Asymmetric dimethyl-arginine metabolism in a murine model of cigarette smoke-mediated lung inflammation

Journal of Immunotoxicology

Volumn 12, Issue 3, 2015, Pages 273-282

  Staab, Elizabeth B ^a   Weigel, Jason ^a   Xiao, Fengxia ^a   Madayiputhiya, Nandakumar ^b   Wyatt, Todd A ^a,c,d   Wells, Sandra M ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Airway; Dimethyl arginine dimethylaminohydrolase; Nuclear factor B

Indexed keywords

ARGININE; CIGARETTE SMOKE; DIMETHYLARGININASE; DIMETHYLARGININASE 1; DIMETHYLARGININASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AMIDASE; N,N-DIMETHYLARGININE; TUMOR NECROSIS FACTOR;

AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; CELL COUNT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LUNG HOMOGENATE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; UPREGULATION; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; CHEMICALLY INDUCED; ENVIRONMENTAL EXPOSURE; EPITHELIUM CELL; GENETICS; HUMAN; IMMUNOLOGY; LUNG; METABOLISM; PATHOLOGY; SMOKING; TRANSGENIC MOUSE;

MURINAE; MUS; MUS MUSCULUS;

AMIDOHYDROLASES; ANIMALS; ARGININE; CELL LINE; ENVIRONMENTAL EXPOSURE; EPITHELIAL CELLS; HUMANS; LUNG; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NITRIC OXIDE SYNTHASE; PNEUMONIA; SMOKING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84928616747     PISSN: 1547691X     EISSN: 15476901     Source Type: Journal    
DOI: 10.3109/1547691X.2014.961619     Document Type: Article

References (51)

