Testosterone regulates thyroid cancer progression by modifying tumor suppressor genes and tumor immunity

Carcinogenesis

Volumn 36, Issue 4, 2014, Pages 420-428

  Zhang, Lisa J ^a   Xiong, Yin ^a   Nilubol, Naris ^a   He, Mei ^a   Bommareddi, Swaroop ^a   Zhu, Xuguang ^a   Jia, Li ^a   Xiao, Zhen ^b   Park, Jeong Won ^a   Xu, Xia ^b   Patel, Dhaval ^a   Willingham, Mark C ^a   Cheng, Sheue Yann ^a   Kebebew, Electron ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; RANTES; SEX HORMONE; TESTOSTERONE; CCL5 PROTEIN, HUMAN; GLIPR1 PROTEIN, HUMAN; MEMBRANE PROTEIN; NERVE PROTEIN; SFRP1 PROTEIN, HUMAN; SIGNAL PEPTIDE; SMALL INTERFERING RNA; THYROID HORMONE RECEPTOR BETA; TUMOR PROTEIN;

ADVANCED CANCER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER INCIDENCE; CANCER INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GENDER; GENE EXPRESSION PROFILING; GLIPR1 GENE; IMMUNOCOMPETENT CELL; IMMUNOSTIMULATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SFRP1 GENE; THYROID CANCER; TRANSGENIC MOUSE; TUMOR IMMUNITY; TUMOR SUPPRESSOR GENE; ADENOCARCINOMA; ANIMAL; BIOSYNTHESIS; CASTRATION; CD8+ T LYMPHOCYTE; CELL LINE; CELL PROLIFERATION; DISEASE COURSE; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; METABOLISM; PATHOLOGY; RNA INTERFERENCE; SECRETION (PROCESS); SEX RATIO; THYROID TUMOR;

ADENOCARCINOMA, FOLLICULAR; ANIMALS; CASTRATION; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL PROLIFERATION; CHEMOKINE CCL5; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION PROFILING; GENES, TUMOR SUPPRESSOR; HEK293 CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SEX DISTRIBUTION; TESTOSTERONE; THYROID HORMONE RECEPTORS BETA; THYROID NEOPLASMS;

EID: 84927587080     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgv001     Document Type: Article

References (29)

1. Fajkovic, H. et al. (2011) Impact of gender on bladder cancer incidence, staging, and prognosis. World J. Urol., 29, 457-463.
2. Rahbari, R. et al. (2010) Thyroid cancer gender disparity. Future Oncol., 6, 1771-1779.
3. Mulligan, C.R. et al. (2006) Unlimited access to care: effect on racial disparity and prognostic factors in lung cancer. Cancer Epidemiol. Biomarkers Prev., 15, 25-31.
4. Davies, L. et al. (2006) Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA, 295, 2164-2167.
5. Nilubol, N. et al. (2013) Multivariate analysis of the relationship between male sex, disease-specific survival, and features of tumor aggressiveness in thyroid cancer of follicular cell origin. Thyroid, 23, 695-702.
6. Aschebrook-Kilfoy, B. et al. (2011) Diabetes and thyroid cancer risk in the National Institutes of Health-AARP Diet and Health Study. Thyroid, 21, 957-963.
7. Shih, S.R. et al. (2012) Diabetes and thyroid cancer risk: literature review. Exp. Diabetes Res., 2012, 578285.
8. Kitahara, C.M. et al. (2011) Obesity and thyroid cancer risk among U.S. men and women: a pooled analysis of five prospective studies. Cancer Epidemiol. Biomarkers Prev., 20, 464-472.
9. Ruggieri, A. et al. (2010) Cellular and molecular mechanisms involved in hepatocellular carