Antipsychotic drugs and risks of myocardial infarction: A self-controlled case series study

European Heart Journal

Volumn 36, Issue 16, 2015, Pages 984-992

  Brauer, Ruth ^a   Smeeth, Liam ^a   Anaya Izquierdo, Karim ^a   Timmis, Adam ^b   Denaxas, Spiros C ^c   Farrington, C Paddy ^d   Whitaker, Heather ^d   Hemingway, Harry ^c   Douglas, Ian ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b BARTS HEALTH NHS TRUST   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d OPEN UNIVERSITY   (United Kingdom)

Author keywords

Antipsychotic agents; Case control study; Myocardial infarction; Self controlled case series

Indexed keywords

NEUROLEPTIC AGENT;

AGED; ALCOHOL CONSUMPTION; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR RISK; COMORBIDITY; CONTROLLED STUDY; DEMENTIA; DIABETES MELLITUS; DYSLIPIDEMIA; FEMALE; FOLLOW UP; HEART INFARCTION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OBESITY; OUTCOME ASSESSMENT; PRESCRIPTION; PRIORITY JOURNAL; SECONDARY ANALYSIS; SMOKING; ADULT; CASE CONTROL STUDY; CHEMICALLY INDUCED; MENTAL DISORDERS; MIDDLE AGED; RISK FACTOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIPSYCHOTIC AGENTS; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; MENTAL DISORDERS; MIDDLE AGED; MYOCARDIAL INFARCTION; RISK FACTORS;

EID: 84928411075     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehu263     Document Type: Article

References (25)

1. The Health and Social Care Information Centre. Prescriptions Dispensed in the Community: England, Statistics for 2001 to 2011. https://catalogue.ic.nhs.uk/publications/prescribing/primary/pres-disp-com-eng-2001-11/pres-disp-com-eng-2001-11-rep.pdf (28 April 2012).
2. Brodaty H, Ames D, Snowdon J,Woodward M, Kirwan J, Clarnette R, Lee E, Lyons B, Grossman F.Arandomized placebo-controlled trial of risperidone for the treatment of aggression, agitation, and psychosis of dementia. J Clin Psychiatry2003;64:134-143.
3. Health Canada. Important drug safety information: RISPERDAL∗ (risperidone) and cerebrovascular adverse events in placebo-controlled dementia trials. 2002. http://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2002/14720a-eng.php (12 January 2013).
4. Gill SS, Rochon PA, Herrmann N, Lee PE, Sykora K, Gunraj N, Normand SL, Gurwitz JH, Marras C, Wodchis WP, Mamdani M. Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study. BMJ 2005;330:445.
5. Douglas IJ, Smeeth L. Exposure to antipsychotics and risk of stroke: self-controlled case series study. BMJ 2008;337:a1227.
6. RayWA, Chung CP, Murray KT, Hall K, Stein CM. Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med 2009;360:225-235.
7. Pariente A, Fourrier-Reglat A, Ducruet T, Farrington P, Beland SG, Dartigues JF, Moore N, Moride Y. Antipsychotic use and myocardial infarction in older patients with treated dementia. Arch Intern Med 2012;172:648-653. discussion 654-5.
8. Brauer R, Douglas I, Smeeth L. The association between antipsychotic agents and the risk ofmyocardial infarction: a systematic review. Br J Clin Pharmacol 2011;72:871-878.
9. Goldstein BI, Fagiolini A, Houck P, Kupfer DJ. Cardiovascular disease and hypertension among adults with bipolar I disorder in the United States. Bipolar Disord 2009;11: 657-662.
10. Huang KL, Su TP, Chen TJ, Chou YH, Bai YM. Comorbidity of cardiovascular diseases with mood and anxiety disorder: a population based 4-year study. Psychiatry Clin Neurosci 2009;63:401-409.
11. Jakobsen AH, Foldager L, Parker G, Munk-Jorgensen P. Quantifying links between acute myocardial infarction and depression, anxiety and schizophrenia using case register databases. J Affect Disord 2008;109:177-181.
12. Whitaker HJ, FarringtonCP, Spiessens B, Musonda P. Tutorial in biostatistics: the selfcontrolled case series method. Stat Med 2006;25:1768-1797.
13. Denaxas SC, George J, Herrett E, Shah AD, Kalra D, Hingorani AD, Kivimaki M, Timmis AD, Smeeth L, Hemingway H. Data Resource Profile: Cardiovascular disease research using linked bespoke studies and electronic health records (CALIBER). Int J Epidemiol 2012;41:1625-1638.
14. Clinical Practice Research Datalink. Observational data. http://www.cprd.com/ObservationalData/CodedData.asp#Primarycare (September 2012).
15. Herrett E, Shah AD, Boggon R, Denaxas S, Smeeth L, van Staa T, Timmis A, Hemingway H. Completeness and diagnostic validity of recording acute myocardial infarction events in primary care, hospital care, disease registry, and national mortality records: cohort study. BMJ 2013;346:f2350.
16. Farrington CP, Anaya-Izquierdo K, Whitaker HJ, Hocine MN, Dougas I, Smeeth L. Self-controlled case series analysis with event-dependent observation periods. J Am Statist Assoc 2011;106:9 (Epub 24 Jan 2012).
17. Straus SM, Bleumink GS, Dieleman JP, van der Lei J, tJong GW, Kingma JH, Sturkenboom MC, Stricker BH. Antipsychotics and the risk of sudden cardiac death. Arch Inter Med 2004;164:1293-1297.
18. Hennessy S, Bilker WB, Knauss JS, Margolis DJ, Kimmel SE, Reynolds RF, Glasser DB, Morrison MF, Strom BL. Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data. BMJ 2002;325:1070.
19. Enger C,Weatherby L, Reynolds RF, Glasser DB,WalkerAM. Serious cardiovascular events and mortality among patients with schizophrenia. J Nerv Ment Dis 2004;192: 19-27.
20. Nakagawa S, Pedersen L, Olsen ML, Mortensen PB, Sorensen HT, Johnsen SP. Antipsychotics and risk of first-time hospitalization for myocardial infarction: a population-based case-control study. J Inter Med 2006;260:451-458.
21. Bresee LC, Majumdar SR, Patten SB, Johnson JA. Utilization of general and specialized cardiac care by people with schizophrenia. Psychiatr Serv 2012;63:237-242.
22. Huybrechts KF, Schneeweiss S, Gerhard T, Olfson M, Avorn J, Levin R, Lucas JA, Crystal S. Comparative safety of antipsychotic medications in nursing home residents. J Am Geriatr Soc 2012;60:420-429.
23. Farrington CP, Whitaker HJ, Hocine MN. Case series analysis for censored, perturbed, or curtailed post-event exposures. Biostatistics 2009;10:3-16.
24. JohnsenSP, LarssonH,TaroneRE,McLaughlinJK,NorgardB, Friis S,SørensenHT.Riskof hospitalization for myocardial infarction among users of rofecoxib, celecoxib, and other NSAIDs: a population-based case-control study. Arch Inter Med 2005;165:978-984.
25. Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RS, Davis CE, Severe J, Hsiao JK; CATIE Investigators. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005;353: 1209-1223.