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Volumn 18, Issue 4, 2015, Pages 169-176

Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: A double blind, placebo, controlled randomized clinical trial

Author keywords

Antioxidants; Coenzyme Q10; Cytokines; IL 6; Inflammation; MMP 9; Multiple sclerosis; Randomized placebo controlled trial; Supplementation; TGF ; TNF

Indexed keywords

GELATINASE B; INTERLEUKIN 4; INTERLEUKIN 6; LYMPHOTOXIN; PLACEBO; TUMOR NECROSIS FACTOR ALPHA; UBIDECARENONE; BIOLOGICAL MARKER; MATRIX METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA; UBIQUINONE;

EID: 84927719564     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830513Y.0000000106     Document Type: Article
Times cited : (109)

References (42)
  • 2
    • 0034333099 scopus 로고    scopus 로고
    • Interferon-beta treatment in multiple sclerosis patients decreases the number of circulating T cells producing interferon-gamma and interleukin-4
    • 2 Furlan R, Bergami A, Lang R, Brambilla E, Franciotta D, Martinelli V, et al. Interferon-beta treatment in multiple sclerosis patients decreases the number of circulating T cells producing interferon-gamma and interleukin-4. J Neuroimmunol 2000; 111(1-2):86-92.
    • (2000) J Neuroimmunol , vol.111 , Issue.1-2 , pp. 86-92
    • Furlan, R.1    Bergami, A.2    Lang, R.3    Brambilla, E.4    Franciotta, D.5    Martinelli, V.6
  • 4
    • 81755179424 scopus 로고    scopus 로고
    • How do immune cells overcome the blood-brain barrier in multiple sclerosis?
    • 4 Larochelle C, Alvarez JI, Prat A. How do immune cells overcome the blood-brain barrier in multiple sclerosis? FEBS Lett 2011;585(23):3770-80.
    • (2011) FEBS Lett , vol.585 , Issue.23 , pp. 3770-3780
    • Larochelle, C.1    Alvarez, J.I.2    Prat, A.3
  • 5
    • 0032427976 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with copoly-mer-1 (Copaxone): Implicating mechanisms of Th1 to Th2/Th3 immune-deviation
    • 5 Miller A, Shapiro S, Gershtein R, Kinarty A, Rawashdeh H, Honigman S, et al. Treatment of multiple sclerosis with copoly-mer-1 (Copaxone): implicating mechanisms of Th1 to Th2/Th3 immune-deviation. J Neuroimmunol 1998;92(1-2):113-21.
    • (1998) J Neuroimmunol , vol.92 , Issue.1-2 , pp. 113-121
    • Miller, A.1    Shapiro, S.2    Gershtein, R.3    Kinarty, A.4    Rawashdeh, H.5    Honigman, S.6
  • 7
    • 70349780391 scopus 로고    scopus 로고
    • Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-ß1 expression
    • 7 Choi HK, Pokharel YR, Lim SC, Han HK, Ryu CS, Kim SK, et al. Inhibition of liver fibrosis by solubilized coenzyme Q10: role of Nrf2 activation in inhibiting transforming growth factor-ß1 expression. Toxicol Appl Pharmacol 2009;240(3): 377-84.
    • (2009) Toxicol Appl Pharmacol , vol.240 , Issue.3 , pp. 377-384
    • Choi, H.K.1    Pokharel, Y.R.2    Lim, S.C.3    Han, H.K.4    Ryu, C.S.5    Kim, S.K.6
  • 8
    • 79958002852 scopus 로고    scopus 로고
    • Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: A randomized controlled trial
    • 8 Dai YL, Luk TH, Yiu KH, Wang M, Yip P, Lee SWL, et al. Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial. Atherosclerosis 2011;216(2):395-401.
    • (2011) Atherosclerosis , vol.216 , Issue.2 , pp. 395-401
    • Dai, Y.L.1    Luk, T.H.2    Yiu, K.H.3    Wang, M.4    Yip, P.5    Lee, S.6
  • 9
    • 84862787110 scopus 로고    scopus 로고
    • Effects of coenzyme Q10 supplementation on inflammatory markers (High-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease
    • 9 Lee BJ, Huang YC, Chen SJ, Lin PT. Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease. Nutrition 2012;28(7-8):767-72.
    • (2012) Nutrition , vol.28 , Issue.7-8 , pp. 767-772
    • Lee, B.J.1    Huang, Y.C.2    Chen, S.J.3    Lin, P.T.4
  • 10
    • 70449529407 scopus 로고    scopus 로고
    • Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome
    • 10 Kumar A, Kaur H, Devi P, Mohan V. Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Therapeutics 2009;124(3):259-68.
    • (2009) Pharmacol Therapeutics , vol.124 , Issue.3 , pp. 259-268
    • Kumar, A.1    Kaur, H.2    Devi, P.3    Mohan, V.4
  • 11
    • 33645549258 scopus 로고    scopus 로고
    • Anti-inflammatory effects of CoQ10 and colorless carotenoids
    • 11 Fuller B, Smith D, Howerton A, Kern D. Anti-inflammatory effects of CoQ10 and colorless carotenoids. J Cosmet Dermatol 2006;5(1):30-8.
    • (2006) J Cosmet Dermatol , vol.5 , Issue.1 , pp. 30-38
    • Fuller, B.1    Smith, D.2    Howerton, A.3    Kern, D.4
  • 12
    • 0032555066 scopus 로고    scopus 로고
    • Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
    • 12 Matthews RT, Yang L, Browne S, Baik M, Beal MF. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci 1998;95(15):8892-7.
    • (1998) Proc Natl Acad Sci , vol.95 , Issue.15 , pp. 8892-8897
    • Matthews, R.T.1    Yang, L.2    Browne, S.3    Baik, M.4    Beal, M.F.5
  • 13
    • 60849106971 scopus 로고    scopus 로고
    • In vitro effects of the reduced form of coenzyme Q10 on secretion levels of TNF-a and chemokines in response to LPS in the human monocytic cell line THP-1
    • 13 Schmelzer C, Lorenz G, Rimbach G, Döring F. In vitro effects of the reduced form of coenzyme Q10 on secretion levels of TNF-a and chemokines in response to LPS in the human monocytic cell line THP-1. J Clin Biochem Nutr 2009;44(1):62.
    • (2009) J Clin Biochem Nutr , vol.44 , Issue.1 , pp. 62
    • Schmelzer, C.1    Lorenz, G.2    Rimbach, G.3    Döring, F.4
  • 14
    • 84855221555 scopus 로고    scopus 로고
    • Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity
    • 14 Fouad AA, Jresat I. Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity. Environ Toxicol Pharmacol 2012;33(2):158-67.
    • (2012) Environ Toxicol Pharmacol , vol.33 , Issue.2 , pp. 158-167
    • Fouad, A.A.1    Jresat, I.2
  • 16
    • 78649485564 scopus 로고    scopus 로고
    • Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model
    • 16 Bahar M, Khaghani S, Pasalar P, Paknejad M, Khorramizadeh MR, Mirmiranpour H, et al. Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model. Nutr J 2010;9(62):1475-2891.
    • (2010) Nutr J , vol.9 , Issue.62 , pp. 1475-2891
    • Bahar, M.1    Khaghani, S.2    Pasalar, P.3    Paknejad, M.4    Khorramizadeh, M.R.5    Mirmiranpour, H.6
  • 17
    • 0036014862 scopus 로고    scopus 로고
    • OkCu ZL Serum levels of antioxidant vitamins and lipid peroxidation in multiple sclerosis
    • 17 Besler HIT, Comoglu SC, OkCu ZL Serum levels of antioxidant vitamins and lipid peroxidation in multiple sclerosis. Nutr Neurosci 2002;5(3):215-20.
