Prophylactic administration of fucoidan represses cancer metastasis by inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in Lewis tumor-bearing mice

Marine Drugs

Volumn 13, Issue 4, 2015, Pages 1882-1900

  Huang, Tse Hung ^a,b   Chiu, Yi Han ^c   Chan, Yi Lin ^d   Chiu, Ya Huang ^c,e   Wang, Hang ^c,f   Huang, Kuo Chin ^g   Li, Tsung Lin ^h   Hsu, Kuang Hung ^b   Wu, Chang Jer ^c  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

^d CHINESE CULTURE UNIVERSITY   (Taiwan)

^e Agricultural Technology Research Institute   (Taiwan)

^f HUNGKUANG UNIVERSITY   (Taiwan)

^g MACKAY MEDICAL COLLEGE   (Taiwan)

^h GENOMICS RESEARCH CENTER   (Taiwan)

Author keywords

Cachexia chemo preventative agent; Fucoidan; Lung carcinoma; Metastasis; Sulfated polysaccharide

Indexed keywords

FUCOIDIN; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE; VASCULOTROPIN; ANTINEOPLASTIC AGENT; MATRIX METALLOPROTEINASE INHIBITOR; POLYSACCHARIDE; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CACHEXIA; CELL MIGRATION; CELL PROLIFERATION; CELL SPREADING; CELL VIABILITY; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; LUNG CARCINOMA; LUNG METASTASIS; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TUMOR INVASION; WEIGHT REDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BROWN ALGA; C57BL MOUSE; CARCINOMA, LEWIS LUNG; CELL MOTION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; LUNG; METABOLISM; PATHOLOGY; PREVENTION AND CONTROL; SEAWEED; SECONDARY; TUMOR CELL LINE; TUMOR VOLUME;

MUS; PHAEOPHYCEAE;

ANIMALS; ANTINEOPLASTIC AGENTS; CACHEXIA; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; LUNG; MALE; MATRIX METALLOPROTEINASE INHIBITORS; MATRIX METALLOPROTEINASES; MICE, INBRED C57BL; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NF-KAPPA B; PHAEOPHYTA; POLYSACCHARIDES; SEAWEED; TUMOR BURDEN; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 84928473601     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md13041882     Document Type: Article

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