Impact of training status on LPS-induced acute inflammation in humans

Journal of Applied Physiology

Volumn 118, Issue 7, 2015, Pages 818-829

  Olesen, J ^a   Bienso R S ^a   Meinertz, S ^a   Van Hauen, L ^a   Rasmussen, S M ^a   Gliemann, L ^a   Plomgaard, P ^a,b   Pilegaard, H ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

Author keywords

Acute inflammation; Exercise immunology; Skeletal muscle

Indexed keywords

CYTOKINE; LIPOPOLYSACCHARIDE;

CHEMICALLY INDUCED; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECTS; EXERCISE; FITNESS; HUMAN; IMMUNOLOGY; INFLAMMATION; MALE; PROCEDURES; SKELETAL MUSCLE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; YOUNG ADULT;

CYTOKINES; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MUSCLE, SKELETAL; PHYSICAL CONDITIONING, HUMAN; PHYSICAL FITNESS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; YOUNG ADULT;

EID: 84928178594     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00725.2014     Document Type: Article

References (42)

1. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 124: 783-801, 2006.
2. Andreasen AS, Kelly M, Berg RM, Moller K, Pedersen BK. Type 2 diabetes is associated with altered NF-kappaB DNA binding activity, JNK phosphorylation, and AMPK phosphorylation in skeletal muscle after LPS. PLoS One 6: e23999, 2011.
3. Andreasen AS, Pedersen-Skovsgaard T, Berg RM, Svendsen KD, Feldt-Rasmussen B, Pedersen BK, Moller K. Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia. Intensive Care Med 36: 1548-1555, 2010.
4. Bergstrom J. Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest 35: 609-616, 1975.
5. Bienso RS, Olesen J, van Hauen L, Meinertz S, Halling JF, Gliemann L, Plomgaard P, Pilegaard H. Exercise-induced AMPK and pyruvate dehydrogenase regulation is maintained during short-term low-grade inflammation. Pflügers Arch 467: 341-350, 2015.
6. Birk JB, Wojtaszewski JF. Predominant alpha2/beta2/gamma3 AMPK activation during exercise in human skeletal muscle. J Physiol 577: 1021-1032, 2006.
7. Boumpas DT, Chrousos GP, Wilder RL, Cupps TR, Balow JE. Glucocorticoid therapy for immune-mediated diseases: basic and clinical correlates. Ann Intern Med 119: 1198-1208, 1993.
8. Bruunsgaard H, Skinhoj P, Qvist J, Pedersen BK. Elderly humans show prolonged in vivo inflammatory activity during pneumococcal infections. J Infect Dis 180: 551-554, 1999.
9. Castellani L, Root-Mccaig J, Frendo-Cumbo S, Beaudoin MS, Wright DC. Exercise training protects against an acute inflammatory insult in mouse epididymal adipose tissue. J Appl Physiol (1985) 116: 1272-1280, 2014.
10. Chen HI, Hsieh SY, Yang FL, Hsu YH, Lin CC. Exercise training attenuates septic responses in conscious rats. Med Sci Sports Exerc 39: 435-442, 2007.
11. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
12. Eisenberger NI, Berkman ET, Inagaki TK, Rameson LT, Mashal NM, Irwin MR. Inflammation-induced anhedonia: endotoxin reduces ventral striatum responses to reward. Biol Psychiatry 68: 748-754, 2010.
13. Frellstedt L, Waldschmidt I, Gosset P, Desmet C, Pirottin D, Bureau F, Farnir F, Franck T, Dupuis-Tricaud MC, Lekeux P, Art T. Training modifies innate immune responses in blood monocytes and in pulmonary alveolar macrophages. Am J Respir Cell Mol Biol 51: 135-142, 2014.
14. Frost RA, Nystrom GJ, Lang CH. Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle. Am J Physiol Regul Integr Comp Physiol 283: R698-R709, 2002.
15. Geerlings SE, Brouwer EC, Van Kessel KC, Gaastra W, Stolk RP, Hoepelman AI. Cytokine secretion is impaired in women with diabetes mellitus. Eur J Clin Invest 30: 995-1001, 2000.
16. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91, 1993.
17. Kawanishi N, Yano H, Yokogawa Y, Suzuki K. Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice. Exerc Immunol Rev 16: 105-118, 2010.
18. Kitamura H, Shiva D, Woods JA, Yano H. Beta-adrenergic receptor blockade attenuates the exercise-induced suppression of TNF-alpha in response to lipopolysaccharide in rats. Neuroimmunomodulation 14: 91-96, 2007.