    • (2002) Nutr Neurosci , vol.5 , Issue.3 , pp. 215-220
    • Besler, H.1    Comoglu, S.C.2
  • 19
    • 84885943179 scopus 로고    scopus 로고
    • Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis
    • 19 Sanoobar M, Eghtesadi S, Azimi A, Khalili M, Jazayeri S, Gohari MR. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with relapsing-remitting multiple sclerosis. Int J Neurosci 2013; 123(11):776-82.
    • (2013) Int J Neurosci , vol.123 , Issue.11 , pp. 776-782
    • Sanoobar, M.1    Eghtesadi, S.2    Azimi, A.3    Khalili, M.4    Jazayeri, S.5    Gohari, M.R.6
  • 20
    • 84927753312 scopus 로고    scopus 로고
    • SahraianMA, et al. Effect oflipoic acid consumption onoxi-dative stress among multiple sclerosis patients: A randomized controlled clinical trial
    • 20 Khalili M, Eghtesadi S, Mirshafiey A, Eskandari G, Sanoobar M, SahraianMA, et al. Effect oflipoic acid consumption onoxi-dative stress among multiple sclerosis patients: a randomized controlled clinical trial. Nutr Neurosci 2013;23485514.
    • (2013) Nutr Neurosci , pp. 23485514
    • Khalili, M.1    Eghtesadi, S.2    Mirshafiey, A.3    Eskandari, G.4    Sanoobar, M.5
  • 21
    • 84927753311 scopus 로고    scopus 로고
    • Is the lipoic acid consumption affect on the cytokine profile in the multiple sclerosis patients: A double blind, placebo, controlled randomized clinical trial
    • 21 Khalili M, Izadi V, Eghtesadi S, Mirshafiey A, Sahraian MA, Motevalian A, et al. Is the lipoic acid consumption affect on the cytokine profile in the multiple sclerosis patients: a double blind, placebo, controlled randomized clinical trial. Neuroimmunomodulation 2013;DOI: 356145.
    • (2013) Neuroimmunomodulation
    • Khalili, M.1    Izadi, V.2    Eghtesadi, S.3    Mirshafiey, A.4    Sahraian, M.A.5    Motevalian, A.6
  • 22
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis
    • 22 McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50(1): 121-7.
    • (2001) Ann Neurol , vol.50 , Issue.1 , pp. 121-127
    • McDonald, W.I.1    Compston, A.2    Edan, G.3    Goodkin, D.4    Hartung, H.P.5    Lublin, F.D.6
  • 23
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course ofmultiple sclerosis results of an international survey
    • 23 Lublin FD, Reingold SC. Defining the clinical course ofmultiple sclerosis results of an international survey. Neurology 1996;46(4): 907-11.
    • (1996) Neurology , vol.46 , Issue.4 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 24
    • 0033956180 scopus 로고    scopus 로고
    • Effect of coenzyme Q10 on experimental atherosclerosis and chemical composition and quality of atheroma in rabbits
    • 24 Singh RB, Shinde SN, Chopra RK, Niaz MA, Thakur AS, Onouchi Z. Effect of coenzyme Q10 on experimental atherosclerosis and chemical composition and quality of atheroma in rabbits. Atherosclerosis 2000;148(2):275.
    • (2000) Atherosclerosis , vol.148 , Issue.2 , pp. 275
    • Singh, R.B.1    Shinde, S.N.2    Chopra, R.K.3    Niaz, M.A.4    Thakur, A.S.5    Onouchi, Z.6
  • 26
    • 35848957483 scopus 로고    scopus 로고
    • Multifaceted aspects of inflammation in multiple sclerosis: The role of microglia
    • 26 Muzio L, Martino G, Furlan R. Multifaceted aspects of inflammation in multiple sclerosis: the role of microglia. J Neuroimmunol 2007;191(1):39-44.
    • (2007) J Neuroimmunol , vol.191 , Issue.1 , pp. 39-44
    • Muzio, L.1    Martino, G.2    Furlan, R.3
  • 27
    • 0032716144 scopus 로고    scopus 로고
    • Axonal degeneration in the pathogenesis of multiple sclerosis
    • 27 Silber E, Sharief MK. Axonal degeneration in the pathogenesis of multiple sclerosis. J Neurol Sci 1999;170(1):11-18.