1. Ahmad, T., Mabalirajan, U., Ghosh, B., and Agrawal, A. 2010. Altered asymmetric dimethyl-arginine metabolism in allergically inflamed mouse lungs. Am. J. Respir. Cell Mol. Biol. 42:3-8.
2. Angelis, N., Porpodis, K., Zarogoulidis, P., et al. 2014. Airway inflammation in chronic obstructive pulmonary disease. J. Thoracic Dis. 6:S167-172.
3. Baylis, C. 2006. Arginine, arginine analogs, and nitric oxide production in chronic kidney disease. Nat. Clin. Pract. Nephrol. 2:209-220.
4. Boger, R. H., Bode-Boger, S. M., Tsao, P. S., et al. 2000. An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes. J. Am. Coll. Cardiol. 36:2287-2295.
5. Bracke, K. R., Dentener, M. A., Papakonstantinou, E., et al. 2010. Enhanced deposition of low-molecular-weight hyaluronan in lungs of cigarette smoke-exposed mice. Am. J. Respir. Cell Mol. Biol. 42: 753-761.
6. Bulau, P., Zakrzewicz, D., Kitowska, K., et al. 2007. Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA. Am. J. Physiol. 292:L18-24.
7. Churg, A., Dai, J., Tai, H., et al. 2002. Tumor necrosis factor-a is central to acute cigarette smoke-induced inflammation and connective tissue breakdown. Am. J. Respir. Crit. Care Med. 166:849-854.
8. Churg, A., Wang, R. D., Tai, H., et al. 2003. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via TNFa release. Am. J. Respir. Crit. Care Med. 167:1083-1089.
9. Closs, E. I., Basha, F. Z., Habermeier, A., and Forstermann, U. 1997. Interference of L-arginine analogues with L-arginine transport mediated by the y+ carrier hCAT-2B. Nitric Oxide Biol. Chem. 1:65-73.
10. Dayoub, H., Achan, V., Adimoolam, S., et al. 2003. Dimethyl-arginine dimethylaminohydrolase regulates NO synthesis: Genetic and physiological evidence. Circulation 108:3042-3047.
11. Di Stefano, A., Caramori, G., Oates, T., et al. 2002. Increased expression of NF-κB in bronchial biopsies from smokers and patients with COPD. Eur. Resp. J. 20:556-563.
12. Eid, H. M., Arnesen, H., Hjerkinn, E. M., et al. 2004. Relationship between obesity, smoking, and the endogenous nitric oxide synthase inhibitor, asymmetric dimethyl-arginine. Metab. Clin. Exp. 53: 1574-1579.
13. Elliott, M. K., Sisson, J. H., West, W. W., and Wyatt, T. A. 2006. Differential in vivo effects of whole cigarette smoke exposure versus cigarette smoke extract on mouse ciliated tracheal epithelium. Exp. Lung Res. 32:99-118.
14. Elliott, M. K., Sisson, J. H., and Wyatt, T. A. 2007. Effects of cigarette smoke and alcohol on ciliated tracheal epithelium and inflammatory cell recruitment. Am. J. Respir. Cell Mol. Biol. 36:452-459.
15. Forbes, S. P., Druhan, L. J., Guzman, J. E., et al. 2008. Mechanism of 4-HNE mediated inhibition of hDDAH-1: Implications in no regulation. Biochemistry 47:1819-1826.
16. Gentry-Nielsen, M. J., Vander Top, E., Snitily, M. U., et al. 2004. A rat model to determine the biomedical consequences of concurrent ethanol ingestion and cigarette smoke exposure. Alcoholism: Clin. Exp. Med. 28:1120-1128.
17. Hu, X., Atzler, D., Xu, X., et al. 2011. Dimethyl-arginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethyl-arginine. Arterio-sclerosis Thrombosis Vasc. Biol. 31:1540-1546.
18. Ichinose, M., Sugiura, H., Yamagata, S., et al. 2000. Increase in reactive nitrogen species production in chronic obstructive pulmonary disease airways. Am. J. Respir. Crit. Care Med. 162:701-706.
19. Imamura, M., Waseda, Y., Marinova, G.V., et al. 2007. Alterations of NOS, arginase, and DDAH protein expression in rabbit cavernous tissue after administration of cigarette smoke extract. Am. J. Physiol. 293:R2081-2089.
20. Klein, E., Weigel, J., Buford, M. C., et al. 2010. Asymmetric dimethylarginine potentiates lung inflammation in a mouse model of allergic asthma. Am. J. Physiol. 299:L816-825.
21. Kou, Y. R., Kwong, K., and Lee, L. Y. 2011. Airway inflammation and hypersensitivity induced by chronic smoking. Resp. Physiol. Neurobiol. 178:395-405.
22. Loukili, N., Rosenblatt-Velin, N., Rolli, J., et al. 2010. Oxidants positively or negatively regulate nuclear factor-κB in a context-dependent manner. J. Biol. Chem. 285:15746-15752.
23. Lu, T. M., Ding, Y. A., Leu, H. B., et al. 2004. Effect of rosuvastatin on plasma levels of asymmetric dimethyl-arginine in patients with hypercholes-terolemia. Am. J. Cardiol. 94:157-161.
24. MacNee, W. 2005. Pulmonary and systemic oxidant/anti-oxidant imbalance in chronic obstructive pulmonary disease. Proc. Am. Thor. Soc. 2:50-60.
25. Martins-Green, M., Adhami, N., Frankos, M., et al. 2014. Cigarette smoke toxins deposited on surfaces: Implications for human health. PLoS ONE. 9:e86391.
26. Matthews, J., Botting, C., Panico, M., et al. 1996. Inhibition of NF-κB binding by nitric oxide. Nucl. Acids Res. 24:2236-2242.
