Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: A phase II study by the Japan Adult Leukemia Study Group

Blood Cancer Journal

Volumn 4, Issue 10, 2014, Pages

  Hayakawa, F ^a   Sakura, T ^b   Yujiri, T ^c   Kondo, E ^d   Fujimaki, K ^e   Sasaki, O ^f   Miyatake, J ^g   Handa, H ^h   Ueda, Y ⁱ   Aoyama, Y ^j   Takada, S ^b   Tanaka, Y ^c   Usui, N ^k   Miyawaki, S ^l   Suenobu, S ^m   Horibe, K ⁿ   Kiyoi, H ^a   Ohnishi, K ^o   Miyazaki, Y ^p   Ohtake, S ^q   Kobayashi, Y ^r   Matsuo, K ^s   Naoe, T ⁿ   more..

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SAISEIKAI MAEBASHI HOSPITAL   (Japan)

^c YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

^e Fujisawa City Hospital   (Japan)

^f Miyagi Cancer Center   (Japan)

^g KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^h GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

ⁱ KURASHIKI CENTRAL HOSPITAL   (Japan)

^j Fuchu Hospital   (Japan)

^k JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^l Tokyo Metropolitan Ohtsuka Hospital   (Japan)

^m OITA UNIVERSITY   (Japan)

ⁿ NATIONAL HOSPITAL ORGANIZATION NAGOYA MEDICAL CENTER   (Japan)

^o HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^p NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^q KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^r NATIONAL CANCER CENTER HOSPITAL   (Japan)

^s KYUSHU UNIVERSITY   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINASE; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; HYDROCORTISONE; MERCAPTOPURINE; METHOTREXATE; PIRARUBICIN; PREDNISOLONE; VINCRISTINE; ANTINEOPLASTIC AGENT;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; BRAIN HEMORRHAGE; CANCER PATIENT; CANCER PROGNOSIS; CLINICAL PROTOCOL; DIARRHEA; DISEASE FREE SURVIVAL; DISEASE SEVERITY; DISSEMINATED INTRAVASCULAR CLOTTING; FEASIBILITY STUDY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEART DISEASE; HUMAN; HYPERGLYCEMIA; ILEUS; INFECTION; LEUKEMIA REMISSION; LIVER TOXICITY; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NEUROPATHY; NEUTROPENIA; ONCOGENE; OVERALL SURVIVAL; PANCREATITIS; PATIENT COMPLIANCE; PHASE 2 CLINICAL TRIAL (TOPIC); SEPSIS; SIDE EFFECT; THROMBOCYTOPENIA; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR LYSIS SYNDROME; AGE; ANTAGONISTS AND INHIBITORS; CLINICAL TRIAL; JAPAN; MORTALITY; MULTICENTER STUDY; PHASE 2 CLINICAL TRIAL; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROSPECTIVE STUDY; REMISSION; SURVIVAL RATE; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; JAPAN; MALE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROSPECTIVE STUDIES; REMISSION INDUCTION; SURVIVAL RATE; YOUNG ADULT;

EID: 84927760584     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2014.72     Document Type: Article

References (18)

