Serum 25-hydroxyvitamin D is associated with major cardiovascular risk factors and cardiac structure and function in patients with coronary artery disease

Nutrition, Metabolism and Cardiovascular Diseases

Volumn 25, Issue 5, 2015, Pages 471-478

  Pekkanen, M P ^a   Ukkola, O ^a   Hedberg, P ^a   Piira, O P ^a   Lepojarvi S ^a   Lumme, J ^a   Tulppo, M P ^b,c   Huikuri, H V ^a  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b Verve   (Finland)

^c LONDON SOUTH BANK UNIVERSITY   (United Kingdom)

Author keywords

Cardiac ultrasound; Diastolic dysfunction; Risk factors; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; C REACTIVE PROTEIN; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; 25 HYDROXYERGOCALCIFEROL; CALCIFEDIOL;

ADULT; AGED; ARTERY DIAMETER; ARTICLE; BLOOD ANALYSIS; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIASTOLIC DYSFUNCTION; DOPPLER ECHOCARDIOGRAPHY; FEMALE; GLUCOSE TOLERANCE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FILLING; HEART VENTRICLE SIZE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INTRACARDIAC ECHOCARDIOGRAPHY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MITRAL VALVE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK FACTOR; URINALYSIS; VERY ELDERLY; BLOOD; CARDIOVASCULAR DISEASES; COHORT ANALYSIS; ECHOGRAPHY; FINLAND; HEART; HEART ATRIUM; HEART LEFT VENTRICLE FUNCTION; HEART STROKE VOLUME; HEART VENTRICLE; NUTRITIONAL STATUS; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PREVALENCE; VITAMIN D DEFICIENCY;

25-HYDROXYVITAMIN D 2; ADULT; AGED; AGED, 80 AND OVER; CALCIFEDIOL; CARDIOVASCULAR DISEASES; COHORT STUDIES; CORONARY ARTERY DISEASE; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; FINLAND; HEART; HEART ATRIA; HEART VENTRICLES; HUMANS; MALE; MIDDLE AGED; NUTRITIONAL STATUS; ORGAN SIZE; PREVALENCE; RISK FACTORS; STROKE VOLUME; VENTRICULAR DYSFUNCTION, LEFT; VITAMIN D DEFICIENCY;

EID: 84927799403     PISSN: 09394753     EISSN: 15903729     Source Type: Journal    
DOI: 10.1016/j.numecd.2015.02.005     Document Type: Article

References (31)

