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Volumn 17, Issue 5, 2015, Pages 607-620

Fusion of Legionella pneumophila outer membrane vesicles with eukaryotic membrane systems is a mechanism to deliver pathogen factors to host cell membranes

Author keywords

[No Author keywords available]

Indexed keywords

LIPOSOME; PHOSPHOLIPID; TOLL LIKE RECEPTOR 4; TRYPAN BLUE; TUMOR NECROSIS FACTOR ALPHA; VIRULENCE FACTOR;

EID: 84927800581     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/cmi.12392     Document Type: Article
Times cited : (86)

References (42)
  • 1
    • 11144338200 scopus 로고    scopus 로고
    • Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila
    • Akamine, M., Higa, F., Arakaki, N., Kawakami, K., Takeda, K., Akira, S., and Saito, A. (2005) Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila. Infect Immun 73: 352-361.
    • (2005) Infect Immun , vol.73 , pp. 352-361
    • Akamine, M.1    Higa, F.2    Arakaki, N.3    Kawakami, K.4    Takeda, K.5    Akira, S.6    Saito, A.7
  • 2
    • 62449308947 scopus 로고    scopus 로고
    • Vesicular stabilization and activity augmentation of enterohaemorrhagic Escherichia coli haemolysin
    • Aldick, T., Bielaszewska, M., Uhlin, B.E., Humpf, H.U., Wai, S.N., and Karch, H. (2009) Vesicular stabilization and activity augmentation of enterohaemorrhagic Escherichia coli haemolysin. Mol Microbiol 71: 1496-1508.
    • (2009) Mol Microbiol , vol.71 , pp. 1496-1508
    • Aldick, T.1    Bielaszewska, M.2    Uhlin, B.E.3    Humpf, H.U.4    Wai, S.N.5    Karch, H.6
  • 3
    • 84872352440 scopus 로고    scopus 로고
    • Role of phospholipids in endocytosis, phagocytosis, and macropinocytosis
    • Bohdanowicz, M., and Grinstein, S. (2013) Role of phospholipids in endocytosis, phagocytosis, and macropinocytosis. Physiol Rev 93: 69-106.
    • (2013) Physiol Rev , vol.93 , pp. 69-106
    • Bohdanowicz, M.1    Grinstein, S.2
  • 4
    • 66349107694 scopus 로고    scopus 로고
    • Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles
    • Bomberger, J.M., Maceachran, D.P., Coutermarsh, B.A., Ye, S., O'Toole, G.A., and Stanton, B.A. (2009) Long-distance delivery of bacterial virulence factors by Pseudomonas aeruginosa outer membrane vesicles. PLoS Pathog 5: e1000382.
    • (2009) PLoS Pathog , vol.5 , pp. e1000382
    • Bomberger, J.M.1    Maceachran, D.P.2    Coutermarsh, B.A.3    Ye, S.4    O'Toole, G.A.5    Stanton, B.A.6
  • 5
    • 0030712478 scopus 로고    scopus 로고
    • Conformational studies of synthetic lipid A analogues and partial structures by infrared spectroscopy
    • Brandenburg, K., Kusumoto, S., and Seydel, U. (1997) Conformational studies of synthetic lipid A analogues and partial structures by infrared spectroscopy. Biochim Biophys Acta 1329: 183-201.
    • (1997) Biochim Biophys Acta , vol.1329 , pp. 183-201
    • Brandenburg, K.1    Kusumoto, S.2    Seydel, U.3
  • 6
    • 0344043304 scopus 로고    scopus 로고
    • Characterization of the nonlamellar cubic and HII structures of lipid A from Salmonella enterica serovar Minnesota by X-ray diffraction and freeze-fracture electron microscopy
    • Brandenburg, K., Richter, W., Koch, M.H., Meyer, H.W., and Seydel, U. (1998) Characterization of the nonlamellar cubic and HII structures of lipid A from Salmonella enterica serovar Minnesota by X-ray diffraction and freeze-fracture electron microscopy. Chem Phys Lipids 91: 53-69.
