Autophagic Markers BECLIN 1 and LC3 Are Associated with Prognosis of Multiple Myeloma

Acta Haematologica

Volumn 134, Issue 1, 2015, Pages 17-24

  Jung, Geunyoung ^a   Roh, Jin ^a   Lee, Hyangsin ^a,d   Gil, Minchan ^a,d   Yoon, Doc Hyun ^c   Suh, Cheolwon ^c   Jang, Seongsoo ^b   Park, Chan Jeoung ^b   Huh, Jooryung ^a   Park, Chan Sik ^a,d  

^a University of Ulsan College of Medicine   (South Korea)

^b Departments of Dermatology   (South Korea)

^c Departments of Oncology   (South Korea)

^d Asan Institute for Life Sciences   (South Korea)

Author keywords

BECLIN 1; Immunohistochemistry; Microtubule associated protein light chain 3; Multiple myeloma; Prognosis

Indexed keywords

BECLIN 1; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3; TUMOR MARKER; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; LIGHT CHAIN 3, HUMAN; MEMBRANE PROTEIN; TUMOR PROTEIN;

ADULT; AGED; ARTICLE; AUTOPHAGY; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURVIVAL; CLINICAL FEATURE; COHORT ANALYSIS; CORRELATIONAL STUDY; DISEASE ASSOCIATION; DISEASE SPECIFIC SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INDEPENDENT VARIABLE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTIPLE MYELOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; TREATMENT OUTCOME; BIOSYNTHESIS; CLINICAL TRIAL; DISEASE FREE SURVIVAL; FOLLOW UP; GENE EXPRESSION REGULATION; METABOLISM; MORTALITY; PATHOLOGY; SURVIVAL RATE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MULTIPLE MYELOMA; NEOPLASM PROTEINS; RETROSPECTIVE STUDIES; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 84927930273     PISSN: 00015792     EISSN: 14219662     Source Type: Journal    
DOI: 10.1159/000368848     Document Type: Article

References (36)

1. Kapoor P, Rajkumar SV: Update on risk stratification and treatment of newly diagnosed multiple myeloma. Int J Hematol 2011; 94: 310-320.
2. Bergsagel PL, Kuehl WM: Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol 2005; 23: 6333-6338.
3. Fonseca R, Bergsagel PL, Drach J, Shaughnessy J, Gutierrez N, Stewart AK, Morgan G, Van Ness B, Chesi M, Minvielle S, Neri A, Barlogie B, Kuehl WM, Liebisch P, Davies F, Chen-Kiang S, Durie BG, Carrasco R, Sezer O, Reiman T, Pilarski L, Avet-Loiseau H: International myeloma working group molecular classification of multiple myeloma: spotlight review. Leukemia 2009; 23: 2210-2221.
4. Mathew R, Karantza-Wadsworth V, White E: Role of autophagy in cancer. Nat Rev Cancer 2007; 7: 961-967.
5. Tanida I: Autophagy basics. Microbiol Immunol 2011; 55: 1-11.
6. Singh R, Cuervo AM: Autophagy in the cellular energetic balance. Cell Metab 2011; 13: 495-504.
7. He C, Klionsky DJ: Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43: 67-93.
8. Sivridis E, Koukourakis MI, Mendrinos SE, Karpouzis A, Fiska A, Kouskoukis C, Giatromanolaki A: Beclin-1 and LC3A expression in cutaneous malignant melanomas: a biphasic survival pattern for beclin-1. Melanoma Res 2011; 21: 188-195.
9. Sivridis E, Koukourakis MI, Zois CE, Ledaki I, Ferguson DJ, Harris AL, Gatter KC, Giatromanolaki A: LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas. Am J Pathol 2010; 176: 2477-2489.
10. Li BX, Li CY, Peng RQ, Wu XJ, Wang HY, Wan DS, Zhu XF, Zhang XS: The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy 2009; 5: 303-306.
11. Zhou W, Yue C, Deng J, Hu R, Xu J, Feng L, Lan Q, Zhang W, Ji D, Wu J, Liu Q, Liu A: Autophagic protein beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer. PLoS One 2013; 8:e80338.
12. Nicotra G, Mercalli F, Peracchio C, Castino R, Follo C, Valente G, Isidoro C: Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas. Mod Pathol 2010; 23: 937-950.
13. Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E, Orfanelli U, Ponzoni M, Sitia R, Casola S, Cenci S: Plasma cells require autophagy for sustainable immunoglobulin production. Nat Immunol 2013; 14: 298-305.
14. Lamy L, Ngo VN, Emre NC, Shaffer AL 3rd, Yang Y, Tian E, Nair V, Kruhlak MJ, Zingone A, Landgren O, Staudt LM: Control of autophagic cell death by caspase-10 in multiple myeloma. Cancer Cell 2013; 23: 435-449.
15. Hoang B, Benavides A, Shi Y, Frost P, Lichtenstein A: Effect of autophagy on multiple myeloma cell viability. Mol Cancer Ther 2009; 8: 1974-1984.
16. Thirukkumaran CM, Shi ZQ, Luider J, Kopciuk K, Gao H, Bahlis N, Neri P, Pho M, Stewart D, Mansoor A, Morris DG: Reovirus modulates autophagy during oncolysis of multiple myeloma. Autophagy 2013; 9: 413-414.
17. Pan Y, Gao Y, Chen L, Gao G, Dong H, Yang Y, Dong B, Chen X: Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy. Clin Cancer Res 2011; 17: 3248-3258.
18. Huang JJ, Zhu YJ, Lin TY, Jiang WQ, Huang HQ, Li ZM: Beclin 1 expression predicts favorable clinical outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP. Hum Pathol 2011; 42: 1459-1466.
19. Choi J, Jung W, Koo JS: Expression of autophagy-related markers beclin-1, light chain 3a, light chain 3b and p62 according to the molecular subtype of breast cancer. Histopathology 2013; 62: 275-286.
20. Miracco C, Cosci E, Oliveri G, Luzi P, Pacenti L, Monciatti I, Mannucci S, De Nisi MC, Toscano M, Malagnino V, Falzarano SM, Pirtoli L, Tosi P: Protein and mRNA expression of autophagy gene beclin 1 in human brain tumours. Int J Oncol 2007; 30: 429-436.
21. Zhou WH, Tang F, Xu J, Wu X, Yang SB, Feng ZY, Ding YG, Wan XB, Guan Z, Li HG, Lin DJ, Shao CK, Liu Q: Low expression of Beclin 1, associated with high Bcl-xL, predicts a malignant phenotype and poor prognosis of gastric cancer. Autophagy 2012; 8: 389-400.
22. Chen Y, Lu Y, Lu C, Zhang L: Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression. Pathol Oncol Res 2009; 15: 487-493.
23. Kim HS, Lee SH, Do SI, Lim SJ, Park YK, Kim YW: Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma. Pathol Res Pract 2011; 207: 247-252.
24. Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B: Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402: 672-676.
25. Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM: Dram, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006; 126: 121-134.
26. Levine B, Kroemer G: Autophagy in the pathogenesis of disease. Cell 2008; 132: 27-42.
27. Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B: Bcl-2 antiapoptotic proteins inhibit beclin 1-dependent autophagy. Cell 2005; 122: 927-939.
28. Weiner LM, Lotze MT: Tumor-cell death, autophagy, and immunity. N Engl J Med 2012; 366: 1156-1158.
29. Michaud M, Martins I, Sukkurwala AQ, Adjemian S, Ma Y, Pellegatti P, Shen S, Kepp O, Scoazec M, Mignot G, Rello-Varona S, Tailler M, Menger L, Vacchelli E, Galluzzi L, Ghiringhelli F, di Virgilio F, Zitvogel L, Kroemer G: Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science 2011; 334: 1573-1577.
30. Rao S, Yang H, Penninger JM, Kroemer G: Autophagy in non-small cell lung carcinogenesis: a positive regulator of antitumor immunosurveillance. Autophagy 2014; 10: 529-531.
31. Wan XB, Fan XJ, Chen MY, Xiang J, Huang PY, Guo L, Wu XY, Xu J, Long ZJ, Zhao Y, Zhou WH, Mai HQ, Liu Q, Hong MH: Elevated beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy 2010; 6: 395-404.
32. Zhang Z, Shao Z, Xiong L, Che B, Deng C, Xu W: Expression of beclin1 in osteosarcoma and the effects of down-regulation of autophagy on the chemotherapeutic sensitivity. J Huazhong Univ Sci Technol Med Sci 2009; 29: 737-740.
33. Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, White E: Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007; 21: 1621-1635.
34. Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, Bray K, Reddy A, Bhanot G, Gelinas C, Dipaola RS, Karantza-Wadsworth V, White E: Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009; 137: 1062-1075.
35. Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, Tavare S, Arakawa S, Shimizu S, Watt FM: Autophagy mediates the mitotic senescence transition. Genes Dev 2009; 23: 798-803.
36. Elgendy M, Sheridan C, Brumatti G, Martin SJ: Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol Cell 2011; 42: 23-35.