Graves' disease is associated with a defective expression of the immune regulatory molecule galectin-9 in antigen-presenting dendritic cells

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Leskela, Susanna ^a   Serrano, Ana ^a   De La Fuente, Hortensia ^a   Rodríguez Muñoz, Ana ^a   Ramos Levi, Ana ^a   Sampedro Nuñez, Miguel ^a   Sánchez Madrid, Francisco ^a   González Amaro, Roberto ^b   Marazuela, Mónica ^a  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ECALECTIN; GALECTIN 1; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN TIM 3; UNCLASSIFIED DRUG; CYTOKINE; GALECTIN; LGALS1 PROTEIN, HUMAN; LGALS9 PROTEIN, HUMAN;

ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDOCRINE OPHTHALMOPATHY; FLOW CYTOMETRY; GAL 9 GENE; GENE EXPRESSION; GRAVES DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOPATHOGENESIS; IN VITRO STUDY; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ADULT; AUTOIMMUNE THYROIDITIS; CASE CONTROL STUDY; CELL CULTURE; DRUG EFFECTS; FEMALE; GENETICS; GOITER; HASHIMOTO DISEASE; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; TH1 CELL; TH17 CELL; TH2 CELL;

ADULT; CASE-CONTROL STUDIES; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; FEMALE; GALECTIN 1; GALECTINS; GOITER; GRAVES DISEASE; HASHIMOTO DISEASE; HUMANS; MALE; MIDDLE AGED; TH1 CELLS; TH17 CELLS; TH2 CELLS; THYROIDITIS, AUTOIMMUNE;

EID: 84928136044     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0123938     Document Type: Article

References (28)

