Endothelin-1 overexpression and endothelial nitric oxide synthase knock-out induce different pathological responses in the heart of male and female mice

Life Sciences

Volumn 118, Issue 2, 2014, Pages 219-225

  Vignon Zellweger, Nicolas ^a   Relle, Katharina ^a   Rahnenführer, Jan ^a   Schwab, Karima ^a   Hocher, Berthold ^b   Theuring, Franz ^a  

^a DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^b UNIVERSITY OF POTSDAM   (Germany)

Author keywords

Cardiac function; Endothelin 1; Nitric oxide; Sexual dimorphism

Indexed keywords

COLLAGEN TYPE 1; COPPER ZINC SUPEROXIDE DISMUTASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; GELATINASE A; GELATINASE B; SUPEROXIDE DISMUTASE; TISSUE INHIBITOR OF METALLOPROTEINASE 4; COLLAGEN; MESSENGER RNA; METALLOPROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GENE OVEREXPRESSION; GENETIC MANIPULATION; HEART CATHETERIZATION; HEART FUNCTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART MUSCLE FIBROSIS; HEART VENTRICLE; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; IMMUNOHISTOCHEMISTRY; LEFT VENTRICULAR END DIASTOLIC BLOOD PRESSURE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; UPREGULATION; ANIMAL; BLOOD PRESSURE; DEFICIENCY; ENZYMOLOGY; FIBROSIS; GENE EXPRESSION REGULATION; GENETICS; HEART FUNCTION TEST; HEART MUSCLE; HEART MUSCLE CELL; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; SEXUAL DEVELOPMENT; SYSTOLE;

ANIMALS; BLOOD PRESSURE; COLLAGEN; ENDOTHELIN-1; FEMALE; FIBROSIS; GENE EXPRESSION REGULATION; HEART FUNCTION TESTS; MALE; METALLOPROTEASES; MICE, KNOCKOUT; MYOCARDIUM; MYOCYTES, CARDIAC; NITRIC OXIDE SYNTHASE TYPE III; RNA, MESSENGER; SEX CHARACTERISTICS; SYSTOLE;

EID: 84928238848     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.12.003     Document Type: Article

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