    • (1998) Chem Phys Lipids , vol.91 , pp. 53-69
    • Brandenburg, K.1    Richter, W.2    Koch, M.H.3    Meyer, H.W.4    Seydel, U.5
  • 7
    • 0033572533 scopus 로고    scopus 로고
    • Investigation into the acyl chain packing of endotoxins and phospholipids under near physiological conditions by WAXS and FTIR spectroscopy
    • Brandenburg, K., Funari, S.S., Koch, M.H., and Seydel, U. (1999) Investigation into the acyl chain packing of endotoxins and phospholipids under near physiological conditions by WAXS and FTIR spectroscopy. J Struct Biol 128: 175-186.
    • (1999) J Struct Biol , vol.128 , pp. 175-186
    • Brandenburg, K.1    Funari, S.S.2    Koch, M.H.3    Seydel, U.4
  • 8
    • 11044225951 scopus 로고    scopus 로고
    • Expression of IL-6 and TNF-alpha in human alveolar epithelial cells is induced by invading, but not by adhering, Legionella pneumophila
    • Chang, B., Amemura-Maekawa, J., Kura, F., Kawamura, I., and Watanabe, H. (2004) Expression of IL-6 and TNF-alpha in human alveolar epithelial cells is induced by invading, but not by adhering, Legionella pneumophila. Microb Pathog 37: 295-302.
    • (2004) Microb Pathog , vol.37 , pp. 295-302
    • Chang, B.1    Amemura-Maekawa, J.2    Kura, F.3    Kawamura, I.4    Watanabe, H.5
  • 9
    • 77749309281 scopus 로고    scopus 로고
    • Virulence and immunomodulatory roles of bacterial outer membrane vesicles
    • Ellis, T.N., and Kuehn, M.J. (2010) Virulence and immunomodulatory roles of bacterial outer membrane vesicles. Microbiol Mol Biol Rev 74: 81-94.
    • (2010) Microbiol Mol Biol Rev , vol.74 , pp. 81-94
    • Ellis, T.N.1    Kuehn, M.J.2
  • 10
    • 4344618967 scopus 로고    scopus 로고
    • Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2
    • Erridge, C., Pridmore, A., Eley, A., Stewart, J., and Poxton, I.R. (2004) Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2. J Med Microbiol 53: 735-740.
    • (2004) J Med Microbiol , vol.53 , pp. 735-740
    • Erridge, C.1    Pridmore, A.2    Eley, A.3    Stewart, J.4    Poxton, I.R.5
  • 11
    • 33646918848 scopus 로고    scopus 로고
    • Membrane vesicles shed by Legionella pneumophila inhibit fusion of phagosomes with lysosomes
    • Fernandez-Moreira, E., Helbig, J.H., and Swanson, M.S. (2006) Membrane vesicles shed by Legionella pneumophila inhibit fusion of phagosomes with lysosomes. Infect Immun 74: 3285-3295.
    • (2006) Infect Immun , vol.74 , pp. 3285-3295
    • Fernandez-Moreira, E.1    Helbig, J.H.2    Swanson, M.S.3
  • 12
    • 0018361809 scopus 로고
    • Preparation and properties of a standardized lipopolysaccharide from salmonella abortus equi (Novo-Pyrexal)
    • Galanos, C., Luderitz, O., and Westphal, O. (1979) Preparation and properties of a standardized lipopolysaccharide from salmonella abortus equi (Novo-Pyrexal). Zentralbl Bakteriol [Orig A] 243: 226-244.
    • (1979) Zentralbl Bakteriol [Orig A] , vol.243 , pp. 226-244
    • Galanos, C.1    Luderitz, O.2    Westphal, O.3
  • 13
    • 42949174067 scopus 로고    scopus 로고
    • Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesicles
    • Galka, F., Wai, S.N., Kusch, H., Engelmann, S., Hecker, M., Schmeck, B., etal. (2008) Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesicles. Infect Immun 76: 1825-1836.
    • (2008) Infect Immun , vol.76 , pp. 1825-1836
    • Galka, F.1    Wai, S.N.2    Kusch, H.3    Engelmann, S.4    Hecker, M.5    Schmeck, B.6
  • 14
    • 81355138899 scopus 로고    scopus 로고
    • Manipulation of host vesicular trafficking and innate immune defence by Legionella Dot/Icm effectors
    • Ge, J., and Shao, F. (2011) Manipulation of host vesicular trafficking and innate immune defence by Legionella Dot/Icm effectors. Cell Microbiol 13: 1870-1880.