1. Weetman AP (2004) Cellular immune responses in autoimmune thyroid disease. Clin Endocrinol (Oxf) 61: 405-413. PMID: 15473869
2. Wiersinga WM (2011) Autoimmunity in Graves' ophthalmopathy: the result of an unfortunate marriage between TSH receptors and IGF-1 receptors?. J Clin Endocrinol Metab 96: 2386-2394. doi: 10.1210/jc.2011-0307 PMID: 21677036
3. Prabhakar BS, Bahn RS, Smith TJ (2003) Current perspective on the pathogenesis of Graves' disease and ophthalmopathy. Endocr Rev 24: 802-835. PMID: 14671007
4. Rabinovich GA, Toscano MA (2009) Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat Rev Immunol 9: 338-352. doi: 10.1038/nri2536 PMID: 19365409
5. de la Fuente H, Cibrian D, Sanchez-Madrid F (2012) Immunoregulatory molecules are master regulators of inflammation during the immune response. FEBS Lett 586: 2897-2905. doi: 10.1016/j.febslet.2012.07.032 PMID: 22819828
6. Chou FC, Shieh SJ, Sytwu HK (2009) Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice. Eur J Immunol 39: 2403-2411. doi: 10.1002/eji.200839177 PMID: 19670381
7. Seki M, Oomizu S, Sakata KM, Sakata A, Arikawa T, Watanabe K, et al. (2008) Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis. Clin Immunol 127: 78-88. doi: 10.1016/j.clim.2008.01.006 PMID: 18282810
8. Katoh S, Ishii N, Nobumoto A, Takeshita K, Dai SY, Shinonaga R, et al. (2007) Galectin-9 inhibits CD44-hyaluronan interaction and suppresses a murine model of allergic asthma. Am J Respir Crit Care Med 176: 27-35. PMID: 17446336
9. Arikawa T, Watanabe K, Seki M, Matsukawa A, Oomizu S, Sakata KM, et al. (2009) Galectin-9 ameliorates immune complex-induced arthritis by regulating Fc gamma R expression on macrophages. Clin Immunol 133: 382-392. doi: 10.1016/j.clim.2009.09.004 PMID: 19800850
10. Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, et al. (2007) Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol 8: 825-834. PMID: 17589510
11. van der Leij J, van den Berg A, Blokzijl T, Harms G, van Goor H, Zwiers P, et al. (2004) Dimeric galectin-1 induces IL-10 production in T-lymphocytes: an important tool in the regulation of the immune response. J Pathol 204: 511-518. PMID: 15538736
12. Figueroa-Vega N, Alfonso-Perez M, Benedicto I, Sanchez-Madrid F, Gonzalez-Amaro R, Marazuela M (2010) Increased circulating pro-inflammatory cytokines and Th17 lymphocytes in Hashimoto's thyroiditis. J Clin Endocrinol Metab 95: 953-962. doi: 10.1210/jc.2009-1719 PMID: 20016049
13. Marazuela M, Garcia-Lopez MA, Figueroa-Vega N, de la Fuente H, Alvarado-Sanchez B, Monsiváis-Urenda A, et al. (2006) Regulatory T cells in human autoimmune thyroid disease. J Clin Endocrinol Metab 91: 3639-3646. PMID: 16804051
14. Ruiz-Riol M, Barnils M P, Colobran Oriol R, Pla AS, Borras Serres FE, Lucas-Martin A, et al. (2011) Analysis of the cumulative changes in Graves' disease thyroid glands points to IFN signature, plasmacytoid DCs and alternatively activated macrophages as chronicity determining factors. J Autoimmun 36: 189-200. doi: 10.1016/j.jaut.2011.01.002 PMID: 21354768
15. Mao C, Wang S, Xiao Y, Xu J, Jiang Q, Jin M, et al. (2011) Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease. J Immunol 186: 4734-4743. doi: 10.4049/jimmunol.0904135 PMID: 21398613
16. Leskela S, Rodriguez-Munoz A, de la Fuente H, Figueroa-Vega N, Bonay P, Martín P, et al. (2013). Plasmacytoid dendritic cells in patients with autoimmune thyroid disease. J Clin Endocrinol Metab 98: 2822-2833. doi: 10.1210/jc.2013-1273 PMID: 23666960
17. Bartalena L, Baldeschi L, Dickinson A, Eckstein A, Kendall-Taylor P, Marcocci C, et al. (2008) Consensus statement of the European Group on Graves' orbitopathy (EUGOGO) on management of GO. Eur J Endocrinol 158: 273-285. doi: 10.1530/EJE-07-0666 PMID: 18299459
18. Figueroa-Vega N, Sanz-Cameno P, Moreno-Otero R, Sanchez-Madrid F, Gonzalez-Amaro R, Marazuela M (2009) Serum levels of angiogenic molecules in autoimmune thyroid diseases and their correlation with laboratory and clinical features. J Clin Endocrinol Metab 94: 1145-1153. doi: 10.1210/jc.2008-1571 PMID: 19141578
19. Mascanfroni ID, Cerliani JP, Dergan-Dylon S, Croci DO, Ilarregui JM, Rabinovich GA. (2011) Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: mechanisms and biomedical applications. Int Immunopharmacol 11: 833-841. doi: 10.1016/j.intimp.2011.01.021 PMID: 21296197
20. Blaser C, Kaufmann M, Muller C, Zimmermann C, Wells V, Mallucci L, et al. (1998) Beta-galactoside-binding protein secreted by activated T cells inhibits antigen-induced proliferation of T cells. Eur J Immunol 28: 2311-2319. PMID: 9710209
21. Perillo NL, Marcus ME, Baum LG (1998) Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death. J Mol Med (Berl) 76: 402-412. PMID: 9625297
22. Cooper D, Norling LV, Perretti M (2008) Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukoc Biol 83: 1459-1466. doi: 10.1189/jlb.1207831 PMID: 18372340
23. Norling LV, Sampaio AL, Cooper D, Perretti M (2008) Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. FASEB J 22: 682-690. PMID: 17965266
24. Demetriou M, Granovsky M, Quaggin S, Dennis JW (2001) Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation. Nature 409: 733-739. PMID: 11217864
25. Seki M, Sakata KM, Oomizu S, Arikawa T, Sakata A, Watanabe K, et al. (2007) Beneficial effect of galectin 9 on rheumatoid arthritis by induction of apoptosis of synovial fibroblasts. Arthritis Rheum 56: 3968-3976. PMID: 18050192
26. Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, et al. (2002) Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-541. PMID: 11823861
27. Kanzaki M, Wada J, Sugiyama K, Nakatsuka A, Teshigawara S, Murakami K, et al. (2012) Galectin-9 and T cell immunoglobulin mucin-3 pathway is a therapeutic target for type 1 diabetes. Endocrinology 153: 612-620. doi: 10.1210/en.2011-1579 PMID: 22186414
28. Imaizumi T, Kumagai M, Sasaki N, Kurotaki H, Mori F, Seki M, et al. (2002) Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells. J Leukoc Biol 72: 486-491. PMID: 12223516