Next-gen sequencing exposes frequent MED12 mutations and actionable therapeutic targets in phyllodes tumors

Molecular Cancer Research

Volumn 13, Issue 4, 2015, Pages 613-619

  Cani, Andi K ^a   Hovelson, Daniel H ^a   McDaniel, Andrew S ^a   Sadis, Seth ^b   Haller, Michaela J ^a   Yadati, Venkata ^a   Amin, Anmol M ^a   Bratley, Jarred ^a   Bandla, Santhoshi ^b   Williams, Paul D ^b   Rhodes, Kate ^b   Liu, Chia Jen ^a   Quist, Michael J ^a,c   Rhodes, Daniel R ^b   Grasso, Catherine S ^a,c   Kleer, Celina G ^a   Tomlins, Scott A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b Thermo Fisher Scientific   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; MEDIATOR COMPLEX; MEDIATOR COMPLEX SUBUNIT 12; NEUROFIBROMIN; PROTEIN P53; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; EGFR PROTEIN, HUMAN; IGF1R PROTEIN, HUMAN; MED12 PROTEIN, HUMAN; RETINOBLASTOMA PROTEIN; SOMATOMEDIN RECEPTOR; TP53 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER GRADING; CONTROLLED STUDY; COPY NUMBER VARIATION; CYSTOSARCOMA PHYLLOIDES; GENE AMPLIFICATION; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LOSS OF FUNCTION MUTATION; MIDDLE AGED; NEXT GENERATION SEQUENCING; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; YOUNG ADULT; BREAST TUMOR; DNA SEQUENCE; FEMALE; GENETICS; HIGH THROUGHPUT SEQUENCING; MUTATION; PATHOLOGY; PHYLLODES TUMOR; PROCEDURES;

BREAST NEOPLASMS; DNA COPY NUMBER VARIATIONS; FEMALE; GENE AMPLIFICATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MEDIATOR COMPLEX; MUTATION; NEUROFIBROMIN 1; PHYLLODES TUMOR; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, SOMATOMEDIN; RETINOBLASTOMA PROTEIN; SEQUENCE ANALYSIS, DNA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84928010286     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-14-0578     Document Type: Article

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