn S, Lim JY, Han JW, et al. (2014) Prevalence and outcomes of frailty in Korean elderly population: comparisons of a multidimensional frailty index with two phenotype models. PLoS One 9:e87958. doi: 10.1371/journal.pone.0087958 PMID: 24505338
37. Dent E, Chapman I, Howell S, Piantadosi C, Visvanathan R (2013) Frailty and functional decline indices predict poor outcomes in hospitalised older people. Age and ageing: aft181. doi: 10.1093/ageing/aft059 PMID: 23739047
38. Woo J, Leung J, Morley JE (2012) Comparison of frailty indicators based on clinical phenotype and the multiple deficit approach in predicting mortality and physical limitation. Journal of the American Geriatrics Society 60:1478-1486. doi: 10.1111/j.1532-5415.2012.04074.x PMID: 22861118
39. Ravindrarajah R, Lee DM, Pye SR, Gielen E, Boonen S, et al. (2013) The ability of three different models of frailty to predict all-cause mortality: results from the European Male Aging Study (EMAS). Archives of gerontology and geriatrics 57:360-368. doi: 10.1016/j.archger.2013.06.010 PMID: 23871598
40. Cesari M, Gambassi G, Van Kan GA, Vellas B (2014) The frailty phenotype and the frailty index: different instruments for different purposes. Age and ageing 43:10-12. doi: 10.1093/ageing/aft160 PMID: 24132852
41. Rockwood K, Mitnitski A (2007) Frailty in relation to the accumulation of deficits. J Gerontol A Biol Sci Med Sci 62:722-727. PMID: 17634318
42. Whitson HE, Purser JL, Cohen HJ (2007) Frailty thy name is... Phrailty? The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 62:728-730. PMID: 17634319
43. Searle SD, Mitnitski A, Gahbauer EA, Gill TM, Rockwood K (2008) A standard procedure for creating a frailty index. BMC Geriatr 8:24. doi: 10.1186/1471-2318-8-24 PMID: 18826625
44. Hundrup YA, Hoidrup S, Obel EB, Rasmussen NK (2004) The validity of self-reported fractures among Danish female nurses: comparison with fractures registered in the Danish National Hospital Register. Scand J Public Health 32:136-143. PMID: 15255503
45. Rahman A, Gibney L, Person SD, Williams OD, Kiefe C, et al. (2005) Validity of self-reports of reasons for hospitalization by young adults and risk factors for discordance with medical records: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Epidemiol 162:491-498. PMID: 16076836
46. Gregson C, Dennison EM, Compston JE, Adami S, Adachi JD, et al. (2014) Disease-specific perception of fracture risk and incident fracture rates: GLOW cohort study. Osteoporosis international 25:85-95. doi: 10.1007/s00198-013-2438-y PMID: 23884437
47. Papaioannou A, Joseph L, Ioannidis G, Berger C, Anastassiades T, et al. (2005) Risk factors associated with incident clinical vertebral and nonvertebral fractures in postmenopausal women: the Canadian Multicentre Osteoporosis Study (CaMos). Osteoporosis international 16:568-578. PMID: 15517191
48. Kreiger N, Tenenhouse A, Joseph L, Mackenzie T, Poliquin S, et al. (1999) Research notes: The Canadian multicentre osteoporosis study (CaMos): Background, rationale, methods. Canadian Journal on Aging/La Revue canadienne du vieillissement 18:376-387.
49. Diez-Perez A, Adachi JD, Adami S, Anderson FA Jr, Boonen S, et al. (2013) Risk factors for treatment failure with antiosteoporosis medication: The global longitudinal study of osteoporosis in women (GLOW). J Bone Miner Res.