Antimicrobial delay and outcome in severe sepsis: To the editor

Critical Care Medicine

Volumn 42, Issue 12, 2014, Pages e802-

  Kumar, Anand ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; HYPERTENSIVE FACTOR; LACTIC ACID;

ANTIMICROBIAL THERAPY; HUMAN; LETTER; MORTALITY; OUTCOME ASSESSMENT; PRACTICE GUIDELINE; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; SURVIVAL; FEMALE; INTENSIVE CARE UNIT; MALE; SHOCK, SEPTIC; STANDARDS; STATISTICS AND NUMERICAL DATA; TOTAL QUALITY MANAGEMENT;

ANTI-BACTERIAL AGENTS; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; QUALITY IMPROVEMENT; SEPSIS; SHOCK, SEPTIC;

EID: 84927778743     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000620     Document Type: Letter

References (7)

1. Ferrer R, Martin-Loeches I, Phillips G, et al: Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour: Results From a Guideline-Based Performance Improvement Program. Crit Care Med 2014;42:1749-1755
2. Kumar A, Roberts D, Wood KE, et al: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34:1589-1596
3. Kumar A, Haery C, Paladugu B, et al: The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: Association with serum lactate and inflammatory cytokine levels. J Infect Dis 2006;193:251-258
4. Kumar A, Zarychanski R, Light B, et al; Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group: Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis. Crit Care Med 2010;38:1773-1785
5. Kumar A: An alternate pathophysiologic paradigm of sepsis and septic shock: Implications for optimizing antimicrobial therapy. Virulence 2014;5:80-97
6. Meehan TP, Fine MJ, Krumholz HM, et al: Quality of care, process, and outcomes in elderly patients with pneumonia. JAMA 1997;278:2080-2084
7. Dellinger RP, Levy MM, Rhodes A, et al; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup: Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41:580-637