    • (1999) J Neurol Sci , vol.170 , Issue.1 , pp. 11-18
    • Silber, E.1    Sharief, M.K.2
  • 28
    • 77954256293 scopus 로고    scopus 로고
    • Coenzyme Q10 secreases TNF-ALPHA. And IL-2 secretion by human peripheral blood mononuclear cells
    • 28 Bessler H, Bergman M, Blumberger N, Djaldetti M, Salman H. Coenzyme Q10 secreases TNF-ALPHA. and IL-2 secretion by human peripheral blood mononuclear cells. J Nutr Sci Vitaminol 2010;56(1):77-81.
    • (2010) J Nutr Sci Vitaminol , vol.56 , Issue.1 , pp. 77-81
    • Bessler, H.1    Bergman, M.2    Blumberger, N.3    Djaldetti, M.4    Salman, H.5
  • 29
    • 60249097822 scopus 로고    scopus 로고
    • Coadministration of coenzyme Q prevents rosi-glitazone-induced adipogenesis in ob/ob mice
    • 29 Carmona MC, Lefebvre P, Lefebvre B, Galinier A, Bénani A, Jeanson Y, et al. Coadministration of coenzyme Q prevents rosi-glitazone-induced adipogenesis in ob/ob mice. Int J Obes 2009; 33(2):204-11.
    • (2009) Int J Obes , vol.33 , Issue.2 , pp. 204-211
    • Carmona, M.C.1    Lefebvre, P.2    Lefebvre, B.3    Galinier, A.4    Bénani, A.5    Jeanson, Y.6
  • 30
    • 77954141949 scopus 로고    scopus 로고
    • Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice
    • 30 Fouad AA, Al-Sultan AI, Refaie SM, Yacoubi MT. Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice. Toxicology 2010;274(1):49-56.
    • (2010) Toxicology , vol.274 , Issue.1 , pp. 49-56
    • Fouad, A.A.1    Al-Sultan, A.I.2    Refaie, S.M.3    Yacoubi, M.T.4
  • 32
    • 70349767934 scopus 로고    scopus 로고
    • Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice
    • 32 Sohet FM, Neyrinck AM, Pachikian BD, de Backer FC, Bindels LB, Niklowitz P, et al. Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice. Biochem Pharmacol 2009;78(11): 1391-400.
    • (2009) Biochem Pharmacol , vol.78 , Issue.11 , pp. 1391-1400
    • Sohet, F.M.1    Neyrinck, A.M.2    Pachikian, B.D.3    De Backer, F.C.4    Bindels, L.B.5    Niklowitz, P.6
  • 33
    • 58149377630 scopus 로고    scopus 로고
    • Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo
    • 33 Inui M, Ooe M, Fujii K, Matsunaka H, Yoshida M, Ichihashi M. Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo. Biofactors 2008;32(1-4):237-43.
    • (2008) Biofactors , vol.32 , Issue.1-4 , pp. 237-243
    • Inui, M.1    Ooe, M.2    Fujii, K.3    Matsunaka, H.4    Yoshida, M.5    Ichihashi, M.6
  • 34
    • 43449128829 scopus 로고    scopus 로고
    • Anti-angiogenic potential of Coenzyme Q10, riboflavin and niacin in breast cancer patients undergoing tamoxifen therapy
    • 34 Premkumar VG, Yuvaraj S, Sathish S, Shanthi P, Sachdanandam P. Anti-angiogenic potential of Coenzyme Q10, riboflavin and niacin in breast cancer patients undergoing tamoxifen therapy. Vase Pharmacol 2008;48(4): 191-201.