    • (2011) Cell Microbiol , vol.13 , pp. 1870-1880
    • Ge, J.1    Shao, F.2
  • 15
    • 0037439663 scopus 로고    scopus 로고
    • Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2
    • Girard, R., Pedron, T., Uematsu, S., Balloy, V., Chignard, M., Akira, S., and Chaby, R. (2003) Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J Cell Sci 116: 293-302.
    • (2003) J Cell Sci , vol.116 , pp. 293-302
    • Girard, R.1    Pedron, T.2    Uematsu, S.3    Balloy, V.4    Chignard, M.5    Akira, S.6    Chaby, R.7
  • 16
    • 0034773027 scopus 로고    scopus 로고
    • Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells
    • Gutsmann, T., Muller, M., Carroll, S.F., MacKenzie, R.C., Wiese, A., and Seydel, U. (2001) Dual role of lipopolysaccharide (LPS)-binding protein in neutralization of LPS and enhancement of LPS-induced activation of mononuclear cells. Infect Immun 69: 6942-6950.
    • (2001) Infect Immun , vol.69 , pp. 6942-6950
    • Gutsmann, T.1    Muller, M.2    Carroll, S.F.3    MacKenzie, R.C.4    Wiese, A.5    Seydel, U.6
  • 17
    • 0035135102 scopus 로고    scopus 로고
    • Immunolocalization of the Mip protein of intracellularly and extracellularly grown Legionella pneumophila
    • Helbig, J.H., Luck, P.C., Steinert, M., Jacobs, E., and Witt, M. (2001) Immunolocalization of the Mip protein of intracellularly and extracellularly grown Legionella pneumophila. Lett Appl Microbiol 32: 83-88.
    • (2001) Lett Appl Microbiol , vol.32 , pp. 83-88
    • Helbig, J.H.1    Luck, P.C.2    Steinert, M.3    Jacobs, E.4    Witt, M.5
  • 18
    • 78049370513 scopus 로고    scopus 로고
    • Modulation of host cell function by Legionella pneumophila type IV effectors
    • Hubber, A., and Roy, C.R. (2010) Modulation of host cell function by Legionella pneumophila type IV effectors. Annu Rev Cell Dev Biol 26: 261-283.
    • (2010) Annu Rev Cell Dev Biol , vol.26 , pp. 261-283
    • Hubber, A.1    Roy, C.R.2
  • 19
    • 84899552987 scopus 로고    scopus 로고
    • Master manipulators: an update on Legionella pneumophila Icm/Dot translocated substrates and their host targets
    • Isaac, D.T., and Isberg, R. (2014) Master manipulators: an update on Legionella pneumophila Icm/Dot translocated substrates and their host targets. Future Microbiol 9: 343-359.
    • (2014) Future Microbiol , vol.9 , pp. 343-359
    • Isaac, D.T.1    Isberg, R.2
  • 20
    • 84872089363 scopus 로고    scopus 로고
    • Enrichment of outer membrane vesicles shed by Legionella pneumophila
    • Jäger, J., and Steinert, M. (2013) Enrichment of outer membrane vesicles shed by Legionella pneumophila. Methods Mol Biol 954: 225-230.
    • (2013) Methods Mol Biol , vol.954 , pp. 225-230
    • Jäger, J.1    Steinert, M.2
  • 21
    • 84890834419 scopus 로고    scopus 로고
    • Human lung tissue explants reveal novel interactions during Legionella pneumophila infections
    • Jäger, J., Marwitz, S., Tiefenau, J., Rasch, J., Shevchuk, O., Kugler, C., etal. (2014) Human lung tissue explants reveal novel interactions during Legionella pneumophila infections. Infect Immun 82: 275-285.
