Efficacy and tolerability of low-dose iron supplements during pregnancy: A randomized controlled trial

American Journal of Clinical Nutrition

Volumn 78, Issue 1, 2003, Pages 145-153

  Makrides, Maria ^a,b   Crowther, Caroline A ^b   Gibson, Robert A ^c,d   Gibson, Rosalind S ^e   Skeaff, C Murray ^e  

^a WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c Child Health Research Institute   (Australia)

^d FLINDERS MEDICAL CENTRE   (Australia)

^e UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Iron; Iron deficiency; Pregnancy; Randomized controlled trial

Indexed keywords

FERROUS SULFATE; IRON; ZINC;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON THERAPY; PREGNANCY; RANDOMIZED CONTROLLED TRIAL; ADULT; BLOOD; DOSE RESPONSE; HEALTH STATUS; INCIDENCE; IRON INTAKE; MATERNAL NUTRITION; NUTRITIONAL DEFICIENCY; PATIENT COMPLIANCE; PHYSIOLOGY; PREGNANCY COMPLICATION; PREGNANCY OUTCOME; TREATMENT OUTCOME;

ADULT; ANEMIA, IRON-DEFICIENCY; DEFICIENCY DISEASES; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HEALTH STATUS; HUMANS; INCIDENCE; IRON; IRON, DIETARY; PATIENT COMPLIANCE; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; PRENATAL NUTRITION PHYSIOLOGY; TREATMENT OUTCOME; ZINC;

EID: 0038168717     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/78.1.145     Document Type: Article

References (34)

