Oxytocin reduces caloric intake in men

Obesity

Volumn 23, Issue 5, 2015, Pages 950-956

  Lawson, Elizabeth A ^a   Marengi, Dean A ^a   Desanti, Rebecca L ^a   Holmes, Tara M ^a   Schoenfeld, David A ^b   Tolley, Christiane J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ; GHRELIN; GLUCOSE; INSULIN; LEPTIN; OXYTOCIN; PEPTIDE YY; PLACEBO; TRIACYLGLYCEROL; ANOREXIGENIC AGENT; GLUCOSE BLOOD LEVEL;

ABDOMINAL PAIN; ADULT; ANXIETY DISORDER; ARTICLE; BODY MASS; BODY WEIGHT; CALORIC INTAKE; CALORIMETRY; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CROSSOVER PROCEDURE; DECREASED APPETITE; DIZZINESS; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG BLOOD LEVEL; DRUG SAFETY; DRY THROAT; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HEADACHE; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; REGULATORY MECHANISM; RESTING ENERGY EXPENDITURE; RHINORRHEA; SINGLE DRUG DOSE; TRIACYLGLYCEROL BLOOD LEVEL; VISUAL ANALOG SCALE; ADOLESCENT; APPETITE; BLOOD; DRUG EFFECTS; ENERGY METABOLISM; INDIRECT CALORIMETRY; INTRANASAL DRUG ADMINISTRATION; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADMINISTRATION, INTRANASAL; ADOLESCENT; ADULT; APPETITE; APPETITE DEPRESSANTS; BLOOD GLUCOSE; CALORIMETRY, INDIRECT; CHOLECYSTOKININ; CROSS-OVER STUDIES; ENERGY INTAKE; ENERGY METABOLISM; HUMANS; INSULIN; MALE; MIDDLE AGED; OXYTOCIN; YOUNG ADULT;

EID: 84928583199     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.21069     Document Type: Article

References (40)

