PNPLA3 I148M variant is associated with metabolic stress-response phenotype in patients with nonalcoholic fatty liver disease

Hepatology

Volumn 61, Issue 5, 2015, Pages 1769-1769

  Sookoian, Silvia ^a   Castaño, Gustavo O ^b   Pirola, Carlos J ^a  

^a INSTITUTO DE INVESTIGACIONES MÉDICAS ALFREDO LANARI   (Argentina)

^b Hospital General de Agudos Dr Abel Zubizarreta   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; PNPLA3 PROTEIN; UNCLASSIFIED DRUG; TRIACYLGLYCEROL LIPASE;

ANAEROBIC METABOLISM; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; LETTER; METABOLIC STRESS; METABOLISM; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATION REDUCTION STATE; PHENOTYPE; PRIORITY JOURNAL; RISK ASSESSMENT; ANIMAL; FATTY LIVER; FEMALE; GENETICS; MALE;

ANIMALS; FATTY LIVER; FEMALE; HUMANS; LIPASE; MALE; MEMBRANE PROTEINS;

EID: 84928207310     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27390     Document Type: Letter

References (4)

1. Smagris E, BasuRay S, Li J, Huang Y, Lai KM, Gromada J, et al. Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis. Hepatology 2015;61:108-118.
2. Min HK, Sookoian SC, Pirola CJ, Cheng J, Mirshahi F, Sanyal AJ. Metabolic profiling reveals that Pnpla3 induces widespread effects on metabolism beyond triacylglycerol remodeling In Huh-7 hepatoma cells. Am J Physiol Gastrointest Liver Physiol 2014 [Epub ahead of print].
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4. Hohorst HJ, Kreutz FH, Buecher T. On the metabolite content and the metabolite concentration in the liver of the rat. Biochem Z 1959;332:18-46.