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Volumn 24, Issue 3, 2015, Pages 208-216

Progress and controversies in unraveling the glomerular filtration mechanism

Author keywords

albumin filtration; glomerular basement membrane; glomerular disease; permeability; permselectivity; podocyte; proteinuria; slit diaphragm

Indexed keywords

CARDIOVASCULAR DISEASE; ENDOTHELIUM; GLOMERULOPATHY; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION; HEMODYNAMICS; HUMAN; NONHUMAN; PATHOGENESIS; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; REVIEW; ANIMAL; GLOMERULAR FILTRATION BARRIER; GLOMERULUS; GLOMERULUS FILTRATION RATE; KIDNEY DISEASE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

EID: 84928468258     PISSN: 10624821     EISSN: 14736543     Source Type: Journal    
DOI: 10.1097/MNH.0000000000000116     Document Type: Review
Times cited : (10)

References (36)
  • 1
    • 3042856282 scopus 로고    scopus 로고
    • Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes
    • Klausen K, Borch-Johnsen K, Feldt-Rasmussen B, et al. Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes. Circulation 2004; 110:32-35.
    • (2004) Circulation , vol.110 , pp. 32-35
    • Klausen, K.1    Borch-Johnsen, K.2    Feldt-Rasmussen, B.3
  • 2
    • 0035948631 scopus 로고    scopus 로고
    • Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals
    • Gerstein HC, Mann JF, Yi Q, et al. Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA 2001; 286:421-426.
    • (2001) JAMA , vol.286 , pp. 421-426
    • Gerstein, H.C.1    Mann, J.F.2    Yi, Q.3
  • 3
    • 67649652168 scopus 로고    scopus 로고
    • Cardiovascular implications of proteinuria: An indicator of chronic kidney disease
    • Agrawal V, Marinescu V, Agarwal M, McCullough PA. Cardiovascular implications of proteinuria: an indicator of chronic kidney disease. Nat Rev Cardiol 2009; 6:301-311.
    • (2009) Nat Rev Cardiol , vol.6 , pp. 301-311
    • Agrawal, V.1    Marinescu, V.2    Agarwal, M.3    McCullough, P.A.4
  • 4
    • 0028147336 scopus 로고
    • Transport of macromolecules across microvascular walls: The two-pore theory
    • Rippe B, Haraldsson B. Transport of macromolecules across microvascular walls: the two-pore theory. Physiol Rev 1994; 74:163-219.
    • (1994) Physiol Rev , vol.74 , pp. 163-219
    • Rippe, B.1    Haraldsson, B.2
  • 5
    • 0023422845 scopus 로고
    • Hindered transport of large molecules in liquid-filled pores
    • Deen WM. Hindered transport of large molecules in liquid-filled pores. AIChE J 1987; 33:1409-1425.
    • (1987) AIChE J , vol.33 , pp. 1409-1425
    • Deen, W.M.1
  • 6
    • 0018670579 scopus 로고
    • Macromolecule transport across glomerular capillaries: Application of pore theory
    • Deen WM, Bohrer MP, Brenner BM. Macromolecule transport across glomerular capillaries: application of pore theory. Kidney Int 1979; 16:353-365.
    • (1979) Kidney Int , vol.16 , pp. 353-365
    • Deen, W.M.1    Bohrer, M.P.2    Brenner, B.M.3
  • 8
    • 84876995051 scopus 로고    scopus 로고
    • Renal albumin filtration: Alternative models to the standard physical barriers
    • Moeller MJ, Tenten V. Renal albumin filtration: alternative models to the standard physical barriers. Nature Rev Nephrol 2013; 9:266-277.
    • (2013) Nature Rev Nephrol , vol.9 , pp. 266-277
    • Moeller, M.J.1    Tenten, V.2
  • 9
    • 84875896858 scopus 로고    scopus 로고
    • Streaming potentials as novel driving force for capillary permeability
    • Moeller MJ. Streaming potentials as novel driving force for capillary permeability. Biophys J 2013; 104:1395-1396.
    • (2013) Biophys J , vol.104 , pp. 1395-1396
