Anxiety is not associated with the risk of dementia or cognitive decline: The rotterdam study

American Journal of Geriatric Psychiatry

Volumn 22, Issue 12, 2014, Pages 1382-1390

  De Bruijn, Reneé F A G ^a,b   Direk, Nese ^a   Mirza, Saira Saeed ^a   Hofman, Albert ^a   Koudstaal, Peter J ^a   Tiemeier, Henning ^a   Ikram, M Arfan ^a,b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Netherlands Centre for Healthy Aging   (Netherlands)

Author keywords

anxiety disorders; anxiety symptoms; cognition; dementia; Epidemiology

Indexed keywords

APOLIPOPROTEIN E4;

AGED; AGORAPHOBIA; ALZHEIMER DISEASE; ANXIETY DISORDER; ARTICLE; COGNITION; COGNITION ASSESSMENT; COGNITIVE DEFECT; COHORT ANALYSIS; DEMENTIA; DEPRESSION; DISEASE ASSOCIATION; DSM-IV; EDUCATIONAL STATUS; FEMALE; FOLLOW UP; GENERALIZED ANXIETY DISORDER; HETEROZYGOTE; HOSPITAL ANXIETY AND DEPRESSION SCALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; PANIC; POPULATION RESEARCH; PROSPECTIVE STUDY; RISK ASSESSMENT; SOCIAL PHOBIA; ANXIETY; ANXIETY DISORDERS; COGNITION DISORDERS; MIDDLE AGED; RISK; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANXIETY; ANXIETY DISORDERS; COGNITION DISORDERS; DEMENTIA; FEMALE; HUMANS; MALE; MIDDLE AGED; NETHERLANDS; PROSPECTIVE STUDIES; RISK;

EID: 84928214512     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1016/j.jagp.2014.03.001     Document Type: Article

References (46)

