Nephroblastoma overexpressed gene (NOV) enhances RCC cell motility through upregulation of ICAM-1 and COX-2 expression via Akt pathway

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 2, 2015, Pages 1302-1311

  Liu, Shuai ^a   Han, Liping ^b   Wang, Xiaoqing ^c   Liu, Zheng ^a   Ding, Sentai ^a   Lu, Jiaju ^a   Bi, Dongbin ^a   Mei, Yikun ^d   Niu, Zhihong ^a  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^c SHANDONG UNIVERSITY   (China)

^d SICHUAN UNIVERSITY   (China)

Author keywords

Akt pathway; Cell motility; COX 2; ICAM 1; NOV; Renal cell carcinoma

Indexed keywords

CYCLOOXYGENASE 2; INTERCELLULAR ADHESION MOLECULE 1; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; NOV PROTEIN, HUMAN; PROTEIN KINASE B;

CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KIDNEY CARCINOMA; KIDNEY TUMOR; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; UPREGULATION;

CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL MOVEMENT; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY NEOPLASMS; NEPHROBLASTOMA OVEREXPRESSED PROTEIN; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84928154826     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Ek ET and Choong PF. The role of high-dose therapy and autologous stem cell transplantation for pediatric bone and soft tissue sarcomas. Expert Rev Anticancer Ther 2006; 6: 225-37.
2. Caswell PT, Vadrevu S and Norman JC. Integrins: masters and slaves of endocytic transport. Nat Rev Mol Cell Biol 2009; 10: 843-53.
3. Tsuji T, Ibaragi S and Hu GF. Epithelial-mesenchymal transition and cell cooperativity in metastasis. Cancer Res 2009; 69: 7135-9.
4. Turini ME and DuBois RN. Cyclooxygenase-2: a therapeutic target. Annu Rev Med 2002; 53: 35-57.
5. Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Mukai S and Asai K. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res 1995; 55: 3785-9.
6. Hida T, Yatabe Y, Achiwa H, Muramatsu H, Kozaki K and Nakamura S. Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. Cancer Res 1998; 58: 3761-4.
7. Hwang D, Scollard D, Byrne J and Levine E. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J Natl Cancer Inst 1998; 90: 455-60.
8. Zimmerman T and Blanco FJ. Inhibitors targeting the LFA-1/ICAM-1 cell-adhesion interaction: Design and mechanism of action. Curr Pharm Des 2008; 14: 2128-2139.
9. Lawson C and Wolf S. ICAM-1 signaling in endothelial cells. Pharmacol Rep 2009; 61: 22-32.
10. Van de Stolpe A and van der Saag PT. Intercellular adhesion molecule-1. J Mol Med 1996; 74: 13-33.
11. Rosette C, Roth RB, Oeth P, Braun A, Kammerer S, Ekblom J and Denissenko MF. Role of ICAM1 in invasion of human breast cancer cells. Carcinogenesis 2005; 26: 943-950.
12. Grothey A, Heistermann P, Philippou S and Voigtmann R. Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with non-small-cell lung cancer: Correlation with histological expression of ICAM-1 and tumour stage. Br J Cancer 1998; 77: 801-807.
13. Rosette C, Roth RB, Oeth P, Braun A, Kammerer S, Ekblom J and Denissenko MF. Role of ICAM1 in invasion of human breast cancer cells. Carcinogenesis 2005; 26: 943-950.
14. Kleer CG, Zhang Y, Pan Q and Merajver SD. (CCN6) is a secreted tumor suppressor protein that modulates IGF signaling in inflammatory breast cancer. Neoplasia 2004; 6: 179-85.
15. Kleer CG, Zhang Y, Pan Q, van Golen KL, Wu ZF and Livant D. WISP3 is a novel tumor suppressor gene of inflammatory breast cancer. Oncogene 2002; 21: 3172-80.