    • Moeller, M.J.1
  • 10
    • 84930894719 scopus 로고    scopus 로고
    • Glomerular filtration: Pores versus an electrical field
    • Moeller MJ, Kuppe C. Glomerular filtration: pores versus an electrical field. Perit Dial Int 2015; 35:5-8.
    • (2015) Perit Dial Int , vol.35 , pp. 5-8
    • Moeller, M.J.1    Kuppe, C.2
  • 11
    • 84930917984 scopus 로고    scopus 로고
    • Electrophoresis does not significantly contribute to the permeation of albumin across the glomerular filtration barrier
    • Rippe B, Oberg C. Electrophoresis does not significantly contribute to the permeation of albumin across the glomerular filtration barrier. Perit Dial Int 2015; 35:9-13.
    • (2015) Perit Dial Int , vol.35 , pp. 9-13
    • Rippe, B.1    Oberg, C.2
  • 12
    • 78649852542 scopus 로고    scopus 로고
    • A new role for charge of the glomerular capillary membrane
    • Thomson SC, Blantz RC. A new role for charge of the glomerular capillary membrane. J Am Soc Nephrol 2010; 21:2011-2013.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 2011-2013
    • Thomson, S.C.1    Blantz, R.C.2
  • 13
    • 33750999316 scopus 로고    scopus 로고
    • Overcharging, charge reversal: Chemistry or physics?
    • Lyklema J. Overcharging, charge reversal: chemistry or physics? Colloids Surfaces Physicochem Eng Aspects 2006; 291:3-12.
    • (2006) Colloids Surfaces Physicochem Eng Aspects , vol.291 , pp. 3-12
    • Lyklema, J.1
  • 14
    • 78649884695 scopus 로고    scopus 로고
    • Electrical forces determine glomerular permeability
    • Hausmann R, Kuppe C, Egger H, et al. Electrical forces determine glomerular permeability. J Am Soc Nephrol 2010; 21:2053-2058.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 2053-2058
    • Hausmann, R.1    Kuppe, C.2    Egger, H.3
  • 15
    • 77249144033 scopus 로고    scopus 로고
    • Overcharging below the nanoscale: Multivalent cations reverse the ion selectivity of a biological channel
    • Garcia-Gimenez E, Alcaraz A, Aguilella VM. Overcharging below the nanoscale: multivalent cations reverse the ion selectivity of a biological channel. Phys Rev E 2010; 81:021912.
    • (2010) Phys Rev e , vol.81 , pp. 021912
    • Garcia-Gimenez, E.1    Alcaraz, A.2    Aguilella, V.M.3
  • 16
    • 84875896601 scopus 로고    scopus 로고
    • Effects of pressure and electrical charge on macromolecular transport across bovine lens basement membrane
    • Ferrell N, Cameron KO, Groszek JJ, et al. Effects of pressure and electrical charge on macromolecular transport across bovine lens basement membrane. Biophys J 2013; 104:1476-1484.
    • (2013) Biophys J , vol.104 , pp. 1476-1484
    • Ferrell, N.1    Cameron, K.O.2    Groszek, J.J.3
  • 17
    • 84929574439 scopus 로고    scopus 로고
    • The evolution of blood pressure and the rise of mankind
    • Epub ahead of print
    • Schulte K, Kunter U, Moeller MJ. The evolution of blood pressure and the rise of mankind. Nephrol Dial Transplant 2014; pii:gfu275. doi: 10.1093/ndt/ gfu275. [Epub ahead of print].
    • (2014) Nephrol Dial Transplant
    • Schulte, K.1    Kunter, U.2    Moeller, M.J.3
  • 18
    • 0027499897 scopus 로고
    • Intra-GBMsite of the functional filtration barrier for endogenous proteins in rats
    • Fujigaki Y, Nagase M, Kobayasi S, et al. Intra-GBMsite of the functional filtration barrier for endogenous proteins in rats. Kidney Int 1993; 43:567-574.
    • (1993) Kidney Int , vol.43 , pp. 567-574
    • Fujigaki, Y.1    Nagase, M.2    Kobayasi, S.3
  • 19
    • 0025603764 scopus 로고
    • Distribution of endogenous albumin in the glomerular wall of proteinuric patients