19. Kizaki T, Takemasa T, Sakurai T, Izawa T, Hanawa T, Kamiya S, Haga S, Imaizumi K, Ohno H. Adaptation of macrophages to exercise training improves innate immunity. Biochem Biophys Res Commun 372: 152-156, 2008.
20. Kohut ML, McCann DA, Russell DW, Konopka DN, Cunnick JE, Franke WD, Castillo MC, Reighard AE, Vanderah E. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun 20: 201-209, 2006.
21. Lundby C, Nordsborg N, Kusuhara K, Kristensen KM, Neufer PD, Pilegaard H. Gene expression in human skeletal muscle: alternative normalization method and effect of repeated biopsies. Eur J Appl Physiol 95: 351-360, 2005.
22. Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 22: 240-73, 2009.
23. Monastra G, Secchi EF. Beta-adrenergic receptors mediate in vivo the adrenaline inhibition of lipopolysaccharide-induced tumor necrosis factor release. Immunol Lett 38: 127-130, 1993.
24. Muller LM, Gorter KJ, Hak E, Goudzwaard WL, Schellevis FG, Hoepelman AI, Rutten GE. Increased risk of common infections in patients with type 1 and type 2 diabetes mellitus. Clin Infect Dis 41: 281-288, 2005.
25. Nicklas BJ, Hsu FC, Brinkley TJ, Church T, Goodpaster BH, Kritchevsky SB, Pahor M. Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc 56: 2045-2052, 2008.
26. Nieman DC. Exercise immunology: practical applications. Int J Sports Med 18, Suppl 1: S91-S100, 1997.
27. Olesen J, Larsson S, Iversen N, Yousafzai S, Hellsten Y, Pilegaard H. Skeletal muscle PGC-1alpha is required for maintaining an acute LPSinduced TNFalpha response. PLoS One 7: e32222, 2012.
28. Pedersen BK. The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control. Essays Biochem 42: 105-117, 2006.
29. Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 8: 457-465, 2012.
30. Pedersen BK, Toft AD. Effects of exercise on lymphocytes and cytokines. Br J Sports Med 34: 246-251, 2000.
31. Pilegaard H, Ordway GA, Saltin B, Neufer PD. Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am J Physiol Endocrinol Metab 279: E806-E814, 2000.
32. Severn A, Rapson NT, Hunter CA, Liew FY. Regulation of tumor necrosis factor production by adrenaline and beta-adrenergic agonists. J Immunol 148: 3441-3445, 1992.
33. Sewter CP, Digby JE, Blows F, Prins J, O'Rahilly S. Regulation of tumour necrosis factor-alpha release from human adipose tissue in vitro. J Endocrinol 163: 33-38, 1999.
34. Shah BR, Hux JE. Quantifying the risk of infectious diseases for people with diabetes. Diabetes Care 26: 510-513, 2003.
35. Sondergaard SR, Essen MV, Schjerling P, Ullum H, Pedersen BK. Proliferation and telomere length in acutely mobilized blood mononuclear cells in HIV infected patients. Clin Exp Immunol 127: 499-506, 2002.
36. Spoto B, Di BE, Mattace-Raso F, Sijbrands E, Vilardi A, Parlongo RM, Pizzini P, Pisano A, Vermi W, Testa A, Cutrupi S, D'Arrigo G, Lonardi S, Tripepi G, Cancarini G, Zoccali C. Pro- and anti-inflammatory cytokine gene expression in subcutaneous and visceral fat in severe obesity. Nutr Metab Cardiovasc Dis 24: 1137-1143, 2014.
37. Starkie R, Ostrowski SR, Jauffred S, Febbraio M, Pedersen BK. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB J 17: 884-886, 2003.
38. Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K. Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc Immunol Rev 8: 6-48, 2002.
39. Telzak EE, Greenberg MS, Budnick LD, Singh T, Blum S. Diabetes mellitus-a newly described risk factor for infection from Salmonella enteritidis. J Infect Dis 164: 538-541, 1991.
40. Vatier C, Kadiri S, Muscat A, Chapron C, Capeau J, Antoine B. Visceral and subcutaneous adipose tissue from lean women respond differently to lipopolysaccharide-induced alteration of inflammation and glyceroneogenesis. Nutr Diabetes 2: e51, 2012.
41. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808, 2003.
42. Woods JA, Wilund KR, Martin SA, Kistler BM. Exercise, inflammation and aging. Aging Dis 3: 130-140, 2012.