Confocal laser endomicroscopy for the differential diagnosis of ulcerative colitis and Crohn's disease: A pilot study

Endoscopy

Volumn 361, Issue , 2014, Pages 437-443

  Tontini, Gian Eugenio ^a,b   Mudter, Jonas ^a   Vieth, Michael ^c   Atreya, Raja ^a   Günther, Claudia ^a   Zopf, Yurdagül ^a   Wildner, Dane ^a   Kiesslich, Ralf ^d   Vecchi, Maurizio ^b,e   Neurath, Markus F ^a   Neumann, Helmut ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b IRCCS POLICLINICO SAN DONATO   (Italy)

^c INSTITUTE OF PATHOLOGY   (Germany)

^d Katharina Kasper Hospital   (Germany)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; COLONOSCOPY; CONFOCAL LASER MICROSCOPY; CROHN DISEASE; DIFFERENTIAL DIAGNOSIS; DISCONTINUOUS CRYPT ARCHITECTURAL ABNORMALITY; DISCONTINUOUS INFLAMMATION; DISEASE ACTIVITY; ENDOSCOPY; FEMALE; FOCAL CRYPTITIS; GOLD STANDARD; HISTOPATHOLOGY; HUMAN; INFLAMMATORY BOWEL DISEASE; INTESTINE PREPARATION; LAMINA PROPRIA; MAJOR CLINICAL STUDY; MALE; PILOT STUDY; PREDICTION; PROSPECTIVE STUDY; SCORING SYSTEM; SCREENING TEST; ULCERATIVE COLITIS; ADOLESCENT; CLINICAL TRIAL; CONFOCAL MICROSCOPY; INTESTINE MUCOSA; MIDDLE AGED; PATHOLOGY; PROCEDURES; YOUNG ADULT; CONFOCAL LASER ENDOMICROSCOPY SCORING SYSTEM; CONTROLLED STUDY; DENSITY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; GRANULOMA; HUMAN TISSUE; INFLAMMATION; PREDICTIVE VALUE; PRESERVATION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

FLUORESCEIN; FLUORESCENT DYE; MUCIN;

ADOLESCENT; ADULT; AGED; COLITIS, ULCERATIVE; COLONOSCOPY; CROHN DISEASE; DIAGNOSIS, DIFFERENTIAL; FEMALE; FLUORESCEIN; FLUORESCENT DYES; HUMANS; INTESTINAL MUCOSA; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; PILOT PROJECTS; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84928541496     PISSN: 0013726X     EISSN: 14388812     Source Type: Journal    
DOI: 10.1055/s-0034-1391226     Document Type: Article

References (40)

