Effect of delayed graft function, acute rejection and chronic allograft dysfunction on kidney allograft telomere length in patients after transplantation: A prospective cohort study

BMC Nephrology

Volumn 16, Issue 1, 2015, Pages

  Domański, Leszek ^a   Kłoda, Karolina ^a   Kwiatkowska, Ewa ^a   Borowiecka, Ewa ^a   Safranow, Krzysztof ^a   Drozd, Arleta ^a   Ciechanowicz, Andrzej ^b   Ciechanowski, Kazimierz ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

^b Department of Biochemistry and Human Nutrition Pomeranian Medical University in Szczecin ^*  (Poland)

Author keywords

Ageing; AR; CAD; Cellular senescence; DGF; Telomere length

Indexed keywords

ACUTE GRAFT REJECTION; ADULT; AGE; ARTICLE; CADAVER DONOR; CAUCASIAN; CHRONIC ALLOGRAFT NEPHROPATHY; COHORT ANALYSIS; CORRELATION ANALYSIS; DELAYED GRAFT FUNCTION; FEMALE; GRAFT RECIPIENT; HUMAN; HUMAN TISSUE; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; PROSPECTIVE STUDY; TELOMERE; ACUTE DISEASE; ALLOGRAFT; CADAVER; CELL AGING; CHRONIC DISEASE; GENETICS; GRAFT REJECTION; HEMODIALYSIS; KIDNEY; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; METABOLISM; PATHOLOGY; PRIMARY GRAFT DYSFUNCTION; TELOMERE SHORTENING; TIME FACTOR;

ACUTE DISEASE; ADULT; ALLOGRAFTS; CADAVER; CELL AGING; CHRONIC DISEASE; COHORT STUDIES; DELAYED GRAFT FUNCTION; FEMALE; GRAFT REJECTION; HUMANS; KIDNEY; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PRIMARY GRAFT DYSFUNCTION; PROSPECTIVE STUDIES; RENAL DIALYSIS; TELOMERE; TELOMERE SHORTENING; TIME FACTORS;

EID: 84927757326     PISSN: None     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/s12882-015-0014-8     Document Type: Article

References (26)

