Routine iron supplementation and screening for iron deficiency anemia in pregnancy: A systematic review for the U.S. preventive services task force

Annals of Internal Medicine

Volumn 162, Issue 8, 2015, Pages 566-576

  Cantor, Amy G ^a   Bougatsos, Christina ^a   Dana, Tracy ^a   Blazina, Ian ^a   McDonagh, Marian ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON;

APGAR SCORE; CESAREAN SECTION; CLINICAL PRACTICE; CONTROLLED CLINICAL TRIAL (TOPIC); FOLLOW UP; GESTATIONAL AGE; HUMAN; INCIDENCE; INFANT MORTALITY; IRON DEFICIENCY ANEMIA; IRON THERAPY; LOW BIRTH WEIGHT; META ANALYSIS; PERINATAL MORTALITY; PREGNANCY DISORDER; PREGNANCY OUTCOME; PREGNANT WOMAN; PREMATURE LABOR; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; TREATMENT OUTCOME; ADVERSE EFFECTS; ANEMIA, IRON-DEFICIENCY; ASYMPTOMATIC DISEASE; BLOOD EXAMINATION; DIET SUPPLEMENTATION; FEMALE; MASS SCREENING; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC;

ANEMIA, IRON-DEFICIENCY; ASYMPTOMATIC DISEASES; DIETARY SUPPLEMENTS; FEMALE; HEMATOLOGIC TESTS; HUMANS; IRON; MASS SCREENING; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PREGNANCY OUTCOME;

EID: 84928155737     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/M14-2932     Document Type: Review

References (42)

