Stereoselective synthesis of the halaven C14-C26 fragment from D-quinic acid: Crystallization-induced diastereoselective transformation of an α-methyl nitrile

Angewandte Chemie - International Edition

Volumn 54, Issue 17, 2015, Pages 5108-5111

  Belanger, Francis ^b   Chase, Charles E ^a   Endo, Atsushi ^a   Fang, Francis G ^a   Li, Jing ^a   Mathieu, Steven R ^a   Wilcoxen, Annie Z ^c   Zhang, Huiming ^d  

^a EISAI INC   (United States)

^b PCAS BioMatrix   (Canada)

^c AMGEN INC   (United States)

^d Johnson Matthey Pharmaceutical Materials Inc   (United States)

Author keywords

antitumor agents; asymmetric synthesis; chiral pool; green chemistry; total synthesis

Indexed keywords

CYANIDES; REACTION INTERMEDIATES; STEREOCHEMISTRY;

ANTI-TUMOR AGENTS; ASYMMETRIC SYNTHESIS; CHIRAL POOL; GREEN CHEMISTRY; TOTAL SYNTHESIS;

STEREOSELECTIVITY;

EID: 84927710989     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201501143     Document Type: Article

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