T-cells and excitotoxicity: HIV-1 and other neurodegenerative disorders

NeuroMolecular Medicine

Volumn 7, Issue 3, 2005, Pages 265-273

  Mukhtar, Muhammad ^a   Acheampong, Edward ^a   Parveen, Zahida ^a   Pomerantz, Roger J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Central nervous system; Excitotoxicity; Glutamate; N methyl D asparate (NMDA); Neurodegeneration

Indexed keywords

AMINO ACID; CD4 ANTIGEN; GLUTAMIC ACID; KAINIC ACID; KAINIC ACID RECEPTOR; NEUROTRANSMITTER;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; BLOOD BRAIN BARRIER; CELL FUNCTION; CENTRAL NERVOUS SYSTEM; DEGENERATIVE DISEASE; EXCITOTOXICITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE FUNCTION TEST; IMMUNITY; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; MULTIPLE SCLEROSIS; NERVE DEGENERATION; NEUROTRANSMISSION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; TISSUE LEVEL;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 27144438693     PISSN: 15351084     EISSN: None     Source Type: Journal    
DOI: 10.1385/NMM:7:3:265     Document Type: Review

References (71)

1. Acheampong E., Mukhtar M., Parveen Z., et al. (2002) Ethanol strongly potentiates apoptosis induced by HIV-1 proteins in primary human brain microvascular endothelial cells. Virology 304, 222-234.
2. Adams C. L., Kobets N., Meiklejohn G. R., et al. (2004) Tracking lymphocytes in vivo. Arch. Immunol. Ther. Exp. (Warsz). 52, 173-187.
3. Barkhof F. (2004) Enlarged Virchow-Robin spaces: do they matter? J. Neurol. Neurosurg. Psychiatry 75, 1516-1517.
4. Beghi E. and Mennini T. (2004) Basic and clinical research on amyotrophic lateral sclerosis and other motor neuron disorders in Italy: recent findings and achievements from a network of laboratories. Neurol. Sci. 25, S41-S60.
5. Bendel O., Meijer B., Hurd Y., and von Euler G. (2005) Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus. Neurosci. Lett. 377, 31-36.
6. Benveniste H., Drejer J., Schousboe A., and Diemer N. H. (1984) Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43, 1369-1374.
7. Berczi I., Chalmers I. M., Nagy E., and Warrington R. J. (1996) The immune effects of neuropeptides. Baillieres Clin. Rheumatol. 10, 227-257.
8. Berger J. R. and Avison M. (2004) The blood brain barrier in HIV infection. Front Biosci. 9, 2680-2685.
9. Bonanno G., Giambelli R., Raiteri L., et al. (2005) Chronic antidepressants reduce depolarization-evoked glutamate release and protein interactions favoring formation of SNARE complex in hippocampus. J. Neurosci. 25, 3270-3279.
10. Bonvento G., Sibson N., and Pellerin L. (2002) Does glutamate image your thoughts? Trends Neurosci. 25, 359-364.
11. Buntinx M., Stinissen P., Steels P., Ameloot M., and Raus J. (2002) Immune-mediated oligodendrocyte injury in multiple sclerosis: molecular mechanisms and therapeutic interventions. Crit. Rev. Immunol. 22, 391-424.
12. Cabarrocas J., Bauer J., Piaggio E., Liblau R., and Lassmann H. (2003) Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes. Eur. J. Immunol. 33, 1174-1182.
13. Carrithers M. D., Visintin I., Viret C., and Janeway C. S. Jr. (2002) Role of genetic background in P selectin-dependent immune surveillance of the central nervous system. J. Neuroimmunol. 129, 51-57.
14. Chatterton J. E., Awobuluyi M., Premkumar L. S., et al. (2002) Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature 415, 793-798.
15. Chen W., Tang Z., Fortina P., et al. (2005) Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways. Virology 334, 59-73.
16. Chen Z., Yu S., Concha H. Q., et al. (2004) Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T-cell subsets may contribute differently to the pathogenesis. Brain Behav. Immun. 18, 175-185.
17. Cheng X., Mukhtar M., Acheampong E., et al. (2005) HIV-1 Vpr potently induces programmed cell death in the CNS in vivo, submitted.
18. Collard C. D., Park K. A., Montalto M. C., et al. (2002) Neutrophil-derived glutamate regulates vascular endothelial barrier function. J. Biol. Chem. 277, 14,801-14,811.
19. Drescher K. M., Johnston S. L., Hogancamp W., et al. (2000) V(beta)8(+) T-cells protect from demyelinating disease in a viral model of multiple sclerosis. Int. Immunol. 12, 271-280.
20. Eck H. P., Frey H., and Droge W. (1989) Elevated plasma glutamate concentrations in HIV-1-infected patients may contribute to loss of macrophage and lymphocyte functions. Int. Immunol. 1, 367-372.
