Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts

Nature

Volumn 520, Issue 7547, 2015, Pages 329-332

  Tsubogo, Tetsu ^a   Oyamada, Hidekazu ^a   Kobayashi, Shu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 3 PHENYLBUTYRIC ACID; ROLIPRAM; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 4-AMINO-3-PHENYLBUTYRIC ACID; ANTIDEPRESSANT AGENT;

CATALYST; CHEMICAL METHOD; DRUG DEVELOPMENT; HETEROGENEOUS MEDIUM; MANUFACTURING; PHARMACEUTICAL INDUSTRY; TRANSFORMATION;

ARTICLE; CATALYST; CONTINUOUS FLOW SYNTHESIS; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; DEVICES; PROCEDURES; STEREOISOMERISM; SYNTHESIS;

ANTIDEPRESSIVE AGENTS; CATALYSIS; CHEMISTRY TECHNIQUES, SYNTHETIC; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; MOLECULAR STRUCTURE; ROLIPRAM; STEREOISOMERISM;

EID: 84928380956     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14343     Document Type: Article

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