Microbleeds in atypical presentations of Alzheimer's disease: A comparison to dementia of the Alzheimer's type

Journal of Alzheimer's Disease

Volumn 45, Issue 4, 2015, Pages 1109-1117

  Whitwell, Jennifer L ^a   Kantarci, Kejal ^a   Weigand, Stephen D ^a   Lundt, Emily S ^a   Gunter, Jeffrey L ^a   Duffy, Joseph R ^a   Strand, Edythe A ^a   Machulda, Mary M ^a   Spychalla, Anthony J ^a   Drubach, Daniel A ^a   Petersen, Ronald C ^a   Lowe, Val J ^a   Jack, Clifford R ^a   Josephs, Keith A ^a  

^a MAYO CLINIC   (United States)

Author keywords

Alzheimer's disease; amyloid ; dementia of the Alzheimer's type; early onset Alzheimer's disease; logopenic; magnetic resonance imaging; microbleeds; positron emission tomography; posterior cortical atrophy

Indexed keywords

AMYLOID BETA PROTEIN; PITTSBURGH COMPOUND B; 2-(4'-(METHYLAMINO)PHENYL)-6-HYDROXYBENZOTHIAZOLE; ANILINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; THIAZOLE DERIVATIVE;

AGE DISTRIBUTION; AGED; ALZHEIMER DISEASE; AMNESIA; ARTICLE; BLOOD FLOW; BRAIN HEMORRHAGE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DEMENTIA OF THE ALZHEIMER TYPE; DEMOGRAPHY; FEMALE; FRONTAL LOBE; HUMAN; HUMAN TISSUE; INTERRATER RELIABILITY; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NUCLEAR MAGNETIC RESONANCE; ONSET AGE; PET-CT SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; THREE DIMENSIONAL IMAGING; WHITE MATTER; BRAIN; COMPARATIVE STUDY; METABOLISM; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PHENOTYPE; SCINTISCANNING;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANILINE COMPOUNDS; BRAIN; CEREBRAL HEMORRHAGE; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; PHENOTYPE; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; THIAZOLES;

EID: 84928139396     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-142628     Document Type: Article

References (39)

