Elevated occipital β-amyloid deposition is associated with widespread cognitive impairment in logopenic progressive aphasia

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 84, Issue 12, 2013, Pages 1357-1364

  Whitwell, Jennifer L ^a   Lowe, Val J ^a   Duffy, Joseph R ^a   Strand, Edythe A ^a   Machulda, Mary M ^a   Kantarci, Kejal ^a   Wille, Samantha M ^a   Senjem, Matthew L ^a   Murphy, Matthew C ^a   Gunter, Jeffrey L ^a   Jack, Clifford R ^a   Josephs, Keith A ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; FLUORODEOXYGLUCOSE F 18; HEMOSIDERIN; PITTSBURGH COMPOUND B;

ADULT; AGED; ANTERIOR CINGULATE; ARTICLE; BRAIN ATROPHY; BRAIN HEMORRHAGE; BRAIN METABOLISM; CASE CONTROL STUDY; CLINICAL ARTICLE; COGNITIVE DEFECT; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FRONTAL LOBE; HUMAN; INFERIOR TEMPORAL LOBE; LOGOPENIC VARIANT OF PRIMARY PROGRESSIVE APHASIA; MALE; MOTOR CORTEX; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL LOBE; PARIETAL LOBE; POSITRON EMISSION TOMOGRAPHY; POSTERIOR CINGULATE; PRECUNEUS; PREFRONTAL CORTEX; PRIMARY PROGRESSIVE APHASIA; PRIORITY JOURNAL; TEMPORAL LOBE; WHITE MATTER;

EID: 84888039861     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp-2013-305628     Document Type: Article

References (40)