1. Abraham C, Cho JH. Inflammatory bowel disease. N Engl J Med 2009; 361: 2066-2078
2. Dignass A, Lindsay JO, Sturm A et al. Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management. J Crohns Colitis 2012; 6: 991-1030
3. Dignass A, Van Assche G, Lindsay JO et al. The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: current management. J Crohns Colitis 2010; 4: 28-62 (Erratum in: J Crohns Colitis 2010; 4: 353)
4. Mowat C, Cole A, Windsor A et al. Guidelines for the management of inflammatory bowel disease in adults. Gut 2011; 60: 571-607
5. Magro F, Langner C, Driessen A et al. European consensus on the histopathology of inflammatory bowel disease. J Crohns Colitis 2013; 7: 827-851
6. Silverberg MS, Satsangi J, Ahmad T et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a working party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 2005; 19: 5-36 (Suppl A)
7. Meucci G. What is the incidence, prevalence, and natural history of indeterminate colitis? Inflamm Bowel Dis 2008; 14: 159-160 Erratum in: Inflamm Bowel Dis 2009; 15: 1438-1447
8. Neumann H, Kiesslich R, Wallace MB et al. Confocal laser endomicroscopy: technical advances and clinical applications. Gastroenterology 2010; 139: 388-392
9. Watanabe O, Ando T, Maeda O et al. Confocal endomicroscopy in patients with ulcerative colitis. J Gastroenterol Hepatol 2008; 23: 286-90
10. Li CQ, Xie XJ, Yu T et al. Classification of inflammation activity in ulcerative colitis by confocal laser endomicroscopy. Am J Gastroenterol 2010; 105: 1391-1396
11. Neumann H, Vieth M, Atreya R et al. Assessment of Crohn's disease activity by confocal laser endomicroscopy. Inflamm Bowel Dis 2012; 18: 2261-2269
12. Geboes K. What histologic features best differentiate Crohn's disease from ulcerative colitis? Inflamm Bowel Dis 2008; 14: 168-169
13. Liu JJ, Wong K, Thiesen AL et al. Increased epithelial gaps in the small intestines of patients with inflammatory bowel disease: density matters. Gastrointest Endosc 2011; 73: 1174-1180
14. Trovato C, Sonzogni A, Fiori G et al. Confocal laser endomicroscopy for the detection of mucosal changes in ileal pouch after restorative proctocolectomy. Dig Liver Dis 2009; 41: 578-585
15. Kiesslich R, Duckworth CA , Moussata D et al. Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease. Gut 2012; 61: 1146-1153
16. Lai EJ, Calderwood AH, Doros G et al. The Boston bowel preparation scale: a valid and reliable instrument for colonoscopy-oriented research. Gastrointest Endosc 2009; 69: 620-625
17. D'Haens G, Sandborn WJ, Feagan BG et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology 2007; 132: 763-786
18. Mary JY, Modigliani R. Development and validation of an endoscopic index of the severity for Crohn's disease: a prospective multicentre study. Groupe d'Etudes Therapeutiques des Affections Inflammatoires du Tube Digestif (GETAID). Gut 1989; 30: 983-989
19. Sipponen T, Nuutinen H, Turunen U et al. Endoscopic evaluation of Crohn's disease activity: comparison of the CDEIS and the SES-CD. Inflamm Bowel Dis 2010; 16: 2131-2136
20. Wallace MB, Meining A, Canto MI et al. The safety of intravenous fluorescein for confocal laser endomicroscopy in the gastrointestinal tract. Aliment Pharmacol Ther 2010; 31: 548-552
21. Kiesslich R, Burg J, Vieth M et al. Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo. Gastroenterology 2004; 127: 706-713
22. Wallace M, Lauwers GY, Chen Y et al. Miami classification for probe-based confocal laser endomicroscopy. Endoscopy 2011; 43: 882-891
23. Pera A , Bellando P, Caldera D et al. Colonoscopy in inflammatory bowel disease. Diagnostic accuracy and proposal of an endoscopic score. Gastroenterology 1987; 92: 181-185
24. Tontini GE, Bisschops R, Neumann H. Endoscopic scoring systems for inflammatory bowel disease: pros and cons. Expert Rev Gastroenterol Hepatol 2014; 8: 543-554
25. Neurath MF, Travis SP. Mucosal healing in inflammatory bowel diseases: a systematic review. Gut 2012; 61: 1619-1635
26. Cominelli F. Inhibition of leukocyte trafficking in inflammatory bowel disease. N Engl J Med 2013; 369: 775-776
27. Günther C, Martini E, Wittkopf N et al. Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis. Nature 2011; 477: 335-339
28. Günther C, Neumann H, Neurath MF et al. Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium. Gut 2013; 62: 1062-1071
29. Danese S, Peyrin-Biroulet L. IBD in 2013: enriching the therapeutic armamentarium for IBD. Nat Rev Gastroenterol Hepatol 2014; 11: 84-86
30. Colombel JF, Rutgeerts P, Reinisch W et al. Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 2011; 141: 1194-1201
31. Orlando A, Guglielmi FW, Cottone M et al. Clinical implications of mucosal healing in the management of patients with inflammatory bowel disease. Dig Liver Dis 2013; 45: 986-991
32. Armuzzi A, Van Assche G, Reinisch W et al. Results of the 2nd scientific workshop of the ECCO (IV): therapeutic strategies to enhance intestinal healing in inflammatory bowel disease. J Crohns Colitis 2012; 6: 492-502
33. Fazio VW, Kiran RP, Remzi FH et al. Ileal pouch anal anastomosis: analysis of outcome and quality of life in 3707 patients. Ann Surg 2013; 257: 679-685
34. Shen B. Crohn's disease of the ileal pouch: reality, diagnosis, and management. Inflamm Bowel Dis 2009; 15: 284-294
35. Moss AC, Cheifetz AS. Howoften is a diagnosis of ulcerative colitis changed to Crohn's disease and vice versa? Inflamm Bowel Dis 2008; 14: 155-156
36. Freeman HJ. Granuloma-positive Crohn's disease. Can J Gastroenterol 2007; 21: 583-587
37. Rubio CA, Orrego A, Nesi G et al. Frequency of epithelioid granulomas in colonoscopic biopsy specimens from paediatric and adult patients with Crohn's colitis. J Clin Pathol 2007; 60: 1268-1272
38. Shepherd NA. Granulomas in the diagnosis of intestinal Crohn's disease: a myth exploded? Histopathology 2002; 41: 166-168
39. Heresbach D, Alexandre JL, Branger B et al. Frequency and significance of granulomas in a cohort of incident cases of Crohn's disease. Gut 2005; 54: 215-222
40. Neumann H, Vieth M, Atreya R et al. Prospective evaluation of the learning curve of confocal laser endomicroscopy in patients with IBD. Histol Histopathol 2011; 26: 867-872