Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system

ACS Chemical Biology

Volumn 10, Issue 4, 2015, Pages 957-964

  Halili, Maria A ^a   Bachu, Prabhakar ^a   Lindahl, Fredrik ^a   Bechara, Chérine ^b   Mohanty, Biswaranjan ^c   Reid, Robert C ^a   Scanlon, Martin J ^c   Robinson, Carol V ^b   Fairlie, David P ^a   Martin, Jennifer L ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Department of Chemistry ^*  (United Kingdom)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; CYSTEINE DERIVATIVE; DSBA PROTEIN; DSBB PROTEIN; LYSINE DERIVATIVE; THIOESTER; THIOL; THIOREDOXIN; UBIQUINONE; UNCLASSIFIED DRUG; VINYL DERIVATIVE; VIRULENCE FACTOR; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CYSTEINE; DISULFIDE; DSBA PROTEIN, E COLI; DSBB PROTEIN, BACTERIA; ESCHERICHIA COLI PROTEIN; LYSINE; MEMBRANE PROTEIN; MOLECULAR LIBRARY; PROTEIN DISULFIDE ISOMERASE;

ARTICLE; CHEMICAL MODIFICATION; COVALENT BOND; DISULFIDE BOND; ENZYME MECHANISM; ENZYME SPECIFICITY; ESCHERICHIA COLI; IC50; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DESIGN; HUMAN; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; PRECLINICAL STUDY; PROCEDURES; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BACTERIA (MICROORGANISMS);

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CYSTEINE; DISULFIDES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; LYSINE; MEMBRANE PROTEINS; PROTEIN DISULFIDE-ISOMERASES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOREDOXINS; UBIQUINONE;

EID: 84928479130     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500988r     Document Type: Article

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