1. Lyketsos CG, Carrillo MC, Ryan JM, et al: Neuropsychiatric symptoms in Alzheimer's disease. Alzheim Dement 2011; 7:532-539
2. Diefenbach GJ, Bragdon LB, Blank K: Geriatric anxiety inventory: factor structure and associations with cognitive status. Am J Geriatr Psychiatry 2014; 22:1418-1426
3. Murray TM, Sachs GA, Stocking C, et al: The symptom experience of community-dwelling persons with dementia: self and caregiver report and comparison with standardized symptom assessment measures. Am J Geriatr Psychiatry 2012; 20:298-305
4. Spalletta G, Musicco M, Padovani A, et al: Neuropsychiatric symptoms and syndromes in a large cohort of newly diagnosed, untreated patients with Alzheimer disease. Am J Geriatr Psychiatry 2010; 18:1026-1035
5. Saczynski JS, Beiser A, Seshadri S, et al: Depressive symptoms and risk of dementia: the Framingham Heart Study. Neurology 2010; 75:35-41
6. Devanand DP, Sano M, Tang MX, et al: Depressed mood and the incidence of Alzheimer's disease in the elderly living in the community. Arch Gen Psychiatry 1996; 53:175-182
7. Beaudreau SA, O'Hara R: Late-life anxiety and cognitive impairment: a review. Am J Geriatr Psychiatry 2008; 16:790-803
8. Gallacher J, Bayer A, Fish M, et al: Does anxiety affect risk of dementia? Findings from the Caerphilly Prospective Study. Psychosom Med 2009; 71:659-666
9. Sinoff G, Werner P: Anxiety disorder and accompanying subjective memory loss in the elderly as a predictor of future cognitive decline. Int J Geriatr Psychiatry 2003; 18:951-959
10. Wilson RS, Begeny CT, Boyle PA, et al: Vulnerability to stress, anxiety, and development of dementia in old age. Am J Geriatr Psychiatry 2011; 19:327-334
11. Burton C, Campbell P, Jordan K, et al: The association of anxiety and depression with future dementia diagnosis: a case-control study in primary care. Fam Pract 2013; 30:25-30
12. Gallagher D, Coen R, Kilroy D, et al: Anxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment. Int J Geriatr Psychiatry 2011; 26:166-172
13. Palmer K, Berger AK, Monastero R, et al: Predictors of progression from mild cognitive impairment to Alzheimer disease. Neurology 2007; 68:1596-1602
14. Potvin O, Forget H, Grenier S, et al: Anxiety, depression, and 1-year incident cognitive impairment in community-dwelling older adults. J Am Geriatr Soc 2011; 59:1421-1428
15. Pietrzak RH, Maruff P, Woodward M, et al: Mild worry symptoms predict decline in learning and memory in healthy older adults: a 2-year prospective cohort study. Am J Geriatr Psychiatry 2012; 20:266-275
16. Ramakers IH, Visser PJ, Aalten P, et al: Affective symptoms as predictors of Alzheimer's disease in subjects with mild cognitive impairment: a 10-year follow-up study. Psychol Med 2010; 40: 1193-1201
17. Devier DJ, Pelton GH, Tabert MH, et al: The impact of anxiety on conversion from mild cognitive impairment to Alzheimer's disease. Int J Geriatr Psychiatry 2009; 24:1335-1342
18. Chan WC, Lam LC, Tam CW, et al: Neuropsychiatric symptoms are associated with increased risks of progression to dementia: a 2-year prospective study of 321 Chinese older persons with mild cognitive impairment. Age Ageing 2011; 40:30-35
19. Potvin O, Hudon C, Forget H, et al: Prevalence of psychiatric disorders in community-dwelling older men and women with cognitive impairment no dementia: results from the ESA study. Aging Ment Health 2012; 16:218-227
20. Bunce D, Batterham PJ, Mackinnon AJ, et al: Depression, anxiety and cognition in community-dwelling adults aged 70 years and over. J Psychiatr Res 2012; 46:1662-1666
21. Potvin O, Bergua V, Meillon C, et al: State anxiety and cognitive functioning in older adults. Am J Geriatr Psychiatry 2013; 21: 915-924
22. Andreescu C, Teverovsky E, Fu B, et al: Old worries and new anxieties: behavioral symptoms and mild cognitive impairment in a population study. Am J Geriatr Psychiatry 2014; 22:274-284
23. Okereke OI, Grodstein F: Phobic anxiety and cognitive performance over 4 years among community-dwelling older women in the nurses' health study. Am J Geriatr Psychiatry 2013; 21: 1125-1134
24. Hofman A, Darwish Murad S, van Duijn CM, et al: The Rotterdam Study: 2014 objectives and design update. Eur J Epidemiol 2013; 28:889-926
25. Zigmond AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67:361-370
26. Wittchen HU, Lachner G, Wunderlich U, et al: Test-retest reliability of the computerized DSM-IV version of the Munich-Composite International Diagnostic Interview (M-CIDI). Soc Psychiatry Psychiatr Epidemiol 1998; 33:568-578
27. American Psychiatric Association: Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC, American Psychiatric Association, 1994
28. Folstein MF, Folstein SE, McHugh PR: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198
29. Copeland JR, Kelleher MJ, Kellett JM, et al: A semi-structured clinical interview for the assessment of diagnosis and mental state in the elderly: the Geriatric Mental State Schedule. I. Development and reliability. Psychol Med 1976; 6:439-449
30. Roth M, Tym E, Mountjoy CQ, et al: CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br J Psychiatry 1986; 149:698-709
31. American Psychiatric Association: Diagnostic and statistical manual of mental disorders. 3rd ed., revised. Washington, DC, American Psychiatric Association, 1987
32. McKhann G, Drachman D, Folstein M, et al: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34:939-944
33. Lezak MD: Neuropsychological assessment. 4th ed. New York, Oxford University Press, 2004
34. Golden CJ: Identification of brain disorders by the Stroop Color and Word Test. J Clin Psychol 1976; 32:654-658
35. Welsh KA, Butters N, Mohs RC, et al: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological battery. Neurology 1994; 44: 609-614
36. Brand N, Jolles J: Learning and retrieval rate of words presented auditorily and visually. J Gen Psychol 1985; 112:201-210
37. Prins ND, van Dijk EJ, den Heijer T, et al: Cerebral small-vessel disease and decline in information processing speed, executive function and memory. Brain 2005; 128:2034-2041
38. Luijendijk HJ, van den Berg JF, Dekker MJ, et al: Incidence and recurrence of late-life depression. Arch Gen Psychiatry 2008; 65: 1394-1401
39. Radloff LS: The CES-D scale: a self-report depression scale for research in the general population. Appl Psych Meas 1977; 1: 385-401
40. Wing JK, Babor T, Brugha T, et al: SCAN. Schedules for clinical assessment in neuropsychiatry. Arch Gen Psychiatry 1990; 47: 589-593
41. American Psychiatric Association: Diagnostic and statistical manual of mental disorders. 4th ed., revised. Washington, DC, American Psychiatric Association, 2000
42. Wenham PR, Price WH, Blandell G: Apolipoprotein E genotyping by one-stage PCR. Lancet 1991; 337:1158-1159
43. Beaudreau SA, MacKay-Brandt A, Reynolds J: Application of a cognitive neuroscience perspective of cognitive control to latelife anxiety. J Anxiety Disord 2013; 27:559-566
44. Beaudreau SA, O'Hara R: The association of anxiety and depressive symptoms with cognitive performance in communitydwelling older adults. Psychol Aging 2009; 24:507-512
45. Yochim BP, Mueller AE, Segal DL: Late life anxiety is associated with decreased memory and executive functioning in community dwelling older adults. J Anxiety Disord 2013; 27:567-575
46. Ramakers IH, Verhey FR, Scheltens P, et al: Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment. Psychol Med 2013; 43:911-920