    • Russo PA, BendayanM. Distribution of endogenous albumin in the glomerular wall of proteinuric patients. Am J Pathol 1990; 137:1481-1490.
    • (1990) Am J Pathol , vol.137 , pp. 1481-1490
    • Russo, P.A.1    Bendayan, M.2
  • 20
    • 84928498892 scopus 로고    scopus 로고
    • In vivo measurement of albumin concentration gradients within the glomerular capillary
    • Accessed 8 March 2015
    • Wang B, Sandoval RM, Molitoris BA, et al. In vivo measurement of albumin concentration gradients within the glomerular capillary. J Am Soc Nephrol [abstract supplement] 2014; 25:TH-OR118. http://www.asn-online.org/api/ download/?file=/education/kidneyweek/archives/KW14Abstracts.pdf. [Accessed 8 March 2015]
    • (2014) J Am Soc Nephrol [Abstract Supplement] , vol.25 , pp. THOR118
    • Wang, B.1    Sandoval, R.M.2    Molitoris, B.A.3
  • 21
    • 0017293323 scopus 로고
    • Distribution of endogenous albumin in the rat glomerulus: Role of hemodynamic factors in glomerular barrier function
    • Ryan GB, Karnovsky MJ. Distribution of endogenous albumin in the rat glomerulus: role of hemodynamic factors in glomerular barrier function. Kidney Int 1976; 9:36-45.
    • (1976) Kidney Int , vol.9 , pp. 36-45
    • Ryan, G.B.1    Karnovsky, M.J.2
  • 22
    • 84876522948 scopus 로고    scopus 로고
    • Glomerular endothelial surface layer acts as a barrier against albumin filtration
    • Dane MJ, van den Berg BM, AvramutMC, et al. Glomerular endothelial surface layer acts as a barrier against albumin filtration. Am J Pathol 2013; 182:1532-1540.
    • (2013) Am J Pathol , vol.182 , pp. 1532-1540
    • Dane, M.J.1    Van Den Berg, B.M.2    Avramut, M.C.3
  • 23
    • 84880925050 scopus 로고    scopus 로고
    • The glomerular basement membrane as a barrier to albumin
    • Suh JH, Miner JH. The glomerular basement membrane as a barrier to albumin. Nat Rev Nephrol 2013; 9:470-477.
    • (2013) Nat Rev Nephrol , vol.9 , pp. 470-477
    • Suh, J.H.1    Miner, J.H.2
  • 24
    • 0020051866 scopus 로고
    • Effects of aging on the glomerular capillaries, blood pressure, and renal function in rats
    • Schurek HJ, Panzer J, Wiemeyer A, et al. Effects of aging on the glomerular capillaries, blood pressure, and renal function in rats. Contrib Nephrol 1982; 30:157-162.
    • (1982) Contrib Nephrol , vol.30 , pp. 157-162
    • Schurek, H.J.1    Panzer, J.2    Wiemeyer, A.3
  • 25
    • 42149122041 scopus 로고    scopus 로고
    • Properties of the glomerular barrier and mechanisms of proteinuria
    • Haraldsson B, Nystrom J, Deen WM. Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev 2008; 88:451-487.
    • (2008) Physiol Rev , vol.88 , pp. 451-487
    • Haraldsson, B.1    Nystrom, J.2    Deen, W.M.3
  • 26
    • 0031804133 scopus 로고    scopus 로고
    • Assessment of the charge selectivity of glomerular basement membrane using Ficoll sulfate
    • Bolton GR, Deen WM, Daniels BS. Assessment of the charge selectivity of glomerular basement membrane using Ficoll sulfate. Am J Physiol 1998; 274 (5 Pt 2):F889-F896.
    • (1998) Am J Physiol , vol.274 , Issue.5 , pp. F889-F896
    • Bolton, G.R.1    Deen, W.M.2    Daniels, B.S.3
  • 27
    • 0037609543 scopus 로고    scopus 로고
    • Glomerular filtration rate dependence of sieving of albumin and some neutral proteins in rat kidneys
    • Lund U, Rippe A, Venturoli D, et al. Glomerular filtration rate dependence of sieving of albumin and some neutral proteins in rat kidneys. Am J Physiol Renal Physiol 2003; 284:F1226-F1234.
    • (2003) Am J Physiol Renal Physiol , vol.284 , pp. F1226-F1234
    • Lund, U.1    Rippe, A.2    Venturoli, D.3
  • 28
    • 38149061339 scopus 로고    scopus 로고
    • Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria
    • van den Hoven MJ, Wijnhoven TJ, Li JP, et al. Reduction of anionic sites in the glomerular basement membrane by heparanase does not lead to proteinuria. Kidney Int 2008; 73:278-287.
    • (2008) Kidney Int , vol.73 , pp. 278-287
    • Van Den Hoven, M.J.1    Wijnhoven, T.J.2    Li, J.P.3
  • 29
    • 34547680445 scopus 로고    scopus 로고
    • Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity
    • Harvey SJ, Jarad G, Cunningham J, et al. Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity. Am J Pathol 2007; 171:139-152.
    • (2007) Am J Pathol , vol.171 , pp. 139-152
    • Harvey, S.J.1    Jarad, G.2    Cunningham, J.3
  • 30
    • 67651089928 scopus 로고    scopus 로고
    • Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane
    • Goldberg S, Harvey SJ, Cunningham J, et al. Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulfate from the glomerular basement membrane. Nephrol Dial Transplant 2009; 24:2044-2051.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 2044-2051
    • Goldberg, S.1    Harvey, S.J.2    Cunningham, J.3
  • 31
    • 84906572644 scopus 로고    scopus 로고
    • Reply: Podocytes are key-although albumin never reaches the slit diaphragm
    • Moeller MJ, Tanner GA. Reply: podocytes are key-although albumin never reaches the slit diaphragm. Nat Rev Nephrol 2014; 10:180.
    • (2014) Nat Rev Nephrol , vol.10 , pp. 180
    • Moeller, M.J.1    Tanner, G.A.2
  • 32
    • 84878619489 scopus 로고    scopus 로고
    • The role of the podocyte in albumin filtration
    • Comprehensive review of podocyte signaling and function
    • Brinkkoetter PT, Ising C, Benzing T. The role of the podocyte in albumin filtration. Nat Rev Nephrol 2013; 9:328-336. Comprehensive review of podocyte signaling and function.
    • (2013) Nat Rev Nephrol , vol.9 , pp. 328-336
    • Brinkkoetter, P.T.1    Ising, C.2    Benzing, T.3
  • 33
    • 65949118275 scopus 로고    scopus 로고
    • Development of kidney glomerular endothelial cells and their role in basement membrane assembly
    • Abrahamson DR. Development of kidney glomerular endothelial cells and their role in basement membrane assembly. Organogenesis 2009; 5:275-287.
    • (2009) Organogenesis , vol.5 , pp. 275-287
    • Abrahamson, D.R.1
  • 34
    • 33645548140 scopus 로고    scopus 로고
    • Transgenic isolation of skeletal muscle and kidney defects in laminin beta2 mutant mice: Implications for Pierson syndrome
    • Miner JH, Go G, Cunningham J, et al. Transgenic isolation of skeletal muscle and kidney defects in laminin beta2 mutant mice: implications for Pierson syndrome. Development 2006; 133:967-975.
    • (2006) Development , vol.133 , pp. 967-975
    • Miner, J.H.1    Go, G.2    Cunningham, J.3
  • 35
    • 0017838170 scopus 로고
    • Permselectivity of the glomerular capillary wall. Facilitated filtration of circulating polycations
    • Bohrer MP, Baylis C, Humes HD, et al. Permselectivity of the glomerular capillary wall. Facilitated filtration of circulating polycations. J Clin Invest 1978; 61:72-78.
    • (1978) J Clin Invest , vol.61 , pp. 72-78
    • Bohrer, M.P.1    Baylis, C.2    Humes, H.D.3
  • 36
    • 0034998158 scopus 로고    scopus 로고
    • A quantitative analysis of the glomerular charge barrier in the rat
    • Sorensson J, Ohlson M, Haraldsson B. A quantitative analysis of the glomerular charge barrier in the rat. Am J Physiol Renal Physiol 2001; 280:F646-F656.
    • (2001) Am J Physiol Renal Physiol , vol.280 , pp. F646-F656
    • Sorensson, J.1    Ohlson, M.2    Haraldsson, B.3


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