16. Holbourn KP, Acharya KR and Perbal B. The CCN family of proteins: structure-function relationships. Trends Biochem Sci 2008; 33: 461-73.
17. Joliot V, Martinerie C, Dambrine G, Plassiart G, Brisac M and Crochet J. Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas. Mol Cell Biol 1992; 12: 10-21.
18. Chevalier G, Yeger H, Martinerie C, Laurent M, Alami J and Schofield PN. novH: differential expression in developing kidney and Wilm's tumors. Am J Pathol 1998; 152: 1563-75.
19. Yu C, Le AT, Yeger H, Perbal B and Alman BA. NOV (CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. J Pathol 2003; 201: 609-15.
20. Liu C, Liu XJ, Crowe PD, Kelner GS, Fan J and Barry G. Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation. Gene 1999; 238: 471-8.
21. Maillard M, Cadot B, Ball RY, Sethia K, Edwards DR and Perbal B. Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues. Mol Pathol 2001; 54: 275-80.
22. Tan TW, Yang WH, Lin YT, Hsu SF, Li TM and Kao ST. Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells. Carcinogenesis 2009; 30: 258-68.
23. Tan TW, Lai CH, Huang CY, Yang WH, Chen HT and Hsu HC. CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells. J Cell Biochem 2009; 107: 345-56.
24. Liu S, Liu Z, Bi DB, Yuan XD, Liu XW, Ding ST, Lu JJ and Niu ZH. CCN3 (NOV) regulates proliferation, adhesion, migration and invasion in clear cell renal cell carcinoma. Oncol Lett 2012; 35: 1099-1104.
25. Chuang JY, Yang WH, Chen HT, Huang CY, Tan TW and Lin YT. CCL5/CCR5 axis promotes the motility of human oral cancer cells. J Cell Physiol 2009; 220: 418-26.
26. Chiu YC, Lin CY, Chen CP, Huang KC, Tong KM and Tzeng CY. Peptidoglycan enhances IL-6 production in human synovial fibroblasts via TLR2 receptor,focal adhesion kinase, Akt, and AP-1- dependent pathway. J Immunol 2009; 183: 2785-92.
27. Yang SF, Chen MK, Hsieh YS, Chung TT, Hsieh YH and Lin CW. PGE2/EP1 signaling pathway enhances ICAM-1 expression and cell motility in oral cancer cells. J Biol Chem 2010; 285: 29808-29816.
28. Liu JF, Fong YC, Chang CS, Huang CY, Chen HT and Yang WH. Cyclooxygenase-2 enhances alpha2beta1 integrin expression and cell migration via EP1dependent signaling pathway in human chondrosarcoma cells. Mol Cancer 2010; 9: 43.
29. Duperray A, Languino LR, Plescia J, McDowall A, Hogg N, Craig AG, Berendt AR and Altieri DC. Molecular identification of a novel fibrinogen binding site on the first domain of ICAM-1 regulating leukocyte-endothelium bridging. J Biol Chem 1997; 272: 435-441.
30. Rauch BH, Muschenborn B, Braun M, Weber AA and Schror K. ICAM-1 and p38 MAPK mediate fibrinogen-induced migration of human vascular smooth muscle cells. Eur J Pharmacol 2007; 577: 54-57.
31. Roche Y, Pasquier D, Rambeaud JJ, Seigneurin D and Duperray A. Fibrinogen mediates bladder cancer cell migration in an ICAM-1-dependent pathway. Thromb Haemost 2003; 89: 1089-1097.
32. Huang WC, Chan ST, Yang TL, Tzeng CC and Chen CC. Inhibition of ICAM-1gene expression, monocyte adhesion and cancer cell invasion by targeting IKKcomplex: molecular and functional study of novel alpha-methylene-gammabutyrolactone derivatives. Carcinogenesis 2004; 25: 1925-1934.
33. Tang CH and Lu ME. Adiponectin increases motility of human prostate cancer cells via adipoR, p38, AMPK, and NF-kappaB pathways. Prostate 2009; 69: 1781-1789.