Synergistic effect of RhBMP-2 and bFGF on ectopic osteogenesis in mice

Asian Pacific Journal of Tropical Medicine

Volumn 8, Issue 1, 2015, Pages 53-59

  Ma, Shu Yuan ^a   Feng, Zhi Qiang ^a   Lai, Ren Fa ^a   Zhou, Zhi Ying ^a   Yin, Zhong Da ^a  

^a THE FIRST AFFILIATED HOSPITAL OF JINAN UNIVERSITY   (China)

Author keywords

BFGF; BMP 2; Ectopic osteogenesis; Micro CT

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; CD34 ANTIGEN; FIBROBLAST GROWTH FACTOR 2; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE MASS; BONE REMODELING; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; CORTICAL THICKNESS (BONE); MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NEWBORN; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURFACE PROPERTY; THREE DIMENSIONAL IMAGING; TRABECULAR BONE;

EID: 84927734670     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1995-7645(14)60187-5     Document Type: Article

References (17)

1. Kim IS, Song YM, Cho TH, Park YD, Lee KB, Noh I, et al. In vitro response of primary human bone marrow stromal cells to recombinant human bone morphogenic protein-2 in the early and late stages of osteoblast differentiation. Dev Growth Differ 2008, 50(7):553-564.
2. Einhorn TA, Majeska RJ, Mohaideen A, Kagel EM, Bouxsein ML, Turek TJ, et al. A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair. J Bone Joint Surg Am 2003, 85-A(8):1425-1435.
3. Zhang X, Wang Y, Gao Y, Liu X, Bai T, Li M, et al. Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors. Int J Mol Med 2013, 21(8):9139. 9121.
4. Fujioka-Kobayashi M, Ota MS, Shimoda A, Nakahama K, Akiyoshi K, Miyamoto Y, et al. Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering. Biomaterials 2012, 33(30):7613-7620.
5. Ercolin ACM, Mkrtschjan M, Bionaz M, Jensen T, Wheeler MB Osteogenic activity of in house-produced porcine Bmp2 on adipose-derived stem cells. Reprod Fertility Dev 2013, 25(1):288.
6. Shi Q, Li Y, Sun J, Zhang H, Chen L, Chen B, et al. The osteogenesis of bacterial cellulose scaffold loaded with bone morphogenetic protein-2. Biomaterials 2012, 33(28):6644-6649.
7. Yang C, Liu Y, Li C, Zhang B Repair of mandibular defects by bone marrow stromal cells expressing the basic fibroblast growth factor transgene combined with multi-pore mineralized Bio-Oss. Mol Med Rep 2013, 7(1):99-104.
8. Qu D, Li JH, Li YB, Gao Y, Zuo Y, Hsu Y, et al. Angiogenesis and osteogenesis enhanced by bFGF ex vivo gene therapy for bone tissue engineering in reconstruction of calvarial defects. J Biomed Mater Res A 2011, 96(3):5435-5451.
9. Wodewotzky TI, Lima-Neto JF, Pereira-Júnior OC, Sudano MJ, Lima SA, Bersano PR, et al. In vitro cultivation of canine multipotent mesenchymal stromal cells on collagen membranes treated with hyaluronic acid for cell therapy and tissue regeneration. Braz J Med Biol Res 2012, 45(12):1157-1162.
10. Li Q, Liu T, Zhang L, Liu Y, Zhang W, Liu W, et al. The role of bFGF in down-regulating alpha-SMA expression of chondrogenically induced BMSCs and preventing the shrinkage of BMSC engineered cartilage. Biomaterials 2011, 32(21):4773-4781.
11. Varkey M, Kucharski C, Haque T, Sebald W, Uludağ H In vitro osteogenic response of rat bone marrow cells to bFGF and BMP-2 treatments. Clin Orthop Relat Res 2006, 443:113-123.
12. Wang L, Huang Y, Pan K, Jiang X, Liu C Osteogenic responses to different concentrations/ratios of BMP-2 and bFGF in bone formation. Ann Biomed Eng 2010, 38(1):77-87.
13. Li HY, Chang J Stimulation of proangiogenesis by calcium silicate bioactive ceramic. Acta Biomater 2013, 9(2):5379-5389.
14. Liu F, Zhang X, Yu X, Xu Y, Feng T, Ren D In vitro study in stimulating the secretion of angiogenic growth factors of strontium-doped calcium polyphosphate for bone tissue engineering. J Mater Sci-Mater Med 2011, 22(3):683-692.
15. Pu F, Wang E, Jiang H, Ren J Identification of polyoxometalates as inhibitors of basic fibroblast growth factor. Mol Biosys 2013, 9(1):113-120.
16. Zong A, Zhao T, Zhang Y, Song X, Shi Y, Cao H, et al. Anti-metastatic and anti-angiogenic activities of sulfated polysaccharide of Sepiella maindroni ink. Carbohydr Polym 2013, 91(1):403-409.
17. Farhat FS, Tfayli A, Fakhruddin N, Mahfouz R, Otrock ZK, Alameddine RS, et al. Expression, prognostic and predictive impact of VEGF and bFGF in non-small cell lung cancer. Crit Rev Oncol Hematol 2012, 84(2):149-160.