21. Eck H. P., Mertens T., Rosokat H., et al. (1992) T4+ cell numbers are correlated with plasma glutamate and cystine levels: association of hyperglutamataemia with immunodeficiency in diseases with different aetiologies. Int. Immunol. 4, 7-13.
22. Epstein L. G. and Gelbard H. A. (1999) HIV-1-induced neuronal injury in the developing brain. J. Leukoc. Biol. 65, 453-457.
23. Erecinska M., Zaleska M. M., Nelson D., Nissim I., and Yudkoff M. (1990) Neuronal glutamine utilization: glutamine/glutamate homeostasis in synaptosomes. J. Neurochem. 54, 2057-2069.
24. Ferrarese C., Aliprandi A., Tremolizzo L., Stanzani L., De Micheli A., Dolara A., et al. (2001) Increased glutamate in CSF and plasma of patients with HIV dementia. Neurology 57, 671-675.
25. Ganor Y., Besser M., Ben-Zakay N., Unger T., and Levite M. (2003) Human T-cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration. J. Immunol. 170, 4362-4372.
26. Gardian G. and Vecsei L. (2004) Huntington's disease: pathomechanism and therapeutic perspectives. J. Neural. Transm. 111, 1485-1494.
27. Gottlieb M., Wang Y., and Teichberg V. I. (2003) Blood-mediated scavenging of cerebrospinal fluid glutamate. J. Neurochem. 87, 119-126.
28. Haughey N. J. and Mattson M. P. (2002) Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120. J. Acquir. Immune. Defic. Syndr. 31, S55-S61.
29. Haughey N. J., Nath A., Mattson M. P., Slevin J. T., and Geiger J. D. (2001) HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. J. Neurochem. 78, 457-467.
30. Hemmer B., Cepok S., Nessler S., and Sommer N. (2002) Pathogenesis of multiple sclerosis: an update on immunology. Curr. Opin. Neurol. 15, 227-231.
31. Hertz L., Dringen R., Schousboe A., and Robinson S. R. (1999) Astrocytes: glutamate producers for neurons. J. Neurosci. Res. 57, 417-428.
32. Hickey W. F., Hsu B. L., and Kimura H. (1991) T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28, 254-260.
33. Holm G. H. and Gabuzda D. (2005) Distinct mechanisms of CD4+ and CD8+ T-cell activation and bystander apoptosis induced by human immunodeficiency virus type 1 virions. J. Virol. 79, 6299-6311.
34. Kerfoot S. M. and Kubes P. (2002) Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis. J. Immunol. 169, 1000-1006.
35. Koller W. C. and Cersosimo M. G. (2004) Neuroprotection in Parkinson's disease: an elusive goal. Curr. Neurol. Neurosci. Rep. 4, 277-283.
36. Kustova Y., Grinberg A., and Basile A. S. (1999) Increased blood-brain barrier permeability in LP-BM5 infected mice is mediated by neuroexcitatory mechanisms. Brain Res. 839, 153-163.
37. Kuznetsova S. A. and Roberts D. D. (2004) Functional regulation of T lymphocytes by modulatory extracellular matrix proteins. Int. J. Biochem. Cell. Biol. 36, 1126-1134.
38. Kvamme E., Schousboe A., Hertz L., Torgner I. A., and Svenneby G. (1985) Developmental change of endogenous glutamate and gamma-glutamyl transf erase in cultured cerebral cortical interneurons and cerebellar granule cells, and in mouse cerebral cortex and cerebellum in vivo. Neurochem. Res. 10, 993-1008.
39. Lipton S. A. and Rosenberg P. A. (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613-622.
40. Lombardi G., Miglio G., Canonico P. L., Naldi P., Comi C., and Monaco F. (2003) Abnormal response to glutamate of T lymphocytes from multiple sclerosis patients. Neurosci. Lett. 340, 5-8.
41. Lynn W. S. and Wong P. K. (1995) Neuroimmunodegeneration: do neurons and T cells use common pathways for cell death? FASEB J. 9, 1147-1156.
42. Mattson M. P., Haughey N. J., and Nath A. (2005) Cell death in HIV dementia. Cell Death Differ. 1-12
43. Milicevic N. M., Nohroudi K., Milicevic Z., and Westermann J. (2004) Blood lymphocytes, monocytes and NK cells modulate their expression of CD44, ICAM-1, LFA-1 and MHC class II after arrival into lymphoid organs. Immunol. Invest. 33, 439-452.
44. Mintz M. (1994) Clinical comparison of adult and pediatric NeuroAIDS. Adv. Neuroimmunol. 4, 207-221.
45. Moalem G., Leibowitz-Amit R., Yoles E., Mor F., Cohen I. R., and Schwartz M. (1999) Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat. Med. 5, 49-55.