1. Norin AJ, Mondragon-Escorpizo MO, Brar A, Hochman D, Sumrani N, Distant DA, et al. Poor kidney allograft survival associated with positive B cell - Only flow cytometry cross matches: a ten year single center study. Hum Immunol. 2013;74:1304-12.
2. Moszkowska G, Zielińska H, Zieliński M, Dukat-Mazurek A, Dębska-͆lizień A, Rutkowski B, et al. Identification of patients with increased immunological risk among potential kidney recipients in the Polish population. Hum Immunol. 2014;75:650-5.
3. Kosieradzki M, Lisik W, Rowiński W, Malkowski P. Progress in abdominal organ transplantation. Med Sci Monit. 2011;17:RA282-91.
4. Krajewska M, Kościelska-Kasprzak K, Weyde W, Drulis-Fajdasz D, Madziarska K, Mazanowska O, et al. Impact of donor-dependent genetic factors on long-term renal graft function. Transplant Proc. 2009;41:2978-80.
5. Kim IW, Moon YJ, Ji E, Kim KI, Han N, Kim SJ, et al. Clinical and genetic factors affecting tacrolimus trough levels and drug-related outcomes in Korean kidney transplant recipients. Eur J Clin Pharmacol. 2012;68:657-69.
6. Kłoda K, Domański L, Pawlik A, Safranow K, Ciechanowski K. The impact of ICAM1 and VCAM1 gene polymorphisms on long-term renal transplant function and recipient outcomes. Ann Transplant. 2013;20:231-7.
7. Kim TH, Jeong KH, Kim SK, Lee SH, Ihm CG, Lee TW, et al. TLR9 gene polymorphism (rs187084, rs352140): association with acute rejection and estimated glomerular filtration rate in renal transplant recipients. Int J Immunogenet. 2013;40:502-8.
8. Gaafar A, Iqniebi A, Sheereen A, Eldali A, Turpeinen H, Adra C, et al. Study of the cytokine polymorphisms in correlation to rejection and graft survival in renal allograft donors and recipients from a homogenous Saudi population. Transpl Immunol. 2014;30:34-9.
9. Chen Z, Bouamar R, Van Schaik RH, De Fijter JW, Hartmann A, Zeier M, et al. Genetic polymorphisms in IL-2, IL-10, TGF-β1, and IL-2RB and acute rejection in renal transplant patients. Clin Transplant. 2014;28:649-55.
10. Oetting WS, Guan W, Schladt DP, Wildebush WA, Becker J, Thyagarajan B, et al. Telomere length of recipients and living kidney donors and chronic graft dysfunction in kidney transplants. Transplantation. 2014;97:325-9.
11. Matsubara Y, Murata M, Yoshida T, Watanabe K, Saito I, Miyaki K, et al. Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT. Biochem Biophys Res Commun. 2006;341:128-31.
12. Rodier F, Kim SH, Nijjar T, Yaswen P, Campisi J. Cancer and aging: the importance of telomeres in genome maintenance. Int J Biochem Cell Biol. 2005;37:977-90.
13. Ornish D, Lin J, Chan JM, Epel E, Kemp C, Weidner G, et al. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet. 2013;14:1112-20.
14. Morgan RG, Ives SJ, Walker AE, Cawthon RM, Andtbacka RH, Noyes D, et al. Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping. J Hypertens. 2014;32:1293-9.
15. Maubaret CG, Salpea KD, Romanoski CE, Folkersen L, Cooper JA, Stephanou C, et al. Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease. PLoS One. 2013;8:e83122.
16. Melk A, Ramassar V, Helis LMH, Moore R, Rayner D, Solez K, et al. Telomere shortening in kidneys with age. J Am Nephrol. 2000;11:444-53.
17. Ferlicot S, Durrbach A, Bâ N, Desvaux D, Bedossa P, Paradis V. The role of replicative senescence in chronic allograft nephropathy. Hum Pathol. 2003;34:924-8.
18. Joosten SA, van Ham V, Nolan CE, Borrias MC, Jardine AG, Shiels PG, et al. Telomere shortening and cellular senescence in a model of chronic renal allograft rejection. Am J Pathol. 2003;162:1305-12.
19. Cawthon RM. Telomere length measurement by a novel mono-chrome multiplex quantitative PCR method. Nucleic Acids Res. 2009;37:21.
20. O'Callaghan NJ, Fenech M. A quantitative PCR method for measuring absolute telomere length. Biol Proced Online. 2011;13:3.
21. Melk A, Schmidt BM, Braun H, Vongwiwatana A, Urmson J, Zhu LF, et al. Effects of donor age and cell senescence on kidney allograft survival. Am J Transplant. 2009;9:114-23.
22. Sanders JL, Newman AB. Telomere length in epidemiology: a bio-marker of aging, age-related disease, both, or neither? Epidemiol Rev. 2013;35:112-31.
23. Heidinger BJ, Blount JD, Boner W, Griffiths K, Metcalfe NB, Monaghan P. Telomere length in early life predicts lifespan. Proc Natl Acad Sci U S A. 2012;109:1743-8.
24. Koppelstaetter C, Schratzberger G, Perco P, Hofer J, Mark W, Ollinger R, et al. Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation. Aging Cell. 2008;7:491-7.
25. Joosten SA, van Kooten C, Sijpkens YW, de Fijter JW, Paul LC. The pathobiology of chronic allograft nephropathy: immune-mediated damage and accelerated aging. Kidney Int. 2004;65:1556-9.
26. Gingell-Littlejohn M, McGuinness D, McGlynn LM, Kingsmore D, Stevenson KS, Koppelstaetter C, et al. Pre-transplant CDKN2A expression in kidney biopsies predicts renal function and is a future component of donor scoring criteria. PLoS One. 2013;8:e68133.