    • (2014) Infect Immun , vol.82 , pp. 275-285
    • Jäger, J.1    Marwitz, S.2    Tiefenau, J.3    Rasch, J.4    Shevchuk, O.5    Kugler, C.6
  • 22
    • 0022258991 scopus 로고
    • A comparison of virulence of two strains of Legionella pneumophila based on experimental aerosol infection of guinea-pigs
    • Jepras, R.I., Fitzgeorge, R.B., and Baskerville, A. (1985) A comparison of virulence of two strains of Legionella pneumophila based on experimental aerosol infection of guinea-pigs. J Hyg (Lond) 95: 29-38.
    • (1985) J Hyg (Lond) , vol.95 , pp. 29-38
    • Jepras, R.I.1    Fitzgeorge, R.B.2    Baskerville, A.3
  • 23
    • 84908210470 scopus 로고    scopus 로고
    • Pulmonary surfactant protein A-induced changes in the molecular conformation of bacterial deep-rough LPS lead to reduced activity on human macrophages
    • Keese, S.P., Brandenburg, K., Roessle, M., and Schromm, A.B. (2014) Pulmonary surfactant protein A-induced changes in the molecular conformation of bacterial deep-rough LPS lead to reduced activity on human macrophages. Innate Immun 20: 787-798.
    • (2014) Innate Immun , vol.20 , pp. 787-798
    • Keese, S.P.1    Brandenburg, K.2    Roessle, M.3    Schromm, A.B.4
  • 24
    • 84857663238 scopus 로고    scopus 로고
    • Roles of interleukin-17 in an experimental Legionella pneumophila pneumonia model
    • Kimizuka, Y., Kimura, S., Saga, T., Ishii, M., Hasegawa, N., Betsuyaku, T., etal. (2012) Roles of interleukin-17 in an experimental Legionella pneumophila pneumonia model. Infect Immun 80: 1121-1127.
    • (2012) Infect Immun , vol.80 , pp. 1121-1127
    • Kimizuka, Y.1    Kimura, S.2    Saga, T.3    Ishii, M.4    Hasegawa, N.5    Betsuyaku, T.6
  • 25
    • 0020114103 scopus 로고
    • X-ray diffraction and scattering on disordered systems using synchrotron radiation
    • Koch, M.H.J., and Bordas, J. (1983) X-ray diffraction and scattering on disordered systems using synchrotron radiation. Nucl Instrum Methods Phys Res 208: 461-469.
    • (1983) Nucl Instrum Methods Phys Res , vol.208 , pp. 461-469
    • Koch, M.H.J.1    Bordas, J.2
  • 26
    • 0019419424 scopus 로고
    • Control of arachidonic acid accumulation in bone marrow-derived macrophages by acyltransferases
    • Kröner, E.E., Peskar, B.A., Fischer, H., and Ferber, E. (1981) Control of arachidonic acid accumulation in bone marrow-derived macrophages by acyltransferases. J Biol Chem 256: 3690-3697.
    • (1981) J Biol Chem , vol.256 , pp. 3690-3697
    • Kröner, E.E.1    Peskar, B.A.2    Fischer, H.3    Ferber, E.4
  • 27
    • 84930367456 scopus 로고    scopus 로고
    • Biogenesis and multifaceted roles of outer membrane vesicles from Gram-negative bacteria
    • Kulkarni, H.M., and Jagannadham, M.V. (2014) Biogenesis and multifaceted roles of outer membrane vesicles from Gram-negative bacteria. Microbiology 160: 2109-2121.
    • (2014) Microbiology , vol.160 , pp. 2109-2121
    • Kulkarni, H.M.1    Jagannadham, M.V.2
  • 28
    • 77957959533 scopus 로고    scopus 로고
    • Biological functions and biogenesis of secreted bacterial outer membrane vesicles
    • Kulp, A., and Kuehn, M.J. (2010) Biological functions and biogenesis of secreted bacterial outer membrane vesicles. Annu Rev Microbiol 64: 163-184.
    • (2010) Annu Rev Microbiol , vol.64 , pp. 163-184
    • Kulp, A.1    Kuehn, M.J.2
  • 29
    • 47249132519 scopus 로고    scopus 로고
    • Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation
    • Mashburn-Warren, L., Howe, J., Garidel, P., Richter, W., Steiniger, F., Roessle, M., etal. (2008) Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation. Mol Microbiol 69: 491-502.
