In vivo intracerebral administration of L-2-hydroxyglutaric acid provokes oxidative stress and histopathological alterations in striatum and cerebellum of adolescent rats

Free Radical Biology and Medicine

Volumn 83, Issue , 2015, Pages 201-213

  Da Rosa, Mateus Struecker ^a   João Ribeiro, César Augusto ^a   Seminotti, Bianca ^a   Teixeira Ribeiro, Rafael ^a   Umpierrez Amaral, Alexandre ^a   De Moura Coelho, Daniella ^b   De Oliveira, Francine Hehn ^b   Leipnitz, Guilhian ^a   Wajner, Moacir ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

Cerebellum; Histological analysis; L 2 Hydroxyglutaric acid; L 2 Hydroxyglutaric aciduria; Oxidative stress; Striatum

Indexed keywords

2 HYDROXYGLUTARIC ACID; ALPHA TOCOPHEROL; ALPHA TOCOPHEROL PLUS ASCORBIC ACID; ASCORBIC ACID; CATALASE; CREATINE; DICHLOROFLUORESCEIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MALONALDEHYDE; MELATONIN; OXIDOREDUCTASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; ALPHA-HYDROXYGLUTARATE; ANTIOXIDANT; GLUTARIC ACID DERIVATIVE;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN NECROSIS; CELL INFILTRATION; CELL VACUOLE; CEREBELLUM; CEREBELLUM INJURY; CONTROLLED STUDY; CORPUS STRIATUM; ENERGY METABOLISM; ENZYME ACTIVITY; EOSINOPHILIC GRANULOMA; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIPID OXIDATION; LIPID PEROXIDATION; LYMPHOCYTIC INFILTRATION; MACROPHAGE; METABOLITE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STAINING; STRIATAL DAMAGE; ANIMAL; DRUG ADMINISTRATION ROUTE; DRUG EFFECTS; ENZYME IMMUNOASSAY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; NEOSTRIATUM; PATHOLOGY; WESTERN BLOTTING;

RATTUS;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; CEREBELLUM; CORPUS STRIATUM; DRUG ADMINISTRATION ROUTES; GLUTARATES; GLUTATHIONE; IMMUNOENZYME TECHNIQUES; INFUSIONS, INTRAVENTRICULAR; LIPID PEROXIDATION; MALONDIALDEHYDE; NEOSTRIATUM; OXIDATIVE STRESS; RATS;

EID: 84927942090     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.02.008     Document Type: Article

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