27. Nyunoya, T., Mebratu, Y., Contreras, A., et al. 2014. Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung. Am. J. Respir. Cell Mol. Biol. 50:471-482.
28. Ogawa, T., Kimoto, M., and Sasaoka, K. 1989. Purification and properties of a new enzyme, NG, NG-dimethyl-arginine dimethylaminohydrolase, from rat kidney. J. Biol. Chem. 264:10205-10209.
29. Osoata, G. O., Hanazawa, T., Brindicci, C., et al. 2009. Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition by fudosteine. Chest 135:1513-1520.
30. Pacher, P., Beckman, J. S., and Liaudet, L. 2007. Nitric oxide and peroxynitrite in health and disease. Physiol. Rev. 87:315-424.
31. Paik, W. K., and Kim, S. 1968. Protein methylase I. Purification and properties of the enzyme. J. Biol. Chem. 243:2108-2114.
32. Pope, A. J., Karrupiah, K., Kearns, P. N., et al. 2009. Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production. J. Biol. Chem. 284:35338-35347.
33. Rahman, I., and MacNee, W. 1998. Role of transcription factors in inflammatory lung diseases. Thorax 53:601-612.
34. Raptis, V., Georgianos, P. I., Sarafdis, P. A., et al. 2014. Elevated asymmetric dimethyl-arginine is associated with oxidant stress aggravation in patients with early stage autosomal dominant polycystic kidney disease. Kidney Blood Pressure Res. 38:72-82.
35. Rodionov, R. N., Murray, D. J., Vaulman, S. F., et al. 2010. Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production. J. Biol. Chem. 285:5385-5391.
36. Scott, J. A., North, M. L., Rafii, M., et al. 2011. Asymmetric dimethylarginine is increased in asthma. Am. J. Respir. Crit. Care Med. 184: 779-785.
37. Shen, L. L., Liu, Y. N., Shen, H. J., et al. 2014. Inhalation of glycopyrronium inhibits cigarette smoke-induced acute lung inflammation in a murine model of COPD. Int. Immunopharmacol. 18: 358-364.
38. Sobczak, A., Goniewicz, M. L., and Szoltysek-Boldys, I. 2009. ADMA and SDMA levels in healthy men exposed to tobacco smoke. Atherosclerosis 205:357-359.
39. Sousse, L. E., Yamamoto, Y., Enkhbaatar, P., et al. 2011. Acute lung injury-induced collagen deposition is associated with elevated asymmetric dimethyl-arginine and arginase activity. Shock 35:282-288.
40. Tamimi, A., Serdarevic, D., and Hanania, N. A. 2012. The effects of cigarette smoke on airway inflammation in asthma and COPD: Therapeutic implications. Resp. Med. 106:319-328.
41. Vallance, P., and Leiper, J. 2004. Cardiovascular biology of the asymmetric dimethyl-arginine: Dimethyl-arginine dimethylaminohydrolase pathway. Arteriosclerosis Thrombosis Vasc. Biol. 24: 1023-1030.
42. Vladimirova-Kitova, L. G., and Deneva-Koycheva, T. I. 2012. The effect of simvastatin on asymmetric dimethyl-arginine and flow-mediated vasodilation after optimizing the LDL level: A randomized, placebocontrolled study. Vasc. Pharmacol. 56:122-130.
43. Wang, J., Sim, A. S., Wang, X. L., et al. 2006. Relations between plasma asymmetric dimethyl-arginine (ADMA) and risk factors for coronary disease. Atherosclerosis 184:383-388.
44. Welch, W. J., and Wilcox, C. S. 1997. Macula densa arginine delivery and uptake in the rat regulates glomerular capillary pressure. Effects of salt intake. J. Clin. Invest. 100:2235-2242.
45. Wells, S., Buford, M., and Holian, A. 2007. Asymmetric dimethylarginine (ADMA) exacerbates airway hyper-responsiveness and inflammation in murine models of asthma. Am. J. Respir. Crit. Care Med. 175:A204.
46. Wells, S., Klein, E., Weigel, J., and Wyatt, T. 2011. Asymmetric dimethyl-arginine (ADMA) potentiates cigarette smoke-induced pulmonary inflammation in mice. Am. J. Respir. Crit. Care Med. 183: A3257.
47. Wells, S. M., and Holian, A. 2007. Asymmetric dimethyl-arginine induces oxidative and nitrosative stress in murine lung epithelial cells. Am. J. Respir. Cell Mol. Biol. 36:520-528.
48. Wells, S. M., Buford, M. C., Migliaccio, C. T., and Holian, A. 2009. Elevated asymmetric dimethyl-arginine alters lung function and induces collagen deposition in mice. Am. J. Respir. Cell Mol. Biol. 40:179-188.
49. Wyatt, T. A., Schmidt, S. C., Rennard, S. I., et al. 2000. Acetaldehydestimulated PKC activity in airway epithelial cells treated with smoke extract from normal and smokeless cigarettes. Proc. Soc. Exp. Biol. Med. 225:91-97.
50. Zakrzewicz, D., and Eickelberg, O. 2009. From arginine methylation to ADMA: A novel mechanism with therapeutic potential in chronic lung diseases. BMC Pulm. Med. 9:5.
51. Zhang, W. Z., Venardos, K., Chin-Dusting, J., and Kaye, D. M. 2006. Adverse effects of cigarette smoke on NO bioavailability: Role of arginine metabolism and oxidative stress. Hypertension 48: 278-285.