1. Pulte D, Gondos A, Brenner H. Trends in 5-and 10-year survival after diagnosis with childhood hematologic malignancies in the United States, 1990-2004. J Natl Cancer Inst 2008; 100: 1301-1309
2. Pulte D, Gondos A, Brenner H. Improvement in survival in younger patients with acute lymphoblastic leukemia from the 1980 s to the early 21st century. Blood 2009; 113: 1408-1411
3. Boissel N, Auclerc MF, Lheritier V, Perel Y, Thomas X, Leblanc T et al. Should adolescents with acute lymphoblastic leukemia be treated as old children or young adults? Comparison of the French FRALLE-93 and LALA-94 trials. J Clin Oncol 2003; 21: 774-780
4. Ramanujachar R, Richards S, Hann I, Goldstone A, Mitchell C, Vora A et al. Adolescents with acute lymphoblastic leukaemia: outcome on UK national paediatric (ALL97) and adult (UKALLXII/E2993) trials. Pediatr Blood Cancer 2007; 48: 254-261
5. Stock W, La M, Sanford B, Bloomfield CD, Vardiman JW, Gaynon P et al. What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of Children's Cancer Group and Cancer and Leukemia Group B studies. Blood 2008; 112: 1646-1654
6. de Bont JM, Holt B, Dekker AW, van der Does-van den Berg A, Sonneveld P, Pieters R. Significant difference in outcome for adolescents with acute lymphoblastic leukemia treated on pediatric vs adult protocols in the Netherlands. Leukemia 2004; 18: 2032-2035
7. Barry E, DeAngelo DJ, Neuberg D, Stevenson K, Loh ML, Asselin BL et al. Favorable outcome for adolescents with acute lymphoblastic leukemia treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Protocols. J Clin Oncol 2007; 25: 813-819
8. Nachman JB, La MK, Hunger SP, Heerema NA, Gaynon PS, Hastings C et al. Young adults with acute lymphoblastic leukemia have an excellent outcome with chemotherapy alone and benefit from intensive postinduction treatment: A report from the children's oncology group. J Clin Oncol 2009; 27: 5189-5194
9. Huguet F, Leguay T, Raffoux E, Thomas X, Beldjord K, Delabesse E et al. Pediatric-inspired therapy in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia: The GRAALL-2003 study. J Clin Oncol 2009; 27: 911-918
10. Storring JM, Minden MD, Kao S, Gupta V, Schuh AC, Schimmer AD et al. Treatment of adults with BCR-ABL negative acute lymphoblastic leukaemia with a modified paediatric regimen. Br J Haematol 2009; 146: 76-85
11. Ribera JM, Oriol A, Sanz MA, Tormo M, Fernandez-Abellan P, del Potro E et al. Comparison of the results of the treatment of adolescents and young adults with standardrisk acute lymphoblastic leukemia with the Programa Espanol de Tratamiento en Hematologia pediatric-based protocol ALL-96. J Clin Oncol 2008; 26: 1843-1849
12. Towatari M, Yanada M, Usui N, Takeuchi J, Sugiura I, Takeuchi M et al. Combination of intensive chemotherapy and imatinib can rapidly induce highquality complete remission for a majority of patients with newly diagnosed BCRABL-positive acute lymphoblastic leukemia. Blood 2004; 104: 3507-3512
13. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR et al. Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol 1976; 33: 451-458
14. Jinnai I, Sakura T, Tsuzuki M, Maeda Y, Usui N, Kato M et al. Intensified consolidation therapy with dose-escalated doxorubicin did not improve the prognosis of adults with acute lymphoblastic leukemia: The JALSG-ALL97 study. Int J Hematol 2010; 92: 490-502
15. Hasegawa D, Hara J, Suenobu S, Takahashi Y, Sato A, Suzuki N et al. Successful Abolition of prophylactic cranial irradiation in children with non-T acute lymphoblastic leukemia (ALL) in the Japan Association of Childhood Leukemia Study (JACLS) ALL-02 Trial. ASH Annual Meeting Abstracts 2011; 118: 1506
16. Pullarkat V, Slovak ML, Kopecky KJ, Forman SJ, Appelbaum FR. Impact of cytogenetics on the outcome of adult acute lymphoblastic leukemia: results of Southwest Oncology Group 9400 study. Blood 2008; 111: 2563-2572
17. Schrappe M, Reiter A, Ludwig WD, Harbott J, Zimmermann M, Hiddemann W et al. Improved outcome in childhood acute lymphoblastic leukemia despite reduced use of anthracyclines and cranial radiotherapy: results of trial ALL-BFM 90. German-Austrian-Swiss ALL-BFM Study Group. Blood 2000; 95: 3310-3322
18. Nachman J, Sather HN, Gaynon PS, Lukens JN, Wolff L, Trigg ME. Augmented Berlin-Frankfurt-Munster therapy abrogates the adverse prognostic significance of slow early response to induction chemotherapy for children and adolescents with acute lymphoblastic leukemia and unfavorable presenting features: A report from the Children's Cancer Group. J Clin Oncol 1997; 15: 2222-2230.