    • (2008) Mol Microbiol , vol.69 , pp. 491-502
    • Mashburn-Warren, L.1    Howe, J.2    Garidel, P.3    Richter, W.4    Steiniger, F.5    Roessle, M.6
  • 30
    • 3042687722 scopus 로고    scopus 로고
    • Disruption of the phagosomal membrane and egress of Legionella pneumophila into the cytoplasm during the last stages of intracellular infection of macrophages and Acanthamoeba polyphaga
    • Molmeret, M., Bitar, D.M., Han, L., and Kwaik, Y.A. (2004) Disruption of the phagosomal membrane and egress of Legionella pneumophila into the cytoplasm during the last stages of intracellular infection of macrophages and Acanthamoeba polyphaga. Infect Immun 72: 4040-4051.
    • (2004) Infect Immun , vol.72 , pp. 4040-4051
    • Molmeret, M.1    Bitar, D.M.2    Han, L.3    Kwaik, Y.A.4
  • 31
    • 84870050950 scopus 로고    scopus 로고
    • Outer membrane vesicles from Brucella abortus promote bacterial internalization by human monocytes and modulate their innate immune response
    • Pollak, C.N., Delpino, M.V., Fossati, C.A., and Baldi, P.C. (2012) Outer membrane vesicles from Brucella abortus promote bacterial internalization by human monocytes and modulate their innate immune response. PLoS ONE 7: e50214.
    • (2012) PLoS ONE , vol.7 , pp. e50214
    • Pollak, C.N.1    Delpino, M.V.2    Fossati, C.A.3    Baldi, P.C.4
  • 32
    • 79953304475 scopus 로고    scopus 로고
    • Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice
    • Prados-Rosales, R., Baena, A., Martinez, L.R., Luque-Garcia, J., Kalscheuer, R., Veeraraghavan, U., etal. (2011) Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice. J Clin Invest 121: 1471-1483.
    • (2011) J Clin Invest , vol.121 , pp. 1471-1483
    • Prados-Rosales, R.1    Baena, A.2    Martinez, L.R.3    Luque-Garcia, J.4    Kalscheuer, R.5    Veeraraghavan, U.6
  • 33
    • 84874118216 scopus 로고    scopus 로고
    • Intact rough- and smooth-form lipopolysaccharides from Escherichia coli separated by preparative gel electrophoresis exhibit differential biologic activity in human macrophages
    • Pupo, E., Lindner, B., Brade, H., and Schromm, A.B. (2013) Intact rough- and smooth-form lipopolysaccharides from Escherichia coli separated by preparative gel electrophoresis exhibit differential biologic activity in human macrophages. FEBS J 280: 1095-1111.
    • (2013) FEBS J , vol.280 , pp. 1095-1111
    • Pupo, E.1    Lindner, B.2    Brade, H.3    Schromm, A.B.4
  • 34
    • 0038298731 scopus 로고    scopus 로고
    • Mechanism of the lamellar/inverse hexagonal phase transition examined by high resolution x-ray diffraction
    • Rappolt, M., Hickel, A., Bringezu, F., and Lohner, K. (2003) Mechanism of the lamellar/inverse hexagonal phase transition examined by high resolution x-ray diffraction. Biophys J 84: 3111-3122.
    • (2003) Biophys J , vol.84 , pp. 3111-3122
    • Rappolt, M.1    Hickel, A.2    Bringezu, F.3    Lohner, K.4
  • 35
    • 34248347847 scopus 로고    scopus 로고
    • Upgrade of the small-angle X-ray scattering beamline X33 at the European Molecular Biology Laboratory, Hamburg
    • Roessle, M.W., Klaering, R., Ristau, U., Robrahn, B., Jahn, D., Gehrmann, T., etal. (2007) Upgrade of the small-angle X-ray scattering beamline X33 at the European Molecular Biology Laboratory, Hamburg. J Appl Crystallogr 40: 190-194.