1. Sperling RA, Jack CR Jr, Black SE, Frosch MP, Greenberg SM, Hyman BT, Scheltens P, Carrillo MC, Thies W, Bednar MM, Black RS, Brashear HR, Grundman M, Siemers ER, Feldman HH, Schindler RJ (2011) Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement 7, 367-385.
2. Schrag M, McAuleyG, Pomakian J, Jiffry A, Tung S, Mueller C, Vinters HV, Haacke EM, Holshouser B, Kido D, Kirsch WM (2010) Correlation of hypointensities in susceptibilityweighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: A postmortem MRI study. Acta Neuropathol 119, 291-302.
3. Cordonnier C, van der Flier WM (2011) Brain microbleeds and Alzheimer's disease: Innocent observation or key player? Brain 134, 335-344.
4. Goos JD, Kester MI, Barkhof F, Klein M, Blankenstein MA, Scheltens P, van der Flier WM (2009) Patients with Alzheimer disease with multiple microbleeds: Relation with cerebrospinal fluid biomarkers and cognition. Stroke 40, 3455-3460.
5. Pettersen JA, Sathiyamoorthy G, Gao FQ, Szilagyi G, Nadkarni NK, St George-Hyslop P, Rogaeva E, Black SE (2008) Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. Arch Neurol 65, 790-795.
6. Cordonnier C, van der Flier WM, Sluimer JD, Leys D, Barkhof F, Scheltens P (2006) Prevalence and severity of microbleeds in a memory clinic setting. Neurology 66, 1356-1360.
7. Nakata Y, Shiga K, Yoshikawa K, Mizuno T, Mori S, Yamada K, Nakajima K (2002) Subclinical brain hemorrhages in Alzheimer's disease: Evaluation by magnetic resonance T2∗-weighted images. Ann N Y Acad Sci 977, 169-172.
8. Hanyu H, Tanaka Y, Shimizu S, Takasaki M, Abe K (2003) Cerebral microbleeds in Alzheimer's disease. J Neurol 250, 1496-1497.
9. Nakata-Kudo Y, Mizuno T, Yamada K, Shiga K, Yoshikawa K, Mori S, Nishimura T, Nakajima K, Nakagawa M (2006) Microbleeds in Alzheimer disease are more related to cerebral amyloid angiopathy than cerebrovascular disease. Dement Geriatr Cogn Disord 22, 8-14.
10. Yates PA, Desmond PM, Phal PM, Steward C, Szoeke C, Salvado O, Ellis KA, Martins RN, Masters CL, Ames D,Villemagne VL, Rowe CC, GroupAR(2014) Incidence of cerebral microbleeds in preclinical Alzheimer disease. Neurology 82, 1266-1273.
11. Ryan NS, Bastos-Leite AJ, Rohrer JD, Werring DJ, Fox NC, Rossor MN, Schott JM (2012) Cerebral microbleeds in familial Alzheimer's disease. Brain 135, e201; author reply e202.
12. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDAWork Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
13. Kantarci K, Gunter JL, Tosakulwong N,Weigand SD, Senjem MS, Petersen RC, Aisen PS, Jagust WJ, Weiner MW, Jack CR Jr, Alzheimer's Disease Neuroimaging I (2013) Focal hemosiderin deposits and beta-amyloid load in the ADNI cohort. Alzheimers Dement 9(5 Suppl), S116-S123.
14. Greenberg SM, Eng JA, Ning M, Smith EE, Rosand J (2004) Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. Stroke 35, 1415-1420.
15. Werring DJ, Frazer DW, Coward LJ, Losseff NA, Watt H, Cipolotti L, Brown MM, Jager HR (2004) Cognitive dysfunction in patients with cerebral microbleeds on T2∗-weighted gradient-echo MRI. Brain 127, 2265-2275.
16. van der Vlies AE, Goos JD, Barkhof F, Scheltens P, van der Flier WM (2012) Microbleeds do not affect rate of cognitive decline in Alzheimer disease. Neurology 79, 763-769.
17. Whitwell JL, Dickson DW, Murray ME, Weigand SD, Tosakulwong N, Senjem ML, Knopman DS, Boeve BF, Parisi JE, Petersen RC, Jack CR Jr, Josephs KA (2012) Neuroimaging correlates of pathologically-defined atypical Alzheimer's disease. Lancet Neurol 11, 868-877.
18. Gorno-Tempini ML, Hillis AE, Weintraub S, Kertesz A, Mendez M, Cappa SF, Ogar JM, Rohrer JD, Black S, Boeve BF, Manes F, Dronkers NF, Vandenberghe R, Rascovsky K, Patterson K, Miller BL, Knopman DS, Hodges JR, Mesulam MM, Grossman M (2011) Classification of primary progressive aphasia and its variants. Neurology 76, 1006-1014.
19. Mesulam MM, Weintraub S, Rogalski EJ, Wieneke C, Geula C, Bigio EH (2014) Asymmetry and heterogeneity of Alzheimer's and frontotemporal pathology in primary progressive aphasia. Brain 137, 1176-1192.
20. Chare L, Hodges JR, Leyton CE, McGinley C, Tan RH, Kril JJ, Halliday GM (2014) New criteria for frontotemporal dementia syndromes: Clinical and pathological diagnostic implications. J Neurol Neurosurg Psychiatry 85, 865-870.
