Is urinary lipoarabinomannan the result of renal tuberculosis? Assessment of the renal histology in an autopsy cohort of ugandan HIV-infected adults

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Cox, Janneke A ^a,b   Lukande, Robert L ^c   Kalungi, Sam ^c,d   Van Marck, Eric ^e   Van De Vijver, Koen ^f   Kambugu, Andrew ^b   Nelson, Ann M ^g   Colebunders, Robert ^a,h   Manabe, Yukari C ^b,i  

^a INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^b MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

^c MAKERERE UNIVERSITY   (Uganda)

^d MULAGO HOSPITAL   (Uganda)

^e ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^f ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^g JOINT PATHOLOGY CENTER   (United States)

^h UNIVERSITY OF ANTWERP   (Belgium)

ⁱ JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; LIPOARABINOMANNAN; TUBERCULOSTATIC AGENT; BIOLOGICAL MARKER; LIPOPOLYSACCHARIDE;

ADULT; ARTICLE; AUTOPSY; BACTERIAL INFECTION; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DEATH; DIAGNOSTIC TEST ACCURACY STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOASSAY; KIDNEY TUBERCULOSIS; LATERAL FLOW ASSAY; MALE; MIDDLE AGED; MILIARY TUBERCULOSIS; MYCOSIS; SENSITIVITY AND SPECIFICITY; UGANDAN; URINE LEVEL; YOUNG ADULT; KIDNEY; MICROBIOLOGY; PATHOLOGY; UGANDA; URINE;

BACTERIA (MICROORGANISMS);

ADULT; BIOMARKERS; COHORT STUDIES; FEMALE; HIV INFECTIONS; HUMANS; KIDNEY; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; TUBERCULOSIS, RENAL; UGANDA;

EID: 84928111352     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0123323     Document Type: Article

References (35)

