Heparin dose adjustment required to maintain goal-activated partial thromboplastin time during therapeutic hypothermia

Journal of Critical Care

Volumn 30, Issue 3, 2015, Pages 574-578

  Fevold, Ryan T ^a   Leung, Yuk Ting Lydia ^a   Garofoli, Adrian C ^a   White, Roger D ^a   Barsness, Gregory W ^a   Dierkhising, Ross A ^a   Ou, Narith N ^a  

^a MAYO CLINIC   (United States)

Author keywords

Cardiac arrest; Therapeutic hypothermia; Unfractionated heparin

Indexed keywords

HEMOGLOBIN; HEPARIN; ANTICOAGULANT AGENT;

ADULT; ARTICLE; CONTROLLED STUDY; CORE TEMPERATURE; DOSE RESPONSE; ERYTHROCYTE TRANSFUSION; FEMALE; HEMOGLOBIN BLOOD LEVEL; HUMAN; INDUCED HYPOTHERMIA; MAJOR CLINICAL STUDY; MALE; NOMOGRAM; PARTIAL THROMBOPLASTIN TIME; PREDICTION; RETROSPECTIVE STUDY; STATISTICAL MODEL; BLOOD; HEART ARREST; MIDDLE AGED;

ANTICOAGULANTS; FEMALE; HEART ARREST; HEPARIN; HUMANS; HYPOTHERMIA, INDUCED; LINEAR MODELS; MALE; MIDDLE AGED; NOMOGRAMS; PARTIAL THROMBOPLASTIN TIME; RETROSPECTIVE STUDIES;

EID: 84928582284     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2015.01.016     Document Type: Article

References (19)

1. Peberdy M.A., Callaway C.W., Neumar R.W., Geocadin R.G., Zimmerman J.L., Donnino M., et al. Part 9: Post-Cardiac Arrest Care: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010, 122(Suppl 3):S768-S786.
2. van den Broek M.P., Groenendaal F., Egberts A.C., Rademaker C.M. Effects of hypothermia on pharmacokinetics and pharmacodynamics: a systematic review of preclinical and clinical studies. Clin Pharmacokinet 2010, 49(5):277-294.
3. Arpino P.A., Greer D.M. Practical pharmacologic aspects of therapeutic hypothermia after cardiac arrest. Pharmacotherapy 2008, 28(1):102-111.
4. Wahby K.A., Jhajhria S., Dalal B.D., Soubani A.O. Heparin dosing in critically ill patients undergoing therapeutic hypothermia following cardiac arrest. Resuscitation 2014, 85(4):533-537.
5. Garcia D.A., Baglin T.P., Weitz J.I., Samama M.M. Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012, 141(2 Suppl):e24S-e43S.
6. Fugate J.E., Wijdicks E.F., Mandrekar J., Claassen D.O., Manno E.M., White R.D., et al. Predictors of neurologic outcome in hypothermia after cardiac arrest. Ann Neurol 2010, 68(6):907-914.
7. Bauer S.R., Ou N.N., Dreesman B.J., Armon J.J., Anderson J.A., Cha S.S., et al. Effect of body mass index on bleeding frequency and activated partial thromboplastin time in weight-based dosing of unfractionated heparin: a retrospective cohort study. Mayo Clin Proc 2009, 84(12):1073-1078.
8. Anderson J.L., Adams C.D., Antman E.M., Bridges C.R., Califf R.M., Casey D.E., et al. 2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013, 61(23):e179-e347.
9. Valeri C.R., MacGregor H., Cassidy G., Tinney R., Pompei F. Effects of temperature on bleeding time and clotting time in normal male and female volunteers. Crit Care Med 1995, 23(4):698-704.
10. Spiel A.O., Kliegel A., Janata A., Uray T., Mayr F.B., Laggner A.N., et al. Hemostasis in cardiac arrest patients treated with mild hypothermia initiated by cold fluids. Resuscitation 2009, 80(7):762-765.
11. Schefold J.C., Storm C., Joerres A., Hasper D. Mild therapeutic hypothermia after cardiac arrest and the risk of bleeding in patients with acute myocardial infarction. Int J Cardiol 2009, 132(3):387-391.
12. Polderman K. Is therapeutic hypothermia immunosuppressive?. Crit Care 2012, 16(Suppl 2):A8.
13. Reed R.L., Bracey A.W., Hudson J.D., Miller T.A., Fischer R.P. Hypothermia and Blood Coagulation: Dissociation Between Enzyme Activity and Clotting Factor Levels. Circ Shock 1990, 32(2):141-152.
14. Kettner S.C., Stizwohl C., Zimpfer M., Kozek S.A., Holzer A., Spiss C.K., et al. The Effect of Graded Hypothermia (36C-32C) on Hemostatis in Anesthetized Patients Without Surgical Trauma. Anesth Analg 2003, 96:1772-1776.
15. Staab D.B., Sorensen V.J., Fath J.J., Raman S.B.K., Horst H.M., Obeid F.N. Coagulation Defects Resulting From Ambient Temperature-Induced Hypothermia. J Trauma 1994, 36(5):634-638.
16. Despotis G.J., Summerfield A.L., Joist J.H., Goodnough L.T., Santoro S.A., Spitznagel E., et al. Comparison of activated coagulation time and whole blood heparin measurements with laboratory plasma anti-Xa heparin concentration in patients having cardiac operations. J Thorac Cardiovasc Surg 1994, 108(6):1076-1082.
17. Cohen E., Camerlengo L., Dearing J. Activated clotting times and cardiopulmonary bypass I: the effect of hemodilution and hypothermia upon activated clotting time. J Extra Corpor Technol 1980, 12(6):139-141.
18. Tian L., Coffin S., Sutton R., Murray D., Olson J., Ploessl J. The Effect of Hypothermia on Heparin Anticoagulation as Measured by Activated Clotting Time and Factor Xa Inhibition. J Extra Corpor Technol 1995, 27(4):192-196.
19. Stensrud P.E., Nuttall G.A., de Castro M.A., Abel M.D., Ereth M.H., Oliver W.C., et al. A Prospective, Randomized Study of Cardiopulmonary Bypass Temperature and Blood Transfusion. Ann Thorac Cardiovasc Surg 1999, 67:711-715.