Immune phenomena in glaucoma and conformational disorders: Why is the second eye not involved?

Journal of Glaucoma

Volumn 23, Issue 8, 2014, Pages S59-S61

  Kuehn, Markus H ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Autoimmunity; Exfoliation syndrome; Innate immunity; Parainflammation

Indexed keywords

AUTOANTIBODY; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3; COMPLEMENT MEMBRANE ATTACK COMPLEX; IMMUNOGLOBULIN G;

ANTIBODY BLOOD LEVEL; AUTOIMMUNITY; CELL DEGENERATION; EXPERIMENTAL GLAUCOMA; EYE; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RETINA GANGLION CELL; REVIEW; ANIMAL; BLOOD; IMMUNOLOGY; INNATE IMMUNITY; OPEN ANGLE GLAUCOMA; PHYSIOLOGY; PSEUDOEXFOLIATION;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNITY; EXFOLIATION SYNDROME; GLAUCOMA, OPEN-ANGLE; HUMANS; IMMUNITY, INNATE;

EID: 84928234729     PISSN: 10570829     EISSN: 1536481X     Source Type: Journal    
DOI: 10.1097/IJG.0000000000000115     Document Type: Review

References (24)

1. Morrison JC, Moore CG, Deppmeier LM, et al. A rat model of chronic pressure-induced optic nerve damage. Exp Eye Res. 1997;64:85-96.
2. Moreno MC, Marcos HJ, Oscar Croxatto J, et al. A new experimental model of glaucoma in rats through intracameral injections of hyaluronic acid. Exp Eye Res. 2005;81:71-80.
3. Grozdanic SD, Kwon YH, Sakaguchi DS, et al. Functional evaluation of retina and optic nerve in the rat model of chronic ocular hypertension. Exp Eye Res. 2004;79:75-83.
4. Chen H, Wei X, Cho KS, et al. Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse. Invest Ophthalmol Vis sci. 2011;52:36-44.
5. Rasmussen CA, Kaufman PL. Primate glaucoma models. J Glaucoma. 2005;14:311-314.
6. Gallego BI, Salazar JJ, de Hoz R, et al. IOP induces upregulation of GFAP and MHC-II and microglia reactivity in mice retina contralateral to experimental glaucoma. J Neuroinflammation. 2012;9:92-110.
7. Kuehn MH, Kim CY, Jiang B, et al. Disruption of the complement cascade delays retinal ganglion cell death following retinal ischemia-reperfusion. Exp Eye Res. 2008;87:89-95.
8. Yucel YH, Zhang Q, Weinreb RN, et al. Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma. Prog Retin Eye Res. 2003;22:465-481.
9. Yucel YH, Zhang Q, Weinreb RN, et al. Atrophy of relay neurons in magno-and parvocellular layers in the lateral geniculate nucleus in experimental glaucoma. Invest Ophthalmol Vis sci. 2001;42:3216-3222.
10. Gupta N, Greenberg G, de Tilly LN, et al. Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging. Br J Ophthalmol. 2009;93: 56-60.
11. Altintas O, Yuksel N, Sonmez GT, et al. Serum antiphospholipid antibody levels in pseudoexfoliation. J Glaucoma. 2012;21:326-330.
12. Dervan EW, Chen H, Ho SL, et al. Protein macroarray profiling of serum autoantibodies in pseudoexfoliation glaucoma. Invest Ophthalmol Vis sci. 2010;51:2968-2975.
13. Joachim SC, Bruns K, Lackner KJ, et al. Analysis of IgG antibody patterns against retinal antigens and antibodies to alpha-crystallin, GFAP, and alpha-enolase in sera of patients with "wet" age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2007;245:619-626.
14. Gramlich OW, Beck S, von Thun Und Hohenstein-Blaul N, et al. Enhanced insight into the autoimmune component of glaucoma: IgG autoantibody accumulation and pro-inflammatory conditions in human glaucomatous retina. PloS One. 2013;8:e57557.
15. Wax MB, Tezel G, Yang J, et al. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J Neuroscience. 2008;28:12085-12096.
16. Laspas P, Gramlich OW, Muller HD, et al. Autoreactive antibodies and loss of retinal ganglion cells in rats induced by immunization with ocular antigens. Invest Ophthalmol Vis sci. 2011;52:8835-8848.
17. Kuehn MH, Kim CY, Ostojic J, et al. Retinal synthesis and deposition of complement components induced by ocular hypertension. Exp Eye Res. 2006;83:620-628.
18. Stasi K, Nagel D, Yang X, et al. Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes. Invest Ophthalmol Vis sci. 2006;47: 1024-1029.
19. Howell GR, Macalinao DG, Sousa GL, et al. Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma. J Clin Invest. 2011;121:1429-1444.
20. Howell GR, Soto I, Ryan M, et al. Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice. J Neuroinflammation. 2013;10:76.
21. Alexander JJ, Anderson AJ, Barnum SR, et al. The complement cascade: Yin-Yang in neuroinflammation-neuro-protection and-degeneration. J Neurochem. 2008;107:1169-1187.
22. Truedsson L, Bengtsson AA, Sturfelt G. Complement deficiencies and systemic lupus erythematosus. Autoimmunity. 2007;40:560-566.
23. Fraser DA, Tenner AJ. Directing an appropriate immune response: the role of defense collagens and other soluble pattern recognition molecules. Curr Drug Targets. 2008;9: 113-122.
24. Perry VH. Contribution of systemic inflammation to chronic neurodegeneration. Acta Neuropathologica. 2010;120: 277-286.