Drug loading optimization and extended drug delivery of corticoids from pHEMA based soft contact lenses hydrogels via chemical and microstructural modifications

International Journal of Pharmaceutics

Volumn 487, Issue 1-2, 2015, Pages 260-269

  García Millán, Eva ^a   Koprivnik, Sandra ^a   Otero Espinar, Francisco Javier ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Controlled drug release delivery; Hydrogels; Microstructure; Ophthalmic drug delivery; Poly(2 hydroxyethyl methacrylate); Therapeutic soft contact lenses; Triamcinolone acetonide

Indexed keywords

1 VINYL 2 PYRROLIDINONE; 2 HYDROXYETHYL METHACRYLATE; ETHYLENE GLYCOL DIMETHACRYLATE; METHACRYLIC ACID; MONOMER; TRIAMCINOLONE ACETONIDE; CORTICOSTEROID; CROSS LINKING REAGENT; HYDROGEL; METHACRYLIC ACID DERIVATIVE; POLYMACON; POVIDONE; WATER;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; HYDROGEL; IN VITRO STUDY; ISOTHERM; KINETICS; POLYMERIZATION; POROSITY; PRIORITY JOURNAL; SOFT CONTACT LENS; SYNTHESIS; WATER TRANSPORT; CHEMISTRY; DRUG FORMULATION; HYDROPHILIC CONTACT LENS; MEDICINAL CHEMISTRY; THERMODYNAMICS;

ADRENAL CORTEX HORMONES; CHEMISTRY, PHARMACEUTICAL; CONTACT LENSES, HYDROPHILIC; CROSS-LINKING REAGENTS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; HYDROGELS; KINETICS; METHACRYLATES; POLYHYDROXYETHYL METHACRYLATE; POROSITY; POVIDONE; THERMODYNAMICS; TRIAMCINOLONE ACETONIDE; WATER;

EID: 84928158524     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.04.037     Document Type: Article

References (21)

1. A.A. Alencar de Queiroz, A. Gallardo, and J. San Román Vinylpyrrolidone-N,N′-dimethylacrylamide water-soluble copolymers: synthesis, physical-chemical properties and proteic interactions Biomaterials 21 2000 1631 1643
2. C. Alvarez-Lorenzo, H. Hiratani, J.L. Gómez-Amoza, R. Martínez-Pacheco, C. Souto, and A. Concheiro Soft contact lenses capable of sustained delivery of timolol J. Pharm. Sci. 91 2002 2182 2192
3. C. Alvarez-Lorenzo, F. Yañez, R. Barreiro-Iglesias, and A. Concheiro Imprinted soft contact lenses as norfloxacin delivery systems J. Control. Release 113 2006 236 244
4. M.T. Am Ende, and N.A. Peppas Transport of ionizable drugs and proteins in crosslinked poly(acrylic acid) and poly(acrylic acid-co-2-hydroxyethyl methacrylate) hydrogels. II. Diffusion and release studies J. Control. Release 48 1997 47 56
5. P. Andrade-Vivero, E. Fernandez-Gabriel, C. Alvarez-Lorenzo, and A. Concheiro Improving the loading and release of NSAIDs from pHEMA hydrogels by copolymerization with functionalized monomers J. Pharm. Sci. 96 2007 802 813
6. S. Couch, and S. Bakri Intravitreal triamcinolone for intraocular inflammation and associates macular edema Clin. Ophthalmol. 3 2009 79 86
7. C.H. Giles, D. Smith, and A. Huitson A general treatment and classification of the solute adsorption isotherm. I. Theoretical J. Colloid Interface Sci. 47 1974 755 765
8. D. Gulsen, and A. Chauhan Ophthalmic drug delivery through contact lenses Invest. Ophthalmol. Vis. Sci. 45 2004 2342 2347
9. M.A. Iannuzzia, R. Reber III, D.M. Lentza, J. Zhaob, L. Mab, and R.C. Hedden USANS study of porosity and water content in sponge-like hydrogels Polymer 51 2010 2049 2056
10. C.M. Jermak, J.T. Dellacroce, J. Heffez, and G.A. Peyman Triamcinolone acetonide in ocular therapeutics Surv. Ophthalmol. 52 2007 503 522
11. J. Kim, and A. Chauhan Dexamethasone transport and ocular delivery from poly(hydroxyethyl methacrylate) gels Int. J. Pharm. 353 2008 205 222
12. J.C. Lang Ocular drug delivery conventional ocular formulations Adv. Drug Deliv. Rev. 16 1995 39 43
13. Q. Liu, E.L. Hedberg, Z. Liu, R. Bahulekar, R.K. Meszlenyi, and A.G. Mikos Preparation of macroporous poly(2-hydroxyethyl methacrylate) hydrogels by enhanced phase separation Biomaterials 21 2000 2163 2169
14. M.D. Lloid Intraocular steroids for cystoid macular edema Adv. Ocular Care 2010 36 38
15. A. Ludwig The use of mucoadhesive polymers in ocular drug delivery Adv. Drug Deliv. Rev. 57 2005 1595 1639
16. S. Mansoor, B.D. Kuppermann, and M.C. Kenney Intraocular sustained release delivery systems for triamcinolone acetonide Pharm. Res. 26 2009 770 784
17. J.F. Rosa dos Santos, R. Couceiro, A. Concheiro, J.-J. Torres-Labandeira, and C. Alvarez-Lorenzo Poly(hydroxyethyl methacrylate-co-methacrylated-β-cyclodextrin) hydrogels: synthesis, cytocompatibility, mechanical properties and drug loading/release properties Acta Biomater. 4 2008 745 755
18. T. Sato, R. Uchida, H. Tanigawa, K. Uno, and A. Murakami Application of polymer gels containing side-chain phosphate groups to drug-delivery contact lenses J. Appl. Polym. Sci. 98 2005 731 735
19. J. Siepmann, and N.A. Peppas Higuchi equation: derivation applications, use and misuse Int. J. Pharm. 418 2011 6 12
20. E. Voudrias, K. Fytianos, and E. Bozani Sorption-desorption isotherms of dyes from aqueous solutions and wastewaters with different sorbent materials Global Nest Int. J. 4 2002 75 83
21. F. Yañez, J.L. Gomez-Amoza, B. Magariños, A. Concheiro, and C. Alvarez-Lorenzo Hydrogels porosity and bacteria penetration: where is the pore size threshold? J Membr. Sci. 365 2010 248 255