1. Wong Y.Y., McCaul K.A., Yeap B.B., Hankey G.J., Flicker L. Low vitamin D status is an independent predictor of increased frailty and all-cause mortality in older men: the Health in Men Study. J Clin Endocrinol Metab 2013, 98:3821-3828.
2. Wang C. Role of vitamin d in cardiometabolic diseases. J Diabetes. Res 2013, 243934. [Epub 2013 Feb 25]. 10.1155/2013/243934.
3. Siadat Z.D., Kiani K., Sadeghi M., Shariat A.S., Farajzadegan Z., Kheirmand M. Association of vitamin D deficiency and coronary artery disease with cardiovascular risk factors. J Res Med Sci 2012, 17:1052-1055.
4. Meems L.M., Cannon M.V., Mahmud H., Voors A.A., van Gilst W.H., Sillje H.H., et al. The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload. J Steroid Biochem Mol Biol 2012, 132:282-289.
5. Mann M.C., Exner D.V., Hemmelgarn B.R., Sola D.Y., Turin T.C., Ellis L., et al. Vitamin d levels are associated with cardiac autonomic activity in healthy humans. Nutrients 2013, 5:2114-2127.
6. McGreevy C., Williams D. New insights about vitamin D and cardiovascular disease: a narrative review. Ann Intern Med 2011, 155:820-826.
7. Fall T., Shiue I., Bergea af Geijerstam P., Sundström J., Arnlov J., Larsson A., et al. Relations of circulating vitamin D concentrations with left ventricular geometry and function. Eur J Heart Fail 2012, 14:985-991.
8. Tamez H., Zoccali C., Packham D., Wenger J., Bhan I., Appelbaum E., et al. Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease. Am Heart J 2012, 164:902-909.e2.
9. Song Y., Wang L., Pittas A.G., Del Gobbo L.C., Zhang C., Manson J.E., et al. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care 2013, 36:1422-1428.
10. Bonakdaran S., Rokni H. Diabetic CVD-focus on vitamin D. Cardiovasc Hematol Agents Med Chem 2012, 10:241-250.
11. Cioffi G., Faggiano P., Lucci D., Maggioni A.P., Manicardi V., Travaglini A., et al. Left ventricular dysfunction and outcome at two-year follow-up in patients with type 2 diabetes: the DYDA study. Diabetes Res Clin Pract 2013, 101:236-242.
12. Ichikawa R., Daimon M., Miyazaki T., Kawata T., Miyazaki S., Maruyama M., et al. Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus. Cardiovasc Diabetol 2013, 12:38. 10.1186/1475-2840-12-38.
13. Lorell B.H., Carabello B.A. Left ventricular hypertrophy: pathogenesis, detection, and prognosis. Circulation 2000, 102:470-479.
14. Alberti K.G., Zimmet P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998, 15:539-553.
15. Wortsman J., Matsuoka L.Y., Chen T.C., Lu Z., Holick M.F. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000, 72:690-693.
16. Martins D., Wolf M., Pan D., Zadshir A., Tareen N., Thadhani R., et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med 2007, 167:1159-1165.
17. Stivelman E., Retnakaran R. Role of vitamin D in the pathophysiology and treatment of type 2 diabetes. Curr Diabetes Rev 2012, 8:42-47.
18. Jorde R., Grimnes G. Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. Prog Lipid Res 2011, 50:303-312.
19. Geleijnse J.M. Vitamin D and the prevention of hypertension and cardiovascular diseases: a review of the current evidence. Am J Hypertens 2011, 24:253-262.
20. Forman J.P., Williams J.S., Fisher N.D. Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans. Hypertension 2010, 55:1283-1288.
21. Meems L.M., van der Harst P., van Gilst W.H., de Boer R.A. Vitamin D biology in heart failure: molecular mechanisms and systematic review. Curr Drug Targets 2011, 12:29-41.
22. Assalin H.B., Rafacho B.P., dos Santos P.P., Ardisson L.P., Roscani M.G., Chiuso-Minicucci F., et al. Impact of the length of vitamin D deficiency on cardiac remodelling. Circ Heart Fail 2014, 6:809-816.
23. Fallo F., Catena C., Camozzi V., Luisetto G., Cosma C., Plebani M., et al. Low serum 25-hydroxyvitamin D levels are associated with left ventricular hypertrophy in essential hypertension. Nutr Metab Cardiovasc Dis 2012, 22:871-876.
24. Ameri P., Ronco D., Casu M., Denegri A., Bovio M., Menoni S., et al. High prevalence of vitamin D deficiency and its association with left ventricular dilation: an echocardiography study in elderly patients with chronic heart failure. Nutr Metab Cardiovasc Dis 2010, 20:633-640.
25. Kamycheva E., Wilsgaard T., Schirmer H., Jorde R. Serum 25-hydroxyvitamin D and left ventricular systolic function in a non-smoking population: the Tromso Study. Eur J Heart Fail 2013, 15:490-495.
26. Weishaar R.E., Simpson R.U. Involvement of vitamin D3 with cardiovascular function. II. Direct and indirect effects. Am J Physiol 1987, 253:E675-E683.
27. Pilz S., Marz W., Wellnitz B., Seelhorst U., Fahrleitner-Pammer A., Dimai H.P., et al. Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. J Clin Endocrinol Metab 2008, 93:3927-3935.
28. Pilz S., Henry R.M., Snijder M.B., van Dam R.M., Nijpels G., Stehouwer C.D., et al. Vitamin D deficiency and myocardial structure and function in older men and women: the Hoorn study. J Endocrinol Invest 2010, 33:612-617.
29. Akn F., Ayca B., Kose N., Celik O., Ylmaz Y., Akn M.N., et al. Serum vitamin D and c-reactive protein levels are independently associated with diastolic dysfunction. J Investig Med 2014, 62:43-48.
30. Pandit A., Mookadam F., Boddu S., Aryal Pandit A., Tandar A., Chaliki H., et al. Vitamin D levels and left ventricular diastolic function. Open Heart 2014, 1(1):e000011. eCollection 2014. 10.1136/openhrt-2013-000011.
31. Miettinen M.E., Kinnunen L., Leiviskä J., Keinänen-Kiukaanniemi S., Korpi-Hyövälti E., Niskanen L., et al. Association of serum 25-hydroxyvitamin D with lifestyle factors and metabolic and cardiovascular disease markers: population-based cross-sectional study (FIN-D2D). PLoS One 2014, 9(7):e100235.