1. Ogden CL, Carroll MD, Kit BK, Flegal KM,. Prevalence of obesity in the United States, 2009-2010. NCHS Data Brief 2012; 1-8.
2. Gloy VL, Briel M, Bhatt DL, et al. Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials. BMJ 2013; 347: f5934.
3. Yanovski SZ, Yanovski JA,. Long-term drug treatment for obesity: a systematic and clinical review. JAMA 2014; 311: 74-86.
4. Arletti R, Benelli A, Bertolini A,. Influence of oxytocin on feeding behavior in the rat. Peptides 1989; 10: 89-93.
5. Olson BR, Drutarosky MD, Chow MS, Hruby VJ, Stricker EM, Verbalis JG,. Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats. Peptides 1991; 12: 113-118.
6. Kasahara Y, Takayanagi Y, Kawada T, Itoi K, Nishimori K,. Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure. Biosci Biotechnol Biochem 2007; 71: 3122-3126.
7. Deblon N, Veyrat-Durebex C, Bourgoin L, et al. Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PloS One 2011; 6: e25565.
8. Noble EE, Billington CJ, Kotz CM, Wang C,. Oxytocin in the ventromedial hypothalamic nucleus reduces feeding and acutely increases energy expenditure. Am J Physiol Regul Integr Comp Physiol 2014; 307: R737-R745.
9. Zhang G, Bai H, Zhang H, et al. Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron 2011; 69: 523-535.
10. Zhang G, Cai D,. Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment. Am J Physiol Endocrinol Metab 2011; 301: E1004-E1012.
11. Blevins JE, Graham JL, Morton GJ, et al. Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. Am J Physiol Regu Integr Comp Physiol 2014. ajpregu 00441 02014.
12. Zhang H, Wu C, Chen Q, et al. Treatment of obesity and diabetes using oxytocin or analogs in patients and mouse models. PloS One 2013; 8: e61477.
13. Borg J, Simren M, Ohlsson B,. Oxytocin reduces satiety scores without affecting the volume of nutrient intake or gastric emptying rate in healthy subjects. Neurogastroenterol Motil 2011; 23: 56-61, e55.
14. Ott V, Finlayson G, Lehnert H, et al. Oxytocin reduces reward-driven food intake in humans. Diabetes 2013; 62: 3418-3425.
15. MacDonald E, Dadds MR, Brennan JL, Williams K, Levy F, Cauchi AJ,. A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research. Psychoneuroendocrinology 2011; 36: 1114-1126.
16. Gagnon DD, Rintamaki H, Gagnon SS, et al. Cold exposure enhances fat utilization but not non-esterified fatty acids, glycerol or catecholamines availability during submaximal walking and running. Front Physiol 2013; 4: 99.
17. Flint A, Raben A, Blundell JE, Astrup A,. Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 2000; 24: 38-48.
18. Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR,. Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice. Mol Endocrinol 2008; 22: 1723-1734.
19. Striepens N, Kendrick KM, Hanking V, et al. Elevated cerebrospinal fluid and blood concentrations of oxytocin following its intranasal administration in humans. Scientific Rep 2013; 3: 3440.
20. Atasoy D, Betley JN, Su HH, Sternson SM,. Deconstruction of a neural circuit for hunger. Nature 2012; 488: 172-177.
21. Blevins JE, Schwartz MW, Baskin DG,. Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size. Am J Physiol Regul Integr Comp Physiol 2004; 287: R87-R96.
22. Sabatier N, Caquineau C, Dayanithi G, et al. Alpha-melanocyte-stimulating hormone stimulates oxytocin release from the dendrites of hypothalamic neurons while inhibiting oxytocin release from their terminals in the neurohypophysis. J Neurosci 2003; 23: 10351-10358.
23. Rinaman L,. Oxytocinergic inputs to the nucleus of the solitary tract and dorsal motor nucleus of the vagus in neonatal rats. J Comp Neurol 1998; 399: 101-109.
24. McCann MJ, Rogers RC,. Oxytocin excites gastric-related neurones in rat dorsal vagal complex. J Physiol 1990; 428: 95-108.
25. Sabatier N, Leng G, Menzies J,. Oxytocin, feeding, and satiety. Front Endocrinol 2013; 4: 35.
26. Sofroniew MV,. Projections from vasopressin, oxytocin, and neurophysin neurons to neural targets in the rat and human. J Histochem Cytochem 1980; 28: 475-478.
27. Qi J, Yang JY, Song M, Li Y, Wang F, Wu CF,. Inhibition by oxytocin of methamphetamine-induced hyperactivity related to dopamine turnover in the mesolimbic region in mice. Naunyn-Schmiedeberg's Arch Pharmacol 2008; 376: 441-448.
28. Mullis K, Kay K, Williams DL,. Oxytocin action in the ventral tegmental area affects sucrose intake. Brain Res 2013; 1513: 85-91.
29. Wu CL, Hung CR, Chang FY, Pau KY, Wang PS,. Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats. Naunyn-Schmiedeberg's Arch Pharmacol 2003; 367: 406-413.
30. Wu CL, Doong ML, Wang PS,. Involvement of cholecystokinin receptor in the inhibition of gastrointestinal motility by oxytocin in ovariectomized rats. Eur J Pharmacol 2008; 580: 407-415.
31. Vila G, Riedl M, Resl M, et al. Systemic administration of oxytocin reduces basal and lipopolysaccharide-induced ghrelin levels in healthy men. J Endocrinol 2009; 203: 175-179.
32. Takayanagi Y, Kasahara Y, Onaka T, Takahashi N, Kawada T, Nishimori K,. Oxytocin receptor-deficient mice developed late-onset obesity. Neuroreport 2008; 19: 951-955.
33. Morton GJ, Thatcher BS, Reidelberger RD, et al. Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats. Am J Physiol Endocrinol Metab 2012; 302: E134-E144.
34. Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U, Yada T,. Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging 2011; 3: 1169-1177.
35. Gould BR, Zingg HH,. Mapping oxytocin receptor gene expression in the mouse brain and mammary gland using an oxytocin receptor-LacZ reporter mouse. Neuroscience 2003; 122: 155-167.
36. Schaffler A, Binart N, Scholmerich J, Buchler C,. Hypothesis paper brain talks with fat-evidence for a hypothalamic-pituitary-adipose axis? Neuropeptides 2005; 39: 363-367.
37. Elabd C, Basillais A, Beaupied H, et al. Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis. Stem Cells 2008; 26: 2399-2407.
38. Camerino C,. Low sympathetic tone and obese phenotype in oxytocin-deficient mice. Obesity 2009; 17: 980-984.
39. Eckertova M, Ondrejcakova M, Krskova K, Zorad S, Jezova D,. Subchronic treatment of rats with oxytocin results in improved adipocyte differentiation and increased gene expression of factors involved in adipogenesis. Br J Pharmacol 2011; 162: 452-463.
40. Carter CS, Boone EM, Pournajafi-Nazarloo H, Bales KL,. Consequences of early experiences and exposure to oxytocin and vasopressin are sexually dimorphic. Develop Neurosci 2009; 31: 332-341.