46. Mukhtar M., Mengistu A., Acheampong E., et al. (2003) Statins block enhanced expression of matrix metalloproteinases (MMPs) by virally infected monocytes and T-cells and thereby normalize their transvascular transmigration. A novel therapeutic approach to HIV-1 neuroinvasion. Circulation 108, 487.
47. Nishino H., Hida H., Kumazaki M., et al. (2000) The striatum is the most vulnerable region in the brain to mitochondrial energy compromise: a hypothesis to explain its specific vulnerability. J. Neurotrauma 17, 251-260.
48. Noseworthy J. H., Lucchinetti C., Rodriguez M., and Weinshenker B. G. (2000) Multiple sclerosis. N. Engl. J. Med. 343, 938-952.
49. Olney J. W. (2003) Excitotoxicity, apoptosis and neuropsychiatric disorders. Curr. Opin. Pharmacol. 3, 101-109.
50. Patel C. A., Mukhtar M., Harley S., Kulkosky J., and Pomerantz R. J. (2002) Lentiviral expression of HIV-1 Vpr induces apoptosis in human neurons. J. Neurovirol. 8, 86-99.
51. Petito C. K. and Adkins B. (2005) Choroid plexus selectively accumulates T-lymphocytes in normal controls and after peripheral immune activation. J. Neuroimmunol. 162, 19-27.
52. Raman C., McAllister S. D., Rizvi G., Patel S. G., Moore D. H., and Abood M. E. (2004) Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 5, 33-39.
53. Ringheim G. E. and Conant K. (2004) Neurodegenerative disease and the neuroimmune axis (Alzheimer's and Parkinson's disease, and viral infections). J. Neuroimmunol. 147, 43-49.
54. Rothstein J. D., Martin L., Levey A. I., et al. (1994) Localization of neuronal and glial glutamate transporters. Neuron 13, 713-725.
55. Sanchez-Ramon S., Bellon J. M., Resino S., et al. (2003) Low blood CD8+ T-lymphocytes and high circulating monocytes are predictors of HIV-1-associated progressive encephalopathy in children. Pediatrics 111, E168-E175.
56. Schousboe A., Westergaard N., Sonnewald U., et al. (1993) Glutamate and glutamine metabolism and compartmentation in astrocytes. Dev. Neurosci. 15, 359-366.
57. Shacklett B. L., Cox C. A., Wilkens D. T., et al. (2004) Increased adhesion molecule and chemokine receptor expression on CD8+ T cells trafficking to cerebrospinal fluid in HIV-1 infection. J. Infect. Dis. 189, 2202-2212.
58. Sharp C. D., Hines I., Houghton J., et al. (2003) Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor. Am. J. Physiol. Heart Circ. Physiol. 285, H2592-H2598.
59. Srinivasan R., Sailasuta N., Hurd R., Nelson S., and Pelletier D. (2005) Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T. Brain 128, 1016-1025.
60. Stoica G., Floyd E., Illanes O., and Wong P. K. (1992) Temporal lymphoreticular changes caused by ts1, a paralytogenic mutant of Moloney murine leukemia virus TB. Lab. Invest. 66, 427-436.
61. Svenningsson A., Andersen O., Edsbagge M., and Stemme S. (1995) Lymphocyte phenotype and subset distribution in normal cerebrospinal fluid. J. Neuroimmunol. 63, 39-46.
62. Swift M., Heim R. A., and Lench N. J. (1993) Genetic aspects of ataxia telangiectasia. Adv. Neurol. 61, 115-125.
63. Tovar K. R. and Westbrook G. L. (1999) The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J. Neurosci. 19, 4180-4188.
64. Tovar K. R. and Westbrook G. L. (2002) Mobile NMDA receptors at hippocampal synapses. Neuron 34, 255-264.
65. Vargas D. L., Nascimbene C., Krishnan C., Zimmerman A. W., and Pardo C. A. (2005) Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 57, 67-81.
66. Wang Z., Pekarskaya O., Bencheikh M., et al. (2003) Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. Virology 312, 60-73.
67. Weiner H. L. (2004) Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease. Arch. Neurol. 61, 1613-1615.
68. Wolf S. A., Fisher J., Bechmann I., Steiner B., Kwidzinski E., and Nitsch R. (2002) Neuroprotection by T-cells depends on their subtype and activation state. J. Neuroimmunol. 133, 72-80.
69. Wong D., Prameya R., and Dorovini-Zis K. (1999) In vitro adhesion and migration of T lymphocytes across monolayers of human brain microvessel endothelial cells: regulation by ICAM-1, VCAM-1, E-selectin and PECAM-1. J. Neuropathol. Exp. Neurol. 58, 138-152.
70. Xu Y., Kulkosky J., Acheampong E., Nunnari G., Sullivan J., and Pomerantz R. J. (2004) HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy. Proc. Natl. Acad. Sci. USA 101, 7070-7075.
71. Zeron M. M., Fernandes H. B., Krebs C., et al. (2004) Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease. Mol. Cell Neurosci. 25, 469-479.