21. Whitwell JL, Lowe VJ, Duffy JR, Strand EA, Machulda MM, Kantarci K, Wille SM, Senjem ML, Murphy MC, Gunter JL, Jack CR Jr, Josephs KA (2013) Elevated occipital betaamyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia. J Neurol Neurosurg Psychiatry 84, 1357-1364.
22. Tang-Wai DF, Graff-Radford NR, Boeve BF, Dickson DW, Parisi JE, Crook R, Caselli RJ, Knopman DS, Petersen RC (2004) Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy. Neurology 63, 1168-1174.
23. Formaglio M, Costes N, Seguin J, Tholance Y, Le Bars D, Roullet-Solignac I, Mercier B, Krolak-Salmon P, Vighetto A (2011) In vivo demonstration of amyloid burden in posterior cortical atrophy: A case series with PET and CSF findings. J Neurol 258, 1841-1851.
24. Lehmann M, Ghosh PM, Madison C, Laforce R Jr, Corbetta-Rastelli C, Weiner MW, Greicius MD, Seeley WW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD (2013) Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease. Brain 136, 844-858.
25. Madhavan A, Whitwell JL, Weigand SD, Duffy JR, Strand EA, Machulda MM, Tosakulwong N, Senjem ML, Gunter JL, Lowe VJ, Petersen RC, Jack CR Jr, Josephs KA (2013) FDG PET and MRI in logopenic primary progressive aphasia versus dementia of the Alzheimer's type. PLoS One 8, e62471.
26. Whitwell JL, Jack CR Jr, Kantarci K, Weigand SD, Boeve BF, Knopman DS, Drubach DA, Tang-Wai DF, Petersen RC, Josephs KA (2007) Imaging correlates of posterior cortical atrophy. Neurobiol Aging 28, 1051-1061.
27. Whitwell JL, Jack CR Jr, Duffy JR, Strand EA, Gunter JL, Senjem ML, MurphyMC, Kantarci K, Machulda MM, Lowe VJ, Josephs KA (2014) Microbleeds in the logopenic variant of primary progressive aphasia. Alzheimers Dement 10, 62-66.
28. Josephs KA, Duffy JR, Strand EA, Machulda MM, Senjem ML, Master AV, Lowe VJ, Jack CR Jr, Whitwell JL (2012) Characterizing a neurodegenerative syndrome: Primary progressive apraxia of speech. Brain 135, 1522-1536.
29. Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van derKouwe A, Killiany R,Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM (2002) Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain. Neuron 33, 341-355.
30. Jack CR Jr, Lowe VJ, Senjem ML, Weigand SD, Kemp BJ, Shiung MM, Knopman DS, Boeve BF, Klunk WE, Mathis CA, Petersen RC (2008) 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain 131, 665-680.
31. Campbell I (2007) Chi-squared and Fisher-Irwin tests of twoby-two tables with small sample recommendations. Stat Med 26, 3661-3675.
32. Hilbe JM (2011) Negative binomial regression, Cambridge University Press, Cambridge, UK.
33. Nasreddine ZS, Phillips NA, Bedirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H (2005) The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53, 695-699.
34. Attems J, Jellinger KA, Lintner F (2005) Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy. Acta Neuropathol 110, 222-231.
35. Dierksen GA, Skehan ME, Khan MA, Jeng J, Nandigam RN, Becker JA, Kumar A, Neal KL, Betensky RA, Frosch MP, Rosand J, Johnson KA, Viswanathan A, Salat DH, Greenberg SM (2010) Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Ann Neurol 68, 545-548.
36. Goos JD, Teunissen CE, Veerhuis R, Verwey NA, Barkhof F, Blankenstein MA, Scheltens P, van der Flier WM (2012) Microbleeds relate to altered amyloid-beta metabolism in Alzheimer's disease. Neurobiol Aging 33, 1011 e1011-1019.
37. Benedictus MR, Goos JD, Binnewijzend MA, Muller M, Barkhof F, Scheltens P, Prins ND, van der Flier WM (2013) Specific risk factors for microbleeds and white matter hyperintensities in Alzheimer's disease. Neurobiol Aging 34, 2488-2494.
38. Park JH, Seo SW, Kim C, Kim GH, Noh HJ, Kim ST, Kwak KC, Yoon U, Lee JM, Lee JW, Shin JS, Kim CH, Noh Y, Cho H, Kim HJ, Yoon CW, Oh SJ, Kim JS, Choe YS, Lee KH, Lee JH, Ewers M, Weiner MW, Werring DJ, Na DL (2013) Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment. Ann Neurol 73, 584-593.
39. Boche D, Zotova E, Weller RO, Love S, Neal JW, Pickering RM, Wilkinson D, Holmes C, Nicoll JA (2008) Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain 131, 3299-3310.