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Volumn 24, Issue 5, 2015, Pages 386-388
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The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation
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Author keywords
Akt; Clotrimazole; Extracellular signal regulated kinase; Melanogenesis; Tyrosinase degradation
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Indexed keywords
CLOTRIMAZOLE;
DEPIGMENTING AGENT;
MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR;
MITOGEN ACTIVATED PROTEIN KINASE;
MONOPHENOL MONOOXYGENASE;
PHOSPHATIDYLINOSITOL 3 KINASE;
PROTEIN KINASE B;
ANTIFUNGAL AGENT;
MELANIN;
MESSENGER RNA;
ANIMAL CELL;
CELL FREE SYSTEM;
CONCENTRATION RESPONSE;
CYTOTOXICITY;
DOWN REGULATION;
DRUG EFFECT;
ENZYME ACTIVATION;
ENZYME ACTIVITY;
ENZYME DEGRADATION;
ENZYME INHIBITION;
ENZYME PHOSPHORYLATION;
ENZYME REPRESSION;
HUMAN;
HUMAN CELL;
INCUBATION TIME;
LETTER;
MELANOGENESIS;
NONHUMAN;
ANIMAL;
BIOSYNTHESIS;
CELL LINE;
DRUG EFFECTS;
GENETICS;
MELANOCYTE;
METABOLISM;
MOUSE;
PROTEIN DEGRADATION;
SIGNAL TRANSDUCTION;
SKIN PIGMENTATION;
ANIMALS;
ANTIFUNGAL AGENTS;
CELL LINE;
CLOTRIMAZOLE;
HUMANS;
MAP KINASE SIGNALING SYSTEM;
MELANINS;
MELANOCYTES;
MICE;
MONOPHENOL MONOOXYGENASE;
PHOSPHATIDYLINOSITOL 3-KINASES;
PROTEOLYSIS;
PROTO-ONCOGENE PROTEINS C-AKT;
RNA, MESSENGER;
SKIN PIGMENTATION;
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EID: 84928353036
PISSN: 09066705
EISSN: 16000625
Source Type: Journal
DOI: 10.1111/exd.12669 Document Type: Article |
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Times cited : (17)
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References (9)
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