1. Recommendations to prevent and control iron deficiency in the United States. Centers for Disease Control and Prevention. MMWR Recomm Rep. 1998;47:1-29. [PMID: 9563847]
2. Earl R, Woteki CE, eds. Iron Deficiency Anemia: Recommended Guidelines for the Prevention, Detection, and Management Among U. S. Children and Women of Childbearing Age. Washington, DC: National Academies Pr; 1993.
3. Krishnamurti L. Part 9: Iron-deficiency anemia. In: McInerny TK, Adam HM, Campbell DE, Kamat DM, Kelleher KJ, eds. American Academy of Pediatrics Textbook of Pediatric Care. Elk Grove Village, IL: American Academy of Pediatrics; 2009.
4. Scholl TO. Iron status during pregnancy: setting the stage for mother and infant. Am J Clin Nutr. 2005;81:1218S-1222S. [PMID: 15883455]
5. Mei Z, Cogswell ME, Looker AC, Pfeiffer CM, Cusick SE, Lacher DA, et al. Assessment of iron status in US pregnant women from the National Health and Nutrition Examination Survey (NHANES), 1999-2006. Am J Clin Nutr. 2011;93:1312-20. [PMID: 21430118] doi: 10.3945/ajcn. 110.007195
6. Griffin IJ, Abrams SA. Iron and breastfeeding. Pediatr Clin North Am. 2001;48:401-13. [PMID: 11339160]
7. World Health Organization. Iron Deficiency Anaemia: Assessment, Prevention and Control. A Guide for Programme Managers. Geneva: World Health Organization; 2001. Accessed at www.who.int/nutrition/publications/en/ida-assessment-prevention-control.pdf on 6 February 2015.
8. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 95: anemia in pregnancy. Obstet Gynecol. 2008;112:201-7. [PMID: 18591330] doi:10.1097/AOG.0b013e 3181809c0d
9. Hoffman R, Benz EJ, Silberstein LE, Heslop H, Weitz J, Anastasi J. Hematology: Basic Principles and Practice. 6th ed. Philadelphia: Elsevier Saunders; 2012.
10. Bothwell TH. Iron requirements in pregnancy and strategies to meet them. Am J Clin Nutr. 2000;72:257S-264S. [PMID: 10871591]
11. Pea-Rosas JP, De-Regil LM, Dowswell T, Viteri FE. Intermittent oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2012;7:CD009997. [PMID: 22786531] doi:10.1002/14651858. CD009997
12. World Health Organization. Iron and Folate Supplementation. Standards for Maternal and Neonatal Care. Integrated Management of Pregnancy and Childbirth (IMPAC). Volume 1.8. Geneva: World Health Organization; 2006.
13. Scholl TO, Hediger ML, Fischer RL, Shearer JW. Anemia vs iron deficiency: increased risk of preterm delivery in a prospective study. Am J Clin Nutr. 1992;55:985-8. [PMID: 1570808]
14. Murphy JF, O'Riordan J, Newcombe RG, Coles EC, Pearson JF. Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet. 1986;1:992-5. [PMID: 2871331]
15. Zhou LM, Yang WW, Hua JZ, Deng CQ, Tao X, Stoltzfus RJ. Relation of hemoglobin measured at different times in pregnancy to preterm birth and low birth weight in Shanghai, China. Am J Epidemiol. 1998;148:998-1006. [PMID: 9829872]
16. Klebanoff MA, Shiono PH, Selby JV, Trachtenberg AI, Graubard BI. Anemia and spontaneous preterm birth. Am J Obstet Gynecol. 1991;164:59-63. [PMID: 1986627]
17. Lu ZM, Goldenberg RL, Cliver SP, Cutter G, Blankson M. The relationship between maternal hematocrit and pregnancy outcome. Obstet Gynecol. 1991;77:190-4. [PMID: 1988879]
18. Singh K, Fong YF, Arulkumaran S. Anaemia in pregnancy-a cross-sectional study in Singapore. Eur J Clin Nutr. 1998;52:65-70. [PMID: 9481535]
19. U. S. Preventive Services Task Force. Recommendation statement: screening for iron deficiency anemia-including iron supplementation for children and pregnant women. Rockville, MD: U. S. Preventive Services Task Force; 2006. Accessed at www.uspreventiveservicestaskforce.org/uspstf06/ironsc/ironscr.pdf on 6 February 2015.
20. McDonagh M, Cantor A, Bougatsos C, Dana T, Blazina I. Routine iron supplementation and screening for iron deficiency anemia in pregnant women: a systematic review to update the U. S. Preventive Services Task Force recommendation. Evidence synthesis no. 123. AHRQ publication no. 13-05188-EF-1. Rockville, MD: Agency for Healthcare Research and Quality; 2015.
21. Di Guiseppi C, ed. Screening for Iron Deficiency Anemia-Including Iron Prophylaxis. Guide to Clinical Preventive Services: Report of the U. S. Preventive Services Task Force. 2nd ed. Baltimore: Williams & Wilkins; 1996.
22. Oregon Evidence-based Practice Center. Screening for iron deficiency anemia in childhood and pregnancy: update of the 1996 U. S. Preventive Services Task Force review. Evidence synthesis no.