    • (2008) Vase Pharmacol , vol.48 , Issue.4 , pp. 191-201
    • Premkumar, V.G.1    Yuvaraj, S.2    Sathish, S.3    Shanthi, P.4    Sachdanandam, P.5
  • 35
    • 76649119785 scopus 로고    scopus 로고
    • Effects of coenzyme Q10 supplementation on plasma adiponeetin, interleukin-6, and tumor necrosis factor-alpha levels in men
    • 35 Gokbel H, Gergerlioglu HS, Okudan N, Gul I, Buyukbas S, Belviranli M. Effects of coenzyme Q10 supplementation on plasma adiponeetin, interleukin-6, and tumor necrosis factor-alpha levels in men. J Med Food 2010;13(1):216-18.
    • (2010) J Med Food , vol.13 , Issue.1 , pp. 216-218
    • Gokbel, H.1    Gergerlioglu, H.S.2    Okudan, N.3    Gul, I.4    Buyukbas, S.5    Belviranli, M.6
  • 36
    • 18044382584 scopus 로고    scopus 로고
    • Cytokines in multiple sclerosis: From bench to bedside
    • 36 Imitola J, Chitnis T, Khoury SJ. Cytokines in multiple sclerosis: from bench to bedside. Pharmacol Therapeutics 2005;106(2): 163-77.
    • (2005) Pharmacol Therapeutics , vol.106 , Issue.2 , pp. 163-177
    • Imitola, J.1    Chitnis, T.2    Khoury, S.J.3
  • 37
    • 78650967701 scopus 로고    scopus 로고
    • TGF-beta signaling is altered in the peripheral blood of subjects with multiple sclerosis
    • 37 Meoli EM, Oh U, Grant CW, Jacobson S. TGF-beta signaling is altered in the peripheral blood of subjects with multiple sclerosis. J Neuroimmunol 2011;230(1-2):164-8.
    • (2011) J Neuroimmunol , vol.230 , Issue.1-2 , pp. 164-168
    • Meoli, E.M.1    Oh, U.2    Grant, C.W.3    Jacobson, S.4
  • 38
    • 0036088187 scopus 로고    scopus 로고
    • In vivo effect of interferon-ß 1a on interleukin-12 and TGF-ß1 cytokines in patients with relap-sing-remitting multiple sclerosis
    • 38 Losy J, Michalowska-Wender G. In vivo effect of interferon-ß 1a on interleukin-12 and TGF-ß1 cytokines in patients with relap-sing-remitting multiple sclerosis. Acta Neurol Scand 2002; 106(1):44-6.
    • (2002) Acta Neurol Scand , vol.106 , Issue.1 , pp. 44-46
    • Losy, J.1    Michalowska-Wender, G.2
  • 39
    • 84886596028 scopus 로고    scopus 로고
    • Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol-induced neuropathic pain
    • 39 Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL. Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol-induced neuropathic pain. Fundam Clin Pharmacol 2013;27(6):603-22.
    • (2013) Fundam Clin Pharmacol , vol.27 , Issue.6 , pp. 603-622
    • Kandhare, A.D.1    Ghosh, P.2    Ghule, A.E.3    Bodhankar, S.L.4
  • 40
    • 0032126914 scopus 로고    scopus 로고
    • Elevated serum levels of IFN-gamma, IL-4 and TNF-alpha/unelevated serum levels of IL-10 in patients with demyelinating diseases during the acute stage
    • 40 Hohnoki K, Inoue A, Koh CS. Elevated serum levels of IFN-gamma, IL-4 and TNF-alpha/unelevated serum levels of IL-10 in patients with demyelinating diseases during the acute stage. J Neuroimmunol 1998;87(1-2):27-32.
    • (1998) J Neuroimmunol , vol.87 , Issue.1-2 , pp. 27-32
    • Hohnoki, K.1    Inoue, A.2    Koh, C.S.3
  • 42
    • 0034749944 scopus 로고    scopus 로고
    • Matrix metallo-proteinases: Multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis
    • 42 Leppert D, Lindberg RL, Kappos L, Leib SL. Matrix metallo-proteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis. Brain Res Brain Res Rev 2001;36(2-3):249-57.
    • (2001) Brain Res Brain Res Rev , vol.36 , Issue.2-3 , pp. 249-257
    • Leppert, D.1    Lindberg, R.L.2    Kappos, L.3    Leib, S.L.4


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