Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity

Cancer Science

Volumn 106, Issue 4, 2015, Pages 413-420

  Jeon, Yoon Jung ^a,b   Jung, Seung Nam ^a   Yun, Jieun ^a,b   Lee, Chang Woo ^a   Choi, Jiyeon ^a,c   Lee, Yu Jin ^a,b   Han, Dong Cho ^a,b   Kwon, Byoung Mog ^a,b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Chungnam National University   (South Korea)

Author keywords

Apoptosis; Biflavonoid; Ginkgetin; Prostate cancer; STAT3

Indexed keywords

CYCLIN D1; GINKGETIN; GINKGO BILOBA EXTRACT; PROTEIN BCL 2; PROTEIN BCL XL; STAT3 PROTEIN; SURVIVIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BIFLAVONOID; BIRC5 PROTEIN, MOUSE; CCND1 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; INTERLEUKIN 6; REPRESSOR PROTEIN; STAT3 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL GROWTH; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG ISOLATION; FEMALE; GINKGO BILOBA; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PLANT LEAF; PRIORITY JOURNAL; PROSTATE CANCER CELL LINE; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; ACTIVE TRANSPORT; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL PROLIFERATION; DRUG EFFECTS; DRUG SCREENING; G1 PHASE CELL CYCLE CHECKPOINT; HCT116 CELL LINE; MALE; METABOLISM; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; PROSTATE; PROSTATIC NEOPLASMS; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIFLAVONOIDS; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN D1; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; GINKGO BILOBA; HCT116 CELLS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INTERLEUKIN-6; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; PHOSPHORYLATION; PROSTATE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; REPRESSOR PROTEINS; STAT3 TRANSCRIPTION FACTOR; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84928084159     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12608     Document Type: Article

References (37)

1. Nobili S, Lippi D, Witort E et al. Natural compounds for cancer treatment and prevention. Pharmacol Res 2009; 59: 365-78.
2. Gupta SC, Kim JH, Prasad S, Aggarwal BB. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev 2010; 29: 405-34.
3. Bromberg JF, Wrzeszczynska MH, Devgan G et al. Stat3 as an oncogene. Cell 1999; 98: 295-303.
4. Wang H, Lafdil F, Kong X, Gao B. Signal transducer and activator of transcription 3 in liver diseases: a novel therapeutic target. Int J Biol Sci 2011; 7: 536-50.
5. Yu CL, Jove R, Burakoff SJ. Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase. J Immunol 1997; 159: 5206-10.
6. Sartor CI, Dziubinski ML, Yu CL, Jove R, Ethier SP. Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. Cancer Res 1997; 57: 978-87.
7. Corvinus FM, Orth C, Moriggl R et al. Persistent STAT3 activation in colon cancer is associated with enhanced cell proliferation and tumor growth. Neoplasia 2005; 7: 545-55.
8. Abdulghani J, Gu L, Dagvadorj A et al. Stat3 promotes metastatic progression of prostate cancer. Am J Pathol 2008; 172: 1717-28.
9. Becker S, Groner B, Muller CW. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature 1998; 394: 145-51.
10. Darnell JE Jr, Kerr IM, Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994; 264: 1415-21.
11. Hirano T, Ishihara K, Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 2000; 19: 2548-56.
12. Fletcher S, Drewry JA, Shahani VM, Page BD, Gunning PT. Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein. Biochem Cell Biol 2009; 87: 825-33.
13. Jing N, Tweardy DJ. Targeting Stat3 in cancer therapy. Anticancer Drugs 2005; 16: 601-7.
14. Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics, 1999. CA Cancer J Clin 1999; 49: 8-31, 1.
15. Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61: 212-36.
16. Mora LB, Buettner R, Seigne J et al. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer Res 2002; 62: 6659-66.
17. Horinaga M, Okita H, Nakashima J, Kanao K, Sakamoto M, Murai M. Clinical and pathologic significance of activation of signal transducer and activator of transcription 3 in prostate cancer. Urology 2005; 66: 671-5.
18. Lee SO, Lou W, Hou M, de Miguel F, Gerber L, Gao AC. Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells. Clin Cancer Res 2003; 9: 370-6.
19. Barton BE, Karras JG, Murphy TF, Barton A, Huang HF. Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: direct STAT3 inhibition induces apoptosis in prostate cancer lines. Mol Cancer Ther 2004; 3: 11-20.
20. Arya M, Bott SR, Shergill IS, Ahmed HU, Williamson M, Patel HR. The metastatic cascade in prostate cancer. Surg Oncol 2006; 15: 117-28.
21. Oyama Y, Fuchs PA, Katayama N, Noda K. Myricetin and quercetin, the flavonoid constituents of Ginkgo biloba extract, greatly reduce oxidative metabolism in both resting and Ca(2+)-loaded brain neurons. Brain Res 1994; 635: 125-9.
22. Su Y, Sun CM, Chuang HH, Chang PT. Studies on the cytotoxic mechanisms of ginkgetin in a human ovarian adenocarcinoma cell line. Naunyn Schmiedebergs Arch Pharmacol 2000; 362: 82-90.
23. Lee SJ, Choi JH, Son KH, Chang HW, Kang SS, Kim HP. Suppression of mouse lymphocyte proliferation in vitro by naturally-occurring biflavonoids. Life Sci 1995; 57: 551-8.
24. Kim HK, Son KH, Chang HW, Kang SS, Kim HP. Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from Ginkgo biloba leaves. Planta Med 1999; 65: 465-7.
25. Kwak WJ, Han CK, Son KH et al. Effects of Ginkgetin from Ginkgo biloba Leaves on cyclooxygenases and in vivo skin inflammation. Planta Med 2002; 68: 316-21.
26. Kang SS, Kim JS, Kwak WJ, Kim KH. Flavonoids from the leaves of Ginkgo biloba, Korea. J Pharmacogn 1990; 21: 111-20.
27. Shin DS, Kim HN, Shin KD et al. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res 2009; 69: 193-202.
28. Tsui KH, Lin YF, Chen YH, Chang PL, Juang HH. Mechanisms by which interleukin-6 regulates prostate-specific antigen gene expression in prostate LNCaP carcinoma cells. J Androl 2011; 32: 383-93.
29. Kim DJ, Tremblay ML, DiGiovanni J. Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation. PLoS One 2010; 5: e10290.
30. Kim SJ, Lim MH, Chun IK, Won YH. Effects of flavonoids of Ginkgo biloba on proliferation of human skin fibroblast. Skin Pharmacol 1997; 10: 200-5.
31. Lim H, Son KH, Chang HW, Kang SS, Kim HP. Effects of anti-inflammatory biflavonoid, ginkgetin, on chronic skin inflammation. Biol Pharm Bull 2006; 29: 1046-9.
32. You OH, Kim SH, Kim B et al. Ginkgetin induces apoptosis via activation of caspase and inhibition of survival genes in PC-3 prostate cancer cells. Bioorg Med Chem Lett 2013; 23: 2692-5.
33. Niu G, Wright KL, Ma Y et al. Role of Stat3 in regulating p53 expression and function. Mol Cell Biol 2005; 25: 7432-40.
34. Catlett-Falcone R, Landowski TH, Oshiro MM et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999; 10: 105-15.
35. Zushi S, Shinomura Y, Kiyohara T et al. STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells. Int J Cancer 1998; 78: 326-30.
36. Page B, Ball DP, Gunning PT. Signal transducer and activator of transcription 3 inhibitors. Expert Opin Ther Pat 2011; 21: 66-83.
37. Costantino L, Barlocco D. STAT 3 as a target for cancer drug discovery. Curr Med Chem 2008; 15: 334-43.