23. AHRQ publication no. 06-0590-EF-1. Rockville, MD: Agency for Healthcare Research and Quality; 2006. Accessed at www.uspreventiveservicestaskforce.org/uspstf06/ironsc/ironscrev.pdf on 6 February 2015.
24. U. S. Preventive Services Task Force. Procedure Manual. AHRQ publication no. 08-05118-EF. Rockville, MD: Agency for Healthcare Research and Quality; 2008. Accessed at www.uspreventiveservices taskforce.org/uspstf08/methods/procmanual.htm on 6 February 2015.
25. United Nations Development Programme. Human Development Index (HDI)-2012 Rankings. United Nations Development Programme; 2014. Accessed at http://hdr.undp.org/en/statistics on 6 February 2015.
26. Makrides M, Crowther CA, Gibson RA, Gibson RS, Skeaff CM. Efficacy and tolerability of low-dose iron supplements during pregnancy: a randomized controlled trial. Am J Clin Nutr. 2003;78:145-53. [PMID: 12816784]
27. Ziaei S, Mehrnia M, Faghihzadeh S. Iron status markers in nonanemic pregnant women with and without iron supplementation. Int J Gynaecol Obstet. 2008;100:130-2. [PMID: 17977537]
28. Ziaei S, Norrozi M, Faghihzadeh S, Jafarbegloo E. A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin > or = 13.2 g/dL. BJOG. 2007;114:684-8. [PMID: 17516958]
29. Chan KK, Chan BC, Lam KF, Tam S, Lao TT. Iron supplement in pregnancy and development of gestational diabetes-a randomised placebo-controlled trial. BJOG. 2009;116:789-97. [PMID: 19432567] doi:10.1111/j.1471-0528.2008.02014.x
30. Cogswell ME, Parvanta I, Ickes L, Yip R, Brittenham GM. Iron supplementation during pregnancy, anemia, and birth weight: a randomized controlled trial. Am J Clin Nutr. 2003;78:773-81. [PMID: 14522736]
31. Falahi E, Akbari S, Ebrahimzade F, Gargari BP. Impact of prophylactic iron supplementation in healthy pregnant women on maternal iron status and birth outcome. Food Nutr Bull. 2011;32:213-7. [PMID: 22073795]
32. Meier PR, Nickerson HJ, Olson KA, Berg RL, Meyer JA. Prevention of iron deficiency anemia in adolescent and adult pregnancies. Clin Med Res. 2003;1:29-36. [PMID: 15931282]
33. Siega-Riz AM, Hartzema AG, Turnbull C, Thorp J, McDonald T, Cogswell ME. The effects of prophylactic iron given in prenatal supplements on iron status and birth outcomes: a randomized controlled trial. Am J Obstet Gynecol. 2006;194:512-9. [PMID: 16458655]
34. Eskeland B, Malterud K, Ulvik RJ, Hunskaar S. Iron supplementation in pregnancy: is less enough? A randomized, placebo controlled trial of low dose iron supplementation with and without heme iron. Acta Obstet Gynecol Scand. 1997;76:822-8. [PMID: 9351406]
35. Milman N, Agger AO, Nielsen OJ. Iron status markers and serum erythropoietin in 120 mothers and newborn infants. Effect of iron supplementation in normal pregnancy. Acta Obstet Gynecol Scand. 1994;73:200-4. [PMID: 8122498]
36. Barton DP, Joy MT, Lappin TR, Afrasiabi M, Morel JG, O'Riordan J, et al. Maternal erythropoietin in singleton pregnancies: a randomized trial on the effect of oral hematinic supplementation. Am J Obstet Gynecol. 1994;170:896-901. [PMID: 8141223]
37. Romslo I, Haram K, Sagen N, Augensen K. Iron requirement in normal pregnancy as assessed by serum ferritin, serum transferrin saturation and erythrocyte protoporphyrin determinations. Br J Obstet Gynaecol. 1983;90:101-7. [PMID: 6824608]
38. Zhou SJ, Gibson RA, Makrides M. Routine iron supplementation in pregnancy has no effect on iron status of children at six months and four years of age. J Pediatr. 2007;151:438-40. [PMID: 17889086]
39. Milman N, Agger AO, Nielsen OJ. Iron supplementation during pregnancy. Effect on iron status markers, serum erythropoietin and human placental lactogen. A placebo controlled study in 207 Danish women. Dan Med Bull. 1991;38:471-6. [PMID: 1802636]
40. Pea-Rosas JP, Viteri FE. Effects and safety of preventive oral iron or iron+folic acid supplementation for women during pregnancy. Cochrane Database Syst Rev. 2009:CD004736. [PMID: 19821332] doi:10.1002/14651858. CD004736.pub3
41. Reveiz L, Gyte GM, Cuervo LG, Casasbuenas A. Treatments for iron-deficiency anaemia in pregnancy. Cochrane Database Syst Rev. 2011:CD003094. [PMID: 21975735] doi:10.1002/14651858. CD003094.pub3
42. Cuervo LG, Mahomed K. Treatments for iron deficiency anaemia in pregnancy. Cochrane Database Syst Rev. 2001:CD003094. [PMID: 11406073]