1. UNAIDS. AIDS by the numbers. 2013. Available: http://www.unaids.org/sites/default/files/media-asset/JC2571-AIDS-by-the-numbers-en-1.pdf
2. World Health Organisation. Global tuberculosis report 2013. 2013. Available: http://apps.who.int/iris/bitstream/10665/91355/1/9789241564656-eng.pdf
3. World Health Organisation. Estimates of TB and MDR-TB burden. Uganda Tuberculosis Profile. 2015. Available: https://extranet.who.int/sree/Reports?op=Replet&name=/WHO-HQ-Reports/G2/PROD/EXT/TBCountryProfile&ISO2=UG&outtype=PDF
4. Gupta RK, Lawn SD, Bekker LG, Caldwell J, Kaplan R, Wood R. Impact of human immunodeficiency virus and CD4 count on tuberculosis diagnosis: analysis of city-wide data from Cape Town, South Africa. Int J Tuberc Lung Dis. 2013; 17(8):1014-22. Epub 2013/07/06. doi: 10.5588/ijtld.13.0032 PMID: 23827024.
5. Fenner L, Ballif M, Graber C, Nhandu V, Dusingize JC, Cortes CP, et al. Tuberculosis in antiretroviral treatment programs in lower income countries: availability and use of diagnostics and screening. PLoS One. 2013; 8(10):e77697. Epub 2013/10/23. doi: 10.1371/journal.pone.0077697 PMID: 24147059; PubMed Central PMCID: PMC3798412.
6. Kivihya-Ndugga LE, van Cleeff MR, Githui WA, Nganga LW, Kibuga DK, Odhiambo JA, et al. A comprehensive comparison of Ziehl-Neelsen and fluorescence microscopy for the diagnosis of tuberculosis in a resource-poor urban setting. Int J Tuberc Lung Dis. 2003; 7(12):1163-71. Epub 2003/12/18. PMID: 14677891.
7. Chihota VN, Grant AD, Fielding K, Ndibongo B, van Zyl A, Muirhead D, et al. Liquid vs. solid culture for tuberculosis: performance and cost in a resource-constrained setting. Int J Tuberc Lung Dis. 2010; 14 (8):1024-31. Epub 2010/07/16. PMID: 20626948.
8. Trebucq A, Enarson DA, Chiang CY, Van Deun A, Harries AD, Boillot F, et al. Xpert(R) MTB/RIF for national tuberculosis programmes in low-income countries: when, where and how? Int J Tuberc Lung Dis. 2011; 15(12):1567-72. Epub 2011/10/19. doi: 10.5588/ijtld.11.0392 PMID: 22005110.
9. World Health Organisation. Policy statement: automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF system. 2011. Available: http://apps.who.int/iris/bitstream/10665/44586/1/9789241501545-eng.pdf?ua=1
10. Theron G, Peter J, van Zyl-Smit R, Mishra H, Streicher E, Murray S, et al. Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting. Am J Respir Crit Care Med. 2011; 184(1):132-40. Epub 2011/04/16. doi: 10.1164/rccm.201101-0056OC PMID: 21493734.
11. Dheda K, Davids V, Lenders L, Roberts T, Meldau R, Ling D, et al. Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples. PLoS One. 2010; 5(3):e9848. Epub 2010/03/31. doi: 10.1371/journal.pone.0009848 PMID: 20352098; PubMed Central PMCID: PMC2844421.
12. Shah M, Variava E, Holmes CB, Coppin A, Golub JE, McCallum J, et al. Diagnostic accuracy of a urine lipoarabinomannan test for tuberculosis in hospitalized patients in a High HIV prevalence setting. J Acquir Immune Defic Syndr. 2009; 52(2):145-51. Epub 2009/08/21. doi: 10.1097/QAI. 0b013e3181b98430 PMID: 19692904; PubMed Central PMCID: PMC2815254.
13. Sada E, Aguilar D, Torres M, Herrera T. Detection of lipoarabinomannan as a diagnostic test for tuberculosis. J Clin Microbiol. 1992; 30(9):2415-8. Epub 1992/09/01. PMID: 1401008; PubMed Central PMCID: PMC265515.
14. Patel VB, Bhigjee AI, Paruk HF, Singh R, Meldau R, Connolly C, et al. Utility of a novel lipoarabinomannan assay for the diagnosis of tuberculous meningitis in a resource-poor high-HIV prevalence setting. Cerebrospinal Fluid Res. 2009; 6:13. Epub 2009/11/03. doi: 10.1186/1743-8454-6-13 PMID: 19878608; PubMed Central PMCID: PMC2777116.
15. Mishra AK, Driessen NN, Appelmelk BJ, Besra GS. Lipoarabinomannan and related glycoconjugates: structure, biogenesis and role in Mycobacterium tuberculosis physiology and host-pathogen interaction. FEMS Microbiol Rev. 2011; 35(6):1126-57. Epub 2011/04/28. doi: 10.1111/j.1574-6976.2011. 00276.x PMID: 21521247; PubMed Central PMCID: PMC3229680.
16. Lawn SD, Edwards DJ, Kranzer K, Vogt M, Bekker LG, Wood R. Urine lipoarabinomannan assay for tuberculosis screening before antiretroviral therapy diagnostic yield and association with immune reconstitution disease. Aids. 2009; 23(14):1875-80. Epub 2010/01/29. PMID: 20108382.
17. Gounder CR, Kufa T, Wada NI, Mngomezulu V, Charalambous S, Hanifa Y, et al. Diagnostic accuracy of a urine lipoarabinomannan enzyme-linked immunosorbent assay for screening ambulatory HIV-infected persons for tuberculosis. J Acquir Immune Defic Syndr. 2011; 58(2):219-23. Epub 2011/07/19. doi: 10.1097/QAI.0b013e31822b75d4 PMID: 21765364; PubMed Central PMCID: PMC3175281.