1. Gorno-Tempini ML, Dronkers NF, Rankin KP, et al. Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol 2004;55:335-46.
2. Josephs KA, Duffy JR, Fossett TR, et al. Fluorodeoxyglucose F18 positron emission tomography in progressive apraxia of speech and primary progressive aphasia variants. Arch Neurol 2010;67:596-605.
3. Josephs KA, Whitwell JL, Duffy JR, et al. Progressive aphasia secondary to Alzheimer disease vs FTLD pathology. Neurology 2008;70:25 -34.
4. Lehmann M, Ghosh PM, Madison C, et al . Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease. Brain 2013;136:844-58.
5. Mesulam M, Wicklund A, Johnson N, et al . Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Ann Neurol 2008;63:709- 19.
6. Deramecourt V, Lebert F, Debachy B, et al. Prediction of pathology in primary progressive language and speech disorders. Neurology 2010;74:42-9.
7. Rabinovici GD, Jagust WJ, Furst AJ, et al. Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia. Ann Neurol 2008;64:388-401.
8. Leyton CE, Villemagne VL, Savage S, et al. Subtypes of progressive aphasia: application of the International Consensus Criteria and validation using beta-amyloid imaging. Brain 2011;134:3030-43.
9. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239 -59.
10. Jack CR Jr, Lowe VJ, Senjem ML, et al. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain 2008;131:665-80.
11. Rowe CC, Ng S, Ackermann U, et al. Imaging beta-amyloid burden in aging and dementia. Neurology 2007;68:1718 -25.
12. Whitwell JL, Jack CR Jr, Duffy JR, et al. Microbleeds in the logopenic variant of primary progressive aphasia. Alzheimer's & Demen 2013;Epub.
13. Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005;53:695-9.
14. Knopman DS, Kramer JH, Boeve BF, et al. Development of methodology for conducting clinical trials in frontotemporal lobar degeneration. Brain 2008;131:2957-68.
15. Kertesz A, Davidson W, Fox H. Frontal behavioral inventory: diagnostic criteria for frontal lobe dementia. Can J Neurol Sci 1997;24:29-36.
16. Kertesz A. Western aphasia battery (revised) . San Antonio, TX: PsychCorp, 2007.
17. Wertz RT, Keith RL, Custer DD. Normal and aphasic behavior on a measure of auditory input and a measure of verbal output. Annual Convention of the American Speech and Hearing Association; 1971; Chicago.
18. Lansing AE, Ivnik RJ, Cullum CM, et al. An empirically derived short form of the Boston naming test. Arch Clin Neuropsychol 1999;14:481-7.
19. Spreen O, Strauss E. Compendium of neuropsychological tests, second edition: administration, norms and commentary. New York: Oxford University Press, 1998.
20. Rey A. L'examen clinique en psychologie. Paris: Presses Universitaires de France, 1964.
21. Osterrieth PA. Le test de copie d'une figure complexe. Arch Psychol 1944;30:206-56.
22. Warrington EK, James M. The visual object and space perception battery. Bury St Edmonds, UK: Thames Valley Test Company, 1991.
23. Steinberg BA, Bieliauskas LA, Smith GE, et al. Mayo's older Americans normative studies: age- and IQ-adjusted norms for the trail-making test, the stroop test, and MAE controlled oral word association test. Clin Neuropsychol 2005;19:329-77.
24. Steinberg BA, Bieliauskas LA, Smith GE, et al. Mayo's older Americans normative studies: age- and IQ-adjusted norms for the auditory verbal learning test and the visual spatial learning test. Clin Neuropsychol 2005;19:464-523.
25. Machulda MM, Ivnik RJ, Smith GE, et al. Mayo's older Americans normative studies: visual form discrimination and copy trial of the rey-osterrieth complex figure. J Clin Exp Neuropsychol 2007;29:377-84.
26. Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology 2011;76:1006-14.
27. Mirra SS, Heyman A, McKeel D, et al. The Consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991;41:479-86.
28. Josephs KA, Duffy JR, Strand EA, et al. Characterizing a neurodegenerative syndrome: primary progressive apraxia of speech. Brain 2012;135:1522-36.
29. Vemuri P, Gunter JL, Senjem ML, et al. Alzheimer's disease diagnosis in individual subjects using structural MR images: validation studies. Neuroimage 2008;39:1186-97.
30. Ashburner J, Friston KJ. Unified segmentation. Neuroimage 2005;26:839-51.
31. Kantarci K, Gunter JL, Tosakulwong N, et al. Focal hemosiderin deposits and beta-amyloid load in the ADNI cohort. Alzheimers Demen 2013; Jan 30 [Epub] doi: 10.1016/j.alz.2012.10.011
32. Jack CR Jr, O'Brien PC, Rettman DW, et al. FLAIR histogram segmentation for measurement of leukoaraiosis volume. J Magn Reson Imaging 2001;14:668-76.
33. Working Group. Consensus recommendation for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for Neuropathologic Assessment of Alzheimer's Disease. Neurobiology Aging 1997;18(Supp1):S1-2.
34. Chowdhury MH, Nagai A, Bokura H, et al. Age-related changes in white matter lesions, hippocampal atrophy, and cerebral microbleeds in healthy subjects without major cerebrovascular risk factors. J Stroke Cerebrovasc Dis 2011;20:302-9.
35. Hedden T, Mormino EC, Amariglio RE, et al. Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults. J Neurosci 2012;32:16233-42.
36. Pettersen JA, Sathiyamoorthy G, Gao FQ, et al. Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study. Arch Neurol 2008;65:790-5.
37. Schrag M, McAuley G, Pomakian J, et al. Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy: a postmortem MRI study. Acta Neuropathol 2010;119:291-302.
38. Bacskai BJ, Frosch MP, Freeman SH, et al. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol 2007;64:431-4.
39. Ly JV, Donnan GA, Villemagne VL, et al. 11C-PIB binding is increased in patients with cerebral amyloid angiopathy-related hemorrhage. Neurology 2010;74:487-93.
40. Lehmann M, Barnes J, Ridgway GR, et al. Basic visual function and cortical thickness patterns in posterior cortical atrophy. Cerebral cortex 2011;21:2122-32.