1. Aggett P. Iron and women in the reproductive years. In: The British Nutrition Foundation's Task Force, ed. Iron: nutritional and physiological significance. 1st ed. London: Chapman and Hall, 1995: 110-8.
2. Subcommittee on Nutritional Status and Weight Gain During Pregnancy, Subcommittee on Dietary Intake and Nutrient Supplements During Pregnancy, Committee on Nutritional Status During Pregnancy and Lactation, Food and Nutrition Board, Institute of Medicine, National Academy of Sciences. Iron nutrition during pregnancy. In: Nutrition and Pregnancy: part I, weight gain, and part II, nutrient supplements. 1st ed. Washington, DC: National Academy Press, 1990:272-98.
3. Chan A, Scott J, McCaul K, Keane R. Pregnancy outcome in South Australia 1997. Adelaide, Australia: South Australian Health Commission, 1998.
4. Mahomed K. Iron supplementation in pregnancy (Cochrane Review). In: The Cochrane Library. Issue 4, Oxford, United Kingdom: Update Software, 2001.
5. Yip R, Dallman PR. Iron. In: Ziegler EE, ed. Present knowledge in nutrition. 7th ed. Washington, DC: ILSI Press, 1996:277-92.
6. US Preventive Services Task Force. Routine iron supplementation during pregnancy. JAMA 1993;270:2848-54.
7. Hallberg L, Ryttinger L, Solvell L. Side-effects of oral iron therapy. A double-blind study of different iron compounds in tablet form. Acta Med Scand Suppl 1966;459:3-10.
8. Solvell L. Oral iron therapy-side effects. In: Hallberg L, Harwerth HG, Vannotti A, eds. Iron deficiency: pathogenesis, clinical aspects, therapy. 1st ed. London: Academic Press, 1970:573-83.
9. Solomons NW. Competitive interaction of iron and zinc in the diet: consequences for human nutrition. J Nutr 1986;116:927-35.
10. Litovitz TL, Holm KC, Clancy C, Schmitz BF, Clark LR, Oderda GM. 1992 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 1993;11:494-555.
11. Enkin M, Keirse MJNC, Renfrew M, Neilson J. Dietary modification in pregnancy In: Enkin E, ed. A guide to effective care in pregnancy and childbirth. 2nd ed. Oxford, United Kingdom: Oxford University Press, 1995:28-33.
12. National Health & Medical Research Council. Recommended dietary intakes for use in Australia, 1991. Canberra, Australia: Australian Government Publishing Service, 1991.
13. McLennan W, Podger A. National Nutrition Survey: nutrient intakes and physical measurements Australia 1995. Canberra, Australia: Australian Bureau of Statistics, 1998.
14. Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992;30:473-83.
15. Daniel A Power, privilege and prestige: occupations in Australia. 1st ed. Melbourne: Longman-Cheshire, 1983.
16. Centers for Disease Control. CDC criteria for anemia in children and childbearing-aged women. MMWR Morbid Mortal Weekly Rep 1989;38:400-4.
17. Smith JC Jr, Butrimovitz GP, Purdy WC. Direct measurement of zinc in plasma by atomic absorption spectroscopy. Clin Chem 1979;25:1487-91.
18. McHorney CA, Ware JE Jr, Rogers W, Raczek AE, Lu JF. The validity and relative precision of MOS short- and long-form health status scales and Dartmouth COOP charts. Results from the Medical Outcomes Study. Med Care 1992;30:MS253-65.
19. Schilling MJ, Makrides M. Validation of a checklist to assess iron intake of pregnant women. Proceedings of the 3rd Annual Congress of the Perinatal Society of Australia and New Zealand. Parramatta, Australia: Perinatal Society of Australia and New Zealand, 1999:251.
20. Australian Bureau of Statistics. 1995 National Health Survey: SF-36 population norms Australia. Canberra, Australia: Australian Bureau of Statistics, 1997. (ABS catalogue no. 4399.0.)
21. Jameson S. Zinc status in pregnancy: the effect of zinc therapy on perinatal mortality, prematurity, and placental ablation. Ann N Y Acad Sci 1993;678:178-92.
22. Pilch SM, Senti FR. Analysis of zinc data from the second National Health and Nutrition Examination Survey (NHANES II). J Nutr 1985;115:1393-7.
23. Chan A, Scott J, Nguyen AM, Keane R. Pregnancy outcome in South Australia 1999. Adelaide, Australia: Department of Human Services, 1999.
24. Eskeland B, Malterud KE, Ulvik RJ, Hunskaar S. Iron supplementation in pregnancy: is less enough? A randomized, placebo controlled trial of low dose iron supplementation with and without heme iron. Acta Obstet Gynecol Scand 1997;76:822-8.
25. Chanarin I, Rothman D. Further observations on the relation between iron and folate status in pregnancy. Br Med J 1971;2:81-4.
26. Thomson JK, Prien-Larsen JC, Devantier A, Fogh-Andersen N. Low dose iron supplementation does not cover the need for iron during pregnancy. Acta Obstet Gynecol Scand 1993;72:93-8.
27. Taylor DJ, Mallen C, McDougall N, Lind T. Effect of iron supplementation on serum ferritin levels during and after pregnancy. Br J Obstet Gynaecol 1982;89:1011-7.
28. Milman N, Agger AO, Nielsen OJ. Iron supplementation during pregnancy. Effect on iron status markers, serum erythropoietin and human placental lactogen. A placebo controlled study in 207 Danish women. Dan Med Bull 1991;38:471-6.
29. Puolakka J, Janne O, Pakarinen A, Jarvinen PA, Vihko R. Serum ferritin as a measure of iron stores during and after normal pregnancy with and without iron supplements. Acta Obstet Gynecol Scand Suppl 1980;95:43-51.
30. Preziosi P, Prual A, Galan P, Daouda H, Boureima H, Hercberg S. Effect of iron supplementation on the iron status of pregnant women: consequences for newborns. Am J Clin Nutr 1997;66:1178-82.
31. Hambidge KM, Krebs NF, Sibley L, English J. Acute effects of iron therapy on zinc status during pregnancy. Obstet Gynecol 1987;70:593-6.
32. Stoltzfus RJ. Iron-deficiency anemia: reexamining the nature and magnitude of the public health problem. Summary: implications for research and programs. J Nutr 2001;131:697S-700S.
33. Hemminki E, Rimpela U. A randomized comparison of routine versus selective iron supplementation during pregnancy. J Am Coll Nutr 1991;10:3-10.
34. Schofield C, Stewart J, Wheeler E The diets of pregnant and post-pregnant women in different social groups in London and Edinburgh: calcium, iron, retinol, ascorbic acid and folic acid. Br J Nutr 1989;62:363-77.