Role of renal oxygenation and mitochondrial function in the pathophysiology of acute kidney injury

Nephron - Clinical Practice

Volumn 127, Issue 1-4, 2014, Pages 149-152

  Nourbakhsh, Noureddin ^a   Singh, Prabhleen ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Metabolism; Mitochondrial function; Oxygenation; Transport

Indexed keywords

ACUTE DISEASE; ACUTE KIDNEY FAILURE; CELL FUNCTION; CHRONIC DISEASE; CONFERENCE PAPER; HUMAN; HYPOXIA; ISCHEMIA; MITOCHONDRION; NONHUMAN; OXYGENATION; PATHOPHYSIOLOGY; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; RENAL OXYGENATION; REPERFUSION INJURY; SEPSIS; ACUTE KIDNEY INJURY; ANIMAL; CELL HYPOXIA; COMPLICATION; DISEASE MODEL; ENERGY METABOLISM; GLOMERULUS FILTRATION RATE; KIDNEY; KIDNEY CIRCULATION; KIDNEY PROXIMAL TUBULE; METABOLISM; MITOCHONDRIAL DYNAMICS; OXIDATION REDUCTION REACTION; OXYGEN CONSUMPTION; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL; VASCULARIZATION; VASOCONSTRICTION;

OXYGEN; SODIUM;

ACUTE KIDNEY INJURY; ANIMALS; BIOLOGICAL TRANSPORT; CELL HYPOXIA; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; KIDNEY TUBULES, PROXIMAL; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; OXIDATION-REDUCTION; OXYGEN; OXYGEN CONSUMPTION; RENAL CIRCULATION; REPERFUSION INJURY; SEPSIS; SODIUM; VASOCONSTRICTION;

EID: 84927769939     PISSN: None     EISSN: 16602110     Source Type: Journal    
DOI: 10.1159/000363545     Document Type: Conference Paper

References (25)

1. Evans RG, et al: Intrarenal oxygenation: unique challenges and the biophysical basis of homeostasis. Am J Physiol Renal Physiol 2008; 295:F1259-F1270.
2. Cohen JJ: Renal metabolism: relation to renal function; in Brenner BM (ed): The Kidney. Philadelphia, Saunders, 1981.
3. Deetjen P, Kramer K: The relation of O 2 consumption by the kidney to Na re-resorption (in German). Pflügers Arch Gesamte Physiol Menschen Tiere 1961; 273: 636-650.
4. Mandel LJ: Primary active sodium transport, oxygen consumption, and ATP: coupling and regulation. Kidney Int 1986; 29: 3-9.
5. Epstein FH, Agmon Y, Brezis M: Physiology of renal hypoxia. Ann NY Acad Sci 1994; 718: 72-81, discussion 81-82.
6. Addabbo F, Montagnani M, Goligorsky MS: Mitochondria and reactive oxygen species. Hypertension 2009; 53: 885-892.
7. Westermann B: Bioenergetic role of mitochondrial fusion and fission. Biochim Biophys Acta 2012; 1817: 1833-1838.
8. Legrand M, Almac E, Mik EG, et al: L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats. Am J Physiol Renal Physiol 2009; 296:F1109-F1117.
9. Oostendorp M, de Vries EE, Slenter JM, Peutz-Kootstra CJ, Snoeijs MG, Post MJ, van Heurn LW, Backes WH: MRI of renal oxygenation and function after normothermic ischemia-reperfusion injury. NMR Biomed 2011; 24: 194-200.
10. Pohlmann A, Hentschel J, Fechner M, Hoff U, Bubalo G, Arakelyan K, Cantow K, Seeliger E, Flemming B, Waiczies H, Waiczies S, Schunck WH, Dragun D, Niendorf T: High temporal resolution parametric MRI monitoring of the initial ischemia/reperfusion phase in experimental acute kidney injury. PLoS One 2013; 8:e57411.
11. Ricksten SE, Bragadottir G, Redfors B: Renal oxygenation in clinical acute kidney injury. Crit Care 2013; 17: 221.
12. Redfors B, et al: Acute renal failure is NOT an 'acute renal success'-a clinical study on the renal oxygen supply/demand relationship in acute kidney injury. Crit Care Med 2010; 38: 1695-1701.
13. Park JS, Pasupulati R, Feldkamp T, Roeser NF, Weinberg JM: Cyclophilin D and the mitochondrial permeability transition in kidney proximal tubules after hypoxic and ischemic injury. Am J Physiol Renal Physiol 2011; 301:F134-F150.
14. Zhan M, Brooks C, Liu F, Sun L, Dong Z: Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology. Kidney Int 2013; 83: 568-581.
15. Brooks C, Wei Q, Cho SG, Dong Z: Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest 2009; 119: 1275-1285.
16. Castaneda MP, Swiatecka-Urban A, Mitsnefes MM, Feuerstein D, Kaskel FJ, Tellis V, Devarajan P: Activation of mitochondrial apoptotic pathways in human renal allografts after ischemia-reperfusion injury. Transplantation 2003; 76: 50-54.
17. Funk JA, Schnellmann RG: Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia-reperfusion injury. Toxicol Appl Pharmacol 2013; 273: 345-354.
18. Hall AM, Rhodes GJ, Sandoval RM, Corridon PR, Molitoris BA: In vivo multiphoton imaging of mitochondrial structure and function during acute kidney injury. Kidney Int 2013; 83: 72-83.
19. Schrier RW, Wang W: Acute renal failure and sepsis. N Engl J Med 2004; 351: 159-169.
20. Langenberg C, Bellomo R, May C, Wan L, Egi M, Morgera S: Renal blood flow in sepsis. Crit Care 2005; 9:R363-R374.
21. Brenner M, Schaer GL, Mallory DL, Suffredini AF, Parrillo JE: Detection of renal blood flow abnormalities in septic and critically ill patients using a newly designed indwelling thermodilution renal vein catheter. Chest 1990; 98: 170-179.
22. Heemskerk AEJ, et al: Renal function and oxygen consumption during bacteremia and endotoxaemia in rats. Nephrol Dial Transplant 1997; 12: 1586-1594.
23. Vaz AJ: Low fractional excretion of urine sodium in acute renal failure due to sepsis. Arch Intern Med 1983; 143: 738-739.
24. Langenberg C, Bagshaw SM, May CN, Bellomo R: The histopathology of septic acute kidney injury: a systematic review. Crit Care 2008; 12:R38.
25. Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM: PGC-1alpha promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest 2011; 121: 4003-4014.