18. Lawn SD, Kerkhoff AD, Vogt M, Wood R. Diagnostic accuracy of a low-cost, urine antigen, point-ofcare screening assay for HIV-associated pulmonary tuberculosis before antiretroviral therapy: a descriptive study. Lancet Infect Dis. 2012; 12(3):201-9. Epub 2011/10/22. doi: 10.1016/S1473-3099(11) 70251-1 PMID: 22015305; PubMed Central PMCID: PMC3315025.
19. Peter JG, Theron G, van Zyl-Smit R, Haripersad A, Mottay L, Kraus S, et al. Diagnostic accuracy of a urine lipoarabinomannan strip-test for TB detection in HIV-infected hospitalised patients. Eur Respir J. 2012; 40(5):1211-20. Epub 2012/03/01. doi: 10.1183/09031936.00201711 PMID: 22362849.
20. Nakiyingi L, Moodley VM, Manabe YC, Nicol MP, Holshouser M, Armstrong DT, et al. Diagnostic accuracy of a rapid urine lipoarabinomannan test for tuberculosis in HIV-infected adults. J Acquir Immune Defic Syndr. 2014; 66(3):270-9. doi: 10.1097/QAI.0000000000000151 PMID: 24675585; PubMed Central PMCID: PMC4146703.
21. Wood R, Racow K, Bekker LG, Middelkoop K, Vogt M, Kreiswirth BN, et al. Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria. BMC Infect Dis. 2012; 12:47. Epub 2012/03/01. doi: 10.1186/1471-2334-12-47 PMID: 22369353; PubMed Central PMCID: PMC3349560.
22. Martinson NA, Karstaedt A, Venter WD, Omar T, King P, Mbengo T, et al. Causes of death in hospitalized adults with a premortem diagnosis of tuberculosis: an autopsy study. Aids. 2007; 21(15):2043-50. Epub 2007/09/22. doi: 10.1097/QAD.0b013e3282eea47f PMID: 17885294.
23. Ansari NA, Kombe AH, Kenyon TA, Hone NM, Tappero JW, Nyirenda ST, et al. Pathology and causes of death in a group of 128 predominantly HIV-positive patients in Botswana, 1997-1998. Int J Tuberc Lung Dis. 2002; 6(1):55-63. Epub 2002/04/05. PMID: 11931402.
24. Rana FS, Hawken MP, Mwachari C, Bhatt SM, Abdullah F, Ng'ang'a LW, et al. Autopsy study of HIV-1-positive and HIV-1-negative adult medical patients in Nairobi, Kenya. J Acquir Immune Defic Syndr. 2000; 24(1):23-9. Epub 2000/07/06. PMID: 10877491.
25. Cox JA, Lukande RL, Kalungi S, Van Marck E, Van de Vijver K, Kambugu A, et al. Needle autopsy to establish the cause of death in HIV-infected hospitalized adults in Uganda: a comparison to complete autopsy. J Acquir Immune Defic Syndr. 2014; 67(2):169-76. doi: 10.1097/QAI.0000000000000290 PMID: 25072614.
26. Myers BD, Guasch A. Selectivity of the glomerular filtration barrier in healthy and nephrotic humans. Am J Nephrol. 1993; 13(5):311-7. Epub 1993/01/01. PMID: 8116683.
27. Tessema TA, Bjune G, Hamasur B, Svenson S, Syre H, Bjorvatn B. Circulating antibodies to lipoarabinomannan in relation to sputum microscopy, clinical features and urinary anti-lipoarabinomannan detection in pulmonary tuberculosis. Scand J Infect Dis. 2002; 34(2):97-103. Epub 2002/04/04. PMID: 11928861.
28. Da Costa CT, Khanolkar-Young S, Elliott AM, Wasunna KM, McAdam KP. Immunoglobulin G subclass responses to mycobacterial lipoarabinomannan in HIV-infected and non-infected patients with tuberculosis. Clin Exp Immunol. 1993; 91(1):25- 9. Epub 1993/01/01. PMID: 8419082; PubMed Central PMCID: PMC1554641.
29. Reither K, Saathoff E, Jung J, Minja LT, Kroidl I, Saad E, et al. Low sensitivity of a urine LAM-ELISA in the diagnosis of pulmonary tuberculosis. BMC Infect Dis. 2009; 9:141. Epub 2009/09/01. doi: 10.1186/1471-2334-9-141 PMID: 19715562; PubMed Central PMCID: PMC2741465.
30. Hunter SW, Gaylord H, Brennan PJ. Structure and antigenicity of the phosphorylated lipopolysaccharide antigens from the leprosy and tubercle bacilli. J Biol Chem. 1986; 261(26):12345-51. Epub 1986/09/15. PMID: 3091602.
31. Symes JM, Blandy JP. Tuberculosis of the male urethra. Br J Urol. 1973; 45(4):432-6. Epub 1973/08/01. PMID: 4199709.
32. Schubert GE, Haltaufderheide T, Golz R. Frequency of urogenital tuberculosis in an unselected autopsy series from 1928 to 1949 and 1976 to 1989. Eur Urol. 1992; 21(3):216-23. Epub 1992/01/01. PMID: 1499628.
33. Shah M, Martinson NA, Chaisson RE, Martin DJ, Variava E, Dorman SE. Quantitative analysis of a urine-based assay for detection of lipoarabinomannan in patients with tuberculosis. J Clin Microbiol. 2010; 48(8):2972-4. doi: 10.1128/JCM.00363-10 PMID: 20534796; PubMed Central PMCID: PMC2916614.
34. Kroidl I, Clowes P, Mwakyelu J, Maboko L, Kiangi A, Rachow A, et al. Reasons for false-positive lipoarabinomannan ELISA results in a Tanzanian population. Scand J Infect Dis. 2013. Epub 2013/11/28. doi: 10.3109/00365548.2013.853133 PMID: 24274710.
35. Boehme C, Molokova E, Minja F, Geis S, Loscher T, Maboko L, et al. Detection of mycobacterial lipoarabinomannan with an antigen-capture ELISA in unprocessed urine of Tanzanian patients with suspected tuberculosis. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2005; 99 (12):893-900. doi: 10.1016/j.trstmh.2005.04.014 PMID: 16139316.