    • (2007) J Appl Crystallogr , vol.40 , pp. 190-194
    • Roessle, M.W.1    Klaering, R.2    Ristau, U.3    Robrahn, B.4    Jahn, D.5    Gehrmann, T.6
  • 36
    • 0030590914 scopus 로고    scopus 로고
    • Lipopolysaccharide-binding protein mediates CD14-independent intercalation of lipopolysaccharide into phospholipid membranes
    • Schromm, A.B., Brandenburg, K., Rietschel, E.T., Flad, H.D., Carroll, S.F., and Seydel, U. (1996) Lipopolysaccharide-binding protein mediates CD14-independent intercalation of lipopolysaccharide into phospholipid membranes. FEBS Lett 399: 267-271.
    • (1996) FEBS Lett , vol.399 , pp. 267-271
    • Schromm, A.B.1    Brandenburg, K.2    Rietschel, E.T.3    Flad, H.D.4    Carroll, S.F.5    Seydel, U.6
  • 37
    • 34249678347 scopus 로고    scopus 로고
    • Physicochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation
    • Schromm, A.B., Howe, J., Ulmer, A.J., Wiesmuller, K.H., Seyberth, T., Jung, G., etal. (2007) Physicochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation. J Biol Chem 282: 11030-11037.
    • (2007) J Biol Chem , vol.282 , pp. 11030-11037
    • Schromm, A.B.1    Howe, J.2    Ulmer, A.J.3    Wiesmuller, K.H.4    Seyberth, T.5    Jung, G.6
  • 38
    • 77955260830 scopus 로고    scopus 로고
    • Influence of serum on the immune recognition of a synthetic lipopeptide mimetic of the 19-kDa lipoprotein from Mycobacterium tuberculosis
    • Schromm, A.B., Reiling, N., Howe, J., Wiesmuller, K.H., Roessle, M., and Brandenburg, K. (2010) Influence of serum on the immune recognition of a synthetic lipopeptide mimetic of the 19-kDa lipoprotein from Mycobacterium tuberculosis. Innate Immun 16: 213-225.
    • (2010) Innate Immun , vol.16 , pp. 213-225
    • Schromm, A.B.1    Reiling, N.2    Howe, J.3    Wiesmuller, K.H.4    Roessle, M.5    Brandenburg, K.6
  • 39
    • 84877316643 scopus 로고    scopus 로고
    • Envelope control of outer membrane vesicle production in Gram-negative bacteria
    • Schwechheimer, C., Sullivan, C.J., and Kuehn, M.J. (2013) Envelope control of outer membrane vesicle production in Gram-negative bacteria. Biochemistry 52: 3031-3040.
    • (2013) Biochemistry , vol.52 , pp. 3031-3040
    • Schwechheimer, C.1    Sullivan, C.J.2    Kuehn, M.J.3
  • 40
    • 0027281951 scopus 로고
    • Structural polymorphisms of rough mutant lipopolysaccharides Rd to Ra from Salmonella minnesota
    • Seydel, U., Koch, M.H., and Brandenburg, K. (1993) Structural polymorphisms of rough mutant lipopolysaccharides Rd to Ra from Salmonella minnesota. J Struct Biol 110: 232-243.
    • (1993) J Struct Biol , vol.110 , pp. 232-243
    • Seydel, U.1    Koch, M.H.2    Brandenburg, K.3
  • 41
    • 70350728797 scopus 로고    scopus 로고
    • Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophages
    • Shim, H.K., Kim, J.Y., Kim, M.J., Sim, H.S., Park, D.W., and Sohn, J.W. (2009) Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophages. Exp Mol Med 41: 687-694.
    • (2009) Exp Mol Med , vol.41 , pp. 687-694
    • Shim, H.K.1    Kim, J.Y.2    Kim, M.J.3    Sim, H.S.4    Park, D.W.5    Sohn, J.W.6
  • 42
    • 57149112520 scopus 로고    scopus 로고
    • Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila
    • Shin, S., Case, C.L., Archer, K.A., Nogueira, C.V., Kobayashi, K.S., Flavell, R.A., etal. (2008) Type IV secretion-dependent activation of host MAP kinases induces an increased proinflammatory cytokine response to Legionella pneumophila. PLoS Pathog 4: e1000220.
    • (2008) PLoS Pathog , vol.4 , pp. e1000220
    • Shin, S.1    Case, C.L.2    Archer, K.A.3    Nogueira, C.V.4    Kobayashi, K.S.5    Flavell, R.A.6


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