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Volumn 26, Issue 3, 2013, Pages 269-274

New agents: Great expectations not realized

Author keywords

AC220; acute myeloid leukemia AML; clofarabine; CPX 351; FLAM; flavopiridol; FLT3 inhibitor; gemtuzumab; laromustine; lestaurtinib; lintuzumab; midostaurin; quizartinib; sapacitabine; tipifarnib

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AMONAFIDE; ANTIBIOTIC AGENT; ANTILEUKEMIC AGENT; ANTINEOPLASTIC AGENT; BORTEZOMIB; CLOFARABINE; CPX 351; CYTARABINE; DAUNORUBICIN; FLAVOPIRIDOL; GEMTUZUMAB OZOGAMICIN; LAROMUSTINE; LENALIDOMIDE; LESTAURTINIB; LINTUZUMAB; MIDOSTAURIN; MITOXANTRONE; QUIZARTINIB; SAPACITABINE; SORAFENIB; TIPIFARNIB; TROXACITABINE; UNCLASSIFIED DRUG; VALSPODAR; VORINOSTAT; VOSAROXIN; ZOSUQUIDAR;

EID: 84889647348     PISSN: 15216926     EISSN: 15321924     Source Type: Journal    
DOI: 10.1016/j.beha.2013.10.007     Document Type: Review
Times cited : (24)

References (20)
  • 1
    • 84863522871 scopus 로고    scopus 로고
    • Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia
    • A.K. Burnett, N.H. Russell, and R.K. Hills Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia J Clin Oncol 30 2012 3924 3931
    • (2012) J Clin Oncol , vol.30 , pp. 3924-3931
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3
  • 2
    • 84859911350 scopus 로고    scopus 로고
    • Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised, open-label, phase 3 study
    • S. Castaigne, C. Pautas, and C. Terre Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised, open-label, phase 3 study Lancet 379 2012 1508 1516
    • (2012) Lancet , vol.379 , pp. 1508-1516
    • Castaigne, S.1    Pautas, C.2    Terre, C.3
  • 3
    • 77957724998 scopus 로고    scopus 로고
    • Shortcomings in the clinical evaluation of new drugs: Acute myeloid leukemia as paradigm
    • R.B. Walter, F.R. Appelbaum, and M.S. Tallman Shortcomings in the clinical evaluation of new drugs: Acute myeloid leukemia as paradigm Blood 116 2010 2420 2428
    • (2010) Blood , vol.116 , pp. 2420-2428
    • Walter, R.B.1    Appelbaum, F.R.2    Tallman, M.S.3
  • 4
    • 0024536437 scopus 로고
    • Optimal two-stage designs for phase II clinical trials
    • R. Simon Optimal two-stage designs for phase II clinical trials Control Clin Trials 10 1989 1 10
    • (1989) Control Clin Trials , vol.10 , pp. 1-10
    • Simon, R.1
  • 5
    • 77649194028 scopus 로고    scopus 로고
    • Single-agent laromustine, a novel alkylating agent, has significant activity in older patients with previously untreated poor-risk acute myeloid leukemia
    • G.J. Schiller, S.M. O'Brien, and A. Pigneux Single-agent laromustine, a novel alkylating agent, has significant activity in older patients with previously untreated poor-risk acute myeloid leukemia J Clin Oncol 28 2010 815 821
    • (2010) J Clin Oncol , vol.28 , pp. 815-821
    • Schiller, G.J.1    O'brien, S.M.2    Pigneux, A.3
  • 6
    • 77449159668 scopus 로고    scopus 로고
    • Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors
    • H.M. Kantarjian, H.P. Erba, and D. Claxton Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors J Clin Oncol 28 2010 549 555
    • (2010) J Clin Oncol , vol.28 , pp. 549-555
    • Kantarjian, H.M.1    Erba, H.P.2    Claxton, D.3
  • 7
    • 69849092737 scopus 로고    scopus 로고
    • A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older
    • J.L. Harousseau, G. Martinelli, and W.W. Jedrzejczak A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older Blood 114 2009 1166 1173
    • (2009) Blood , vol.114 , pp. 1166-1173
    • Harousseau, J.L.1    Martinelli, G.2    Jedrzejczak, W.W.3
  • 8
    • 84872072793 scopus 로고    scopus 로고
    • Randomized, phase IIb study of low-dose cytarabine and lintuzumab versus low-dose cytarabine and placebo in older adults with untreated acute myeloid leukemia
    • M.A. Sekeres, J.E. Lancet, and B.L. Wood Randomized, phase IIb study of low-dose cytarabine and lintuzumab versus low-dose cytarabine and placebo in older adults with untreated acute myeloid leukemia Haematologica 98 2013 119 128
    • (2013) Haematologica , vol.98 , pp. 119-128
    • Sekeres, M.A.1    Lancet, J.E.2    Wood, B.L.3
  • 9
    • 33847001315 scopus 로고    scopus 로고
    • A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia
    • J.E. Lancet, I. Gojo, and J. Gotlib A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia Blood 109 2007 1387 1394
    • (2007) Blood , vol.109 , pp. 1387-1394
    • Lancet, J.E.1    Gojo, I.2    Gotlib, J.3
  • 10
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • J.P. Patel, M. Gonen, and M.E. Figueroa Prognostic relevance of integrated genetic profiling in acute myeloid leukemia N Engl J Med 366 2012 1079 1089
    • (2012) N Engl J Med , vol.366 , pp. 1079-1089
    • Patel, J.P.1    Gonen, M.2    Figueroa, M.E.3
  • 11
    • 41949125894 scopus 로고    scopus 로고
    • A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia
    • M. Raponi, J.E. Lancet, and H. Fan A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia Blood 111 2008 2589 2596
    • (2008) Blood , vol.111 , pp. 2589-2596
    • Raponi, M.1    Lancet, J.E.2    Fan, H.3
  • 12
    • 84864050584 scopus 로고    scopus 로고
    • Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: Results from the CLASSIC I Trial
    • S. Faderl, M. Wetzler, and D. Rizzieri Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: Results from the CLASSIC I Trial J Clin Oncol 30 2012 2492 2499
    • (2012) J Clin Oncol , vol.30 , pp. 2492-2499
    • Faderl, S.1    Wetzler, M.2    Rizzieri, D.3
  • 13
    • 84872176951 scopus 로고    scopus 로고
    • Clonal evolution of acute leukemia genomes
    • M. Jan, and R. Majeti Clonal evolution of acute leukemia genomes Oncogene 32 2013 135 140
    • (2013) Oncogene , vol.32 , pp. 135-140
    • Jan, M.1    Majeti, R.2
  • 14
    • 55049108527 scopus 로고    scopus 로고
    • In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy
    • P. Tardi, S. Johnstone, and N. Harasym In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy Leuk Res 33 2009 129 139
    • (2009) Leuk Res , vol.33 , pp. 129-139
    • Tardi, P.1    Johnstone, S.2    Harasym, N.3
  • 15
    • 79952757852 scopus 로고    scopus 로고
    • First-in-man study of CPX-351: A liposomal carrier containing cytarabine and daunorubicin in a fixed 5:1 molar ratio for the treatment of relapsed and refractory acute myeloid leukemia
    • E.J. Feldman, J.E. Lancet, and J.E. Kolitz First-in-man study of CPX-351: A liposomal carrier containing cytarabine and daunorubicin in a fixed 5:1 molar ratio for the treatment of relapsed and refractory acute myeloid leukemia J Clin Oncol 29 2011 979 985
    • (2011) J Clin Oncol , vol.29 , pp. 979-985
    • Feldman, E.J.1    Lancet, J.E.2    Kolitz, J.E.3
  • 16
    • 81255127741 scopus 로고    scopus 로고
    • Phase 2b randomized study of CPX-351 vs cytarabine (CYT)+daunorubicin (DNR) (7+3 regimen) in newly diagnosed AML patients aged 60-75
    • abstr 655
    • J.E. Lancet, J.E. Cortes, and D.E. Hogge Phase 2b randomized study of CPX-351 vs cytarabine (CYT)+daunorubicin (DNR) (7+3 regimen) in newly diagnosed AML patients aged 60-75 Blood (ASH Annual Meeting Abstracts) 116 2010 abstr 655
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116
    • Lancet, J.E.1    Cortes, J.E.2    Hogge, D.E.3
  • 17
    • 84889646919 scopus 로고    scopus 로고
    • Randomized phase 2 trial of timed-sequential therapy (TST) with flavopiridol (Alvocidib), Ara-C and mitoxantrone (FLAM) versus "7+3" for adults ages 70 years and under with newly diagnosed acute myeloid leukemia (AML)
    • abstr 47
    • J.F. Zeidner, J.M. Gerber, and A. Blackford Randomized phase 2 trial of timed-sequential therapy (TST) with flavopiridol (Alvocidib), Ara-C and mitoxantrone (FLAM) versus "7+3" for adults ages 70 years and under with newly diagnosed acute myeloid leukemia (AML) Blood (ASH Annual Meeting Abstracts) 120 2012 abstr 47
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Zeidner, J.F.1    Gerber, J.M.2    Blackford, A.3
  • 18
    • 79953124734 scopus 로고    scopus 로고
    • Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
    • M. Levis, F. Ravandi, and E.S. Wang Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse Blood 117 2011 3294 3301
    • (2011) Blood , vol.117 , pp. 3294-3301
    • Levis, M.1    Ravandi, F.2    Wang, E.S.3
  • 19
    • 84875592100 scopus 로고    scopus 로고
    • Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients >60 years of age with FLT3 ITD positive or negative relapsed/refractory acute myeloid leukemia
    • abstr 48
    • J.E. Cortes, A.E. Perl, and H. Dombret Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients >60 years of age with FLT3 ITD positive or negative relapsed/refractory acute myeloid leukemia Blood (ASH Annual Meeting Abstracts) 120 2012 abstr 48
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Cortes, J.E.1    Perl, A.E.2    Dombret, H.3
  • 20
    • 84875635430 scopus 로고    scopus 로고
    • Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia after second-line chemotherapy or hematopoietic stem cell transplantation
    • abstr 673
    • M.J. Levis, A.E. Perl, and H. Dombret Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia after second-line chemotherapy or hematopoietic stem cell transplantation Blood (ASH Annual Meeting Abstracts) 120 2012 abstr 673
    • (2012) Blood (ASH Annual Meeting Abstracts) , vol.120
    • Levis, M.J.1    Perl, A.E.2    Dombret, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.