Involvement of P2Y12 receptor in vascular smooth muscle inflammatory changes via MCP-1 upregulation and monocyte adhesion

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 308, Issue 8, 2015, Pages H853-H861

  Satonaka, Hiroshi ^a   Nagata, Daisuke ^a   Takahashi, Masao ^a   Kiyosue, Arihiro ^a   Myojo, Masahiro ^a   Fujita, Daishi ^a   Ishimitsu, Toshihiko ^c   Nagano, Tetsuo ^b   Nagai, Ryozo ^a   Hirata, Yasunobu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Atherosclerosis; Cytokines; Inflammation; Purinergic P2 receptors; Vascular smooth muscle cell

Indexed keywords

ALVESPIMYCIN; ANGIOTENSIN II; APOLIPOPROTEIN E; HEAT SHOCK PROTEIN 90; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; ADENOSINE DIPHOSPHATE; CCL2 PROTEIN, RAT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PURINERGIC P2Y RECEPTOR ANTAGONIST; PURINERGIC P2Y12 RECEPTOR; REACTIVE OXYGEN METABOLITE;

ABDOMINAL AORTA ANEURYSM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; INFLAMMATION; MALE; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; VASCULAR SMOOTH MUSCLE; ANIMAL; CELL ADHESION; CELL CULTURE; DRUG EFFECTS; GENETICS; METABOLISM; MONOCYTE; PATHOLOGY; PHYSIOLOGY; RAT; UPREGULATION; WISTAR RAT;

ADENOSINE DIPHOSPHATE; ANIMALS; CELL ADHESION; CELLS, CULTURED; CHEMOKINE CCL2; INFLAMMATION; MALE; MONOCYTES; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RECEPTORS, PURINERGIC P2Y12; RNA, MESSENGER; UP-REGULATION;

EID: 84927919837     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00862.2013     Document Type: Article

References (31)

1. Armstrong S, Korcok J, Sims SM, Dixon SJ. Activation of transcription factors by extracellular nucleotides in immune and related cell types. Purinergic Signal 3: 59-69, 2007.
2. Born GV, Kratzer MA. Source and concentration of extracellular adenosine triphosphate during haemostasis in rats, rabbits and man. J Physiol 354: 419-429, 1984.
3. Burnstock G, Knight GE. Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol 240: 31-304, 2004.
4. Burnstock G. Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol Rev 58: 58-86, 2006.
5. Chen L, Frister A, Wang S, Ludwig A, Behr H, Pippig S, Li B, Simm A, Hofmann B, Pilowski C, Koch S, Buerke M, Rose-John S, Werdan K, Loppnow H. Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production. Am J Physiol Heart Circ Physiol 296: H987-H996, 2009.
6. Chen YM, Chiang WC, Lin SL, Wu KD, Tsai TJ, Hsieh BS. Dual regulation of tumor necrosis factor-alpha-induced CCL2/monocyte chemoattractant protein-1 expression in vascular smooth muscle cells by nuclear factor-kappaB and activator protein-1: modulation by type III phosphodiesterase inhibition. J Pharmacol Exp Ther 309: 978-986, 2004.
7. Crowley ST, Dempsey EC, Horwitz KB, Horwitz LD. Platelet-induced vascular smooth muscle cell proliferation is modulated by the growth amplification factors serotonin and adenosine diphosphate. Circulation 90: 1908-1918, 1994.
8. da Silva CG, Specht A, Wegiel B, Ferran C, Kaczmarek E. Mechanism of purinergic activation of endothelial nitric oxide synthase in endothelial cells. Circulation 119: 871-879, 2009.
9. De Keulenaer GW, Ushio-Fukai M, Yin Q, Chung AB, Lyons PR, Ishizaka N, Rengarajan K, Taylor WR, Alexander RW, Griendling KK. Convergence of redox-sensitive and mitogen-activated protein kinase signaling pathways in tumor necrosis factor-alpha-mediated monocyte chemoattractant protein-1 induction in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 20: 385-391, 2000.
10. Di Virgilio F. Purinergic mechanism in the immune system: a signal of danger for dendritic cells. Purinergic Signal 1: 205-209, 2005.
11. Erlinge D, Burnstock G. P2 receptors in cardiovascular regulation and disease. Purinergic Signal 4: 1-20, 2008.
12. Erlinge D, Hou M, Webb TE, Barnard EA, Möller S. Phenotype changes of the vascular smooth muscle cell regulate P2 receptor expression as measured by quantitative RT-PCR. Biochem Biophys Res Commun 248: 864-870, 1998.
13. Frenette PS, Johnson RC, Hynes RO, Wagner DD. Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Proc Natl Acad Sci USA 92: 7450-7454, 1995.
14. Gachet C. The platelet P2 receptors as molecular targets for old and new antiplatelet drugs. Pharmacol Ther 108: 180-192, 2005.
15. Garrido AM, Griendling KK. NADPH oxidases and angiotensin II receptor signaling. Mol Cell Endocrinol 302: 148-158, 2009.
16. Govindan S, Taylor EJ, Taylor CW. Ca(2+) signalling by P2Y receptors in cultured rat aortic smooth muscle cells. Br J Pharmacol 160: 1953-1962, 2010.
17. Guns PJ, Korda A, Crauwels HM, Van Assche T, Robaye B, Boeynaems JM, Bult H. Pharmacological characterization of nucleotide P2Y receptors on endothelial cells of the mouse aorta. Br J Pharmacol 146: 288-295, 2005.
18. Hasegawa M, Sugidachi A, Ogawa T, Isobe T, Jakubowski JA, Asai F. Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor. Thromb Haemost 94: 593-598, 2005.
19. Hechler B, Freund M, Ravanat C, Magnenat S, Cazenave JP, Gachet C. Reduced atherosclerotic lesions in P2Y1/apolipoprotein E doubleknockout mice: the contribution of non-hematopoietic-derived P2Y1 receptors. Circulation 118: 754-763, 2008.
20. Huo Y, Schober A, Forlow SB, Smith DF, Hyman MC, Jung S, Littman DR, Weber C, Ley K. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 9: 61-67, 2003.
21. Koziak K, Bojakowska M, Robson SC, Bojakowski K, Soin J, Csizmadia E, Religa P, Gaciong Z, Kaczmarek E. Overexpression of CD39/nucleoside triphosphate diphosphohydrolase-1 decreases smooth muscle cell proliferation and prevents neointima formation after angioplasty. J Thromb Haemost 6: 1191-1197, 2008.
22. Larsen E, Celi A, Gilbert GE, Furie BC, Erban JK, Bonfanti R, Wagner DD, Furie B. PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell 59: 305-312, 1989.
23. Meng L, Park J, Cai Q, Lanting L, Reddy MA, Natarajan R. Diabetic conditions promote binding of monocytes to vascular smooth muscle cells and their subsequent differentiation. Am J Physiol Heart Circ Physiol 298: H736-H745, 2010.
24. Rauch BH, Rosenkranz AC, Ermler S, Bohm A, Driessen J, Fischer JW, Sugidachi A, Jakubowski JA, Schror K. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol 30: 2434-2442, 2010.
25. Ross R. The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. J Cell Biol 50: 172-186, 1971.
26. Schober A. Chemokines in vascular dysfunction and remodeling. Arterioscler Thromb Vasc Biol 28: 1950-1959, 2008.
27. Shen J, DiCorleto PE. ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways. Circ Res 102: 448-456, 2008.
28. Valentine N, Van de Laar FA, van Driel ML. Adenosine-diphosphate (ADP) receptor antagonists for the prevention of cardiovascular disease in type 2 diabetes mellitus. Cochrane Database Syst Rev 11: CD005449, 2012.
29. von Hundelshausen P, Weber C. Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res 100: 27-40, 2007.
30. Wihlborg AK, Wang L, Braun OO, Eyjolfsson A, Gustafsson R, Gudbjartsson T, Erlinge D. ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels. Arterioscler Thromb Vasc Biol 24: 1810-1815, 2004.
31. Xing D, Feng W, Miller AP, Weathington NM, Chen YF, Novak L, Blalock JE, Oparil S. Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptorbeta activation. Am J Physiol Heart Circ Physiol 292: H2607-H2612, 2007.