Myrtol ameliorates cartilage lesions in an osteoarthritis rat model

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 2, 2015, Pages 1435-1442

  Ying, Binbin ^a,b   Maimaiti, Abudu Kelimujiang ^c   Song, Donghui ^d   Zhu, Songsong ^a  

^a SICHUAN UNIVERSITY   (China)

^b NINGBO FIRST HOSPITAL   (China)

^c XINJIANG MEDICAL UNIVERSITY   (China)

^d NANTONG UNIVERSITY   (China)

Author keywords

Cytokines; Estradiol (E2); Glycosaminoglycan (GAG); Myrtol standardized; Osteoarthritis

Indexed keywords

CYTOKINE; DRUG COMBINATION; MYRTOL; TERPENE;

ANIMAL; ARTICULAR CARTILAGE; DISEASE MODEL; DRUG COMBINATION; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; METABOLISM; OSTEOARTHRITIS; PATHOLOGY; POLYMERASE CHAIN REACTION; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; CARTILAGE, ARTICULAR; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; IMMUNOHISTOCHEMISTRY; MONOTERPENES; OSTEOARTHRITIS; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84928152184     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Alexandersen P, Karsdal M, Byrjalsen I and Christiansen C. Strontium ranelate effect in postmenopausal women with different clinical levels of osteoarthritis. Climacteric 2011; 14: 236-243.
2. Marks R. Comorbid depression and anxiety impact hip osteoarthritis disability. Disabil Health J 2009; 2: 27-35.
3. Uhlig T, Slatkowsky-Christensen B, Moe RH and Kvien TK. The burden of osteoarthritis: the societal and the patient perspective. Therapy 2010; 7: 605-619.
4. Seed SM, Dunican KC and Lynch AM. Osteoarthritis: a review of treatment options. Geriatrics 2009; 64: 20-29.
5. Kalff KM, El Mouedden M, van Egmond J, Veening J, Joosten L, Scheffer GJ, Meert T and Vissers K. Pre-treatment with capsaicin in a rat osteoarthritis model reduces the symptoms of pain and bone damage induced by monosodium iodoacetate. Eur J Pharmacol 2010; 641: 108-113.
6. Trelle S, Reichenbach S, Wandel S, Hildebrand P, Tschannen B, Villiger PM, Egger M and Jüni P. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis. Br Med J 2011; 342: c7086.
7. Long L, Soeken K and Ernst E. Herbal medicines for the treatment of osteoarthritis: a systematic review. Rheumatology 2001; 40: 779-793.
8. Rantzsch U, Vacca G, Dück R and Gillissen A. Anti-inflammatory effects of myrtol standardized and other essential oils on alveolar macrophages from patients with chronic obstructive pulmonary disease. Eur J Med Res 2009; 14: 205-209.
9. Rantzsch U, Vacca G, Dück R and Gillissen A. Anti-inflammatory effects of myrtol standardized and other essential oils on alveolar macrophages from patients with chronic obstructive pulmonary disease. Eur J Med Res 2009; 14: 205-209.
10. Alem G, Mekonnen Y, Tiruneh M and Mulu A. Invitro antibacterial activity of crude preparation of myrtle (Myrtus communis) on common human pathogens. Ethiop Med J 2008; 46: 63-69.
11. Beuscher N, Kietzmann M, Bien E and Champeroux P. Interference of myrtol standardized with inflammatory and allergic mediators. Arzneimittelforschung 1998; 48: 985-989.
12. Anderson DD, Chubinskaya S, Guilak F, Martin JA, Oegema TR, Olson SA and Buckwalter JA. Post-traumatic osteoarthritis: Improved understanding and opportunities for early intervention. J Orthop Res 2011; 29: 802-809.
13. de Lange-Brokaar B, Ioan-Facsinay A, van Osch G, Zuurmond AM, Schoones J, Toes R, Huizinga T and Kloppenburg M. Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthritis Cartilage 2012; 20: 1484-1499.
14. Fernandes JC, Martel-Pelletier J and Pelletier JP. The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002; 39: 237-246.
15. Johnson E, Charchandi A, Babis G and Soucacos P. Apoptosis in osteoarthritis: morphology, mechanisms, and potential means for therapeutic intervention. J Surg Orthop 2008; 17: 147-152.
16. Lopez-Armada M, Carames B, Lires-Dean M, Cillero-Pastor B, Ruiz-Romero C, Galdo F and Blanco F. Cytokines, tumor necrosis factor-a and interleukin-1β, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes. Osteoarthritis Cartilage 2006; 14: 660-669.
17. Borzi RM, Mazzetti I, Magagnoli G, Paoletti S, Uguccioni M, Gatti R, Orlandini G, Cattini L and Facchini A. Growth-related oncogene a induction of apoptosis in osteoarthritis chondrocytes. Arthritis Rheum 2002; 46: 3201-3211.
18. Mankin HJ Dorfman H, Lippiello L, Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic humanhips: II. Correlation of morphology with biochemical and metabolicdata. J Bone Joint Surg Am 1971; 53: 523-537.
19. Sowers MR, McConnell D, Jannausch M, Buyuktur AG, Hochberg M and Jamadar DA. Estradiol and its metabolites and their association with knee osteoarthritis. Arthritis Rheum 2006; 54: 2481-2487.
20. Innes JF, Little CB, Hughes CE and Caterson B. Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early-and late-stage osteoarthritis. Am J Vet Res 2005; 66: 1679-1685.
21. Yamasaki K, Nakasa T, Miyaki S, Ishikawa M, Deie M, Adachi N, Yasunaga Y, Asahara H and Ochi M. Expression of microRNA-146a in osteoarthritis cartilage. Arthritis Rheum 2009; 60: 1035-1041.
22. van den Berg WB, Joosten LA, Kollias G and van de Loo FA. Role of tumour necrosis factor α in experimental arthritis: separate activity of interleukin 1β in chronicity and cartilage destruction. Ann Rheum Dis 1999; 58: I40-I48.
23. Webb GR, Westacott CI and Elson CJ. Chondrocyte tumor necrosis factor receptors and focal loss of cartilage in osteoarthritis. Osteoarthritis Cartilage 1997; 5: 427-437.
24. Juergens UR, Engelen T, Racké K, Stöber M, Gillissen A, Vetter H. Inhibitory activity of 1,8-cineol (eucalyptol) on cytokine production in human mononuclear phagocytes in vitro. Pulm Phamacol Therapeutics 2004; 17: 281-287.
25. Smith P, Shuler F, Georgescu H, Ghivizzani S, Johnstone B, Niyibizi C, Robbins P and Evans C. Genetic enhancement of matrix synthesis by articular chondrocytes: Comparison of different growth factor genes in the presence and absence of interleukin-1. Arthritis Rheum 2000; 43: 1156-1164.
26. Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage 2013; 21: 16-21.
27. Sui Y, Lee JH, DiMicco MA, Vanderploeg EJ, Blake SM, Hung HH, Plaas AH, James IE, Song XY and Lark MW. Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor α in immature bovine and adult human articular cartilage. Arthritis Rheum 2009; 60: 2985-2996.
28. Blanco FJ, Guitian R, Vázquez-Martul E, de Toro FJ and Galdo F. Osteoarthritis chondrocytes die by apoptosis: a possible pathway for osteoarthritis pathology. Arthritis Rheum 1998; 41: 284-289.
29. Kim D, Taylor H, Moore R, Paulsen D and Cho DY. Articular chondrocyte apoptosis in equine osteoarthritis. Vet J 2003; 166: 52-57.
30. Youle RJ and Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9: 47-59.
31. Oltval ZN, Milliman CL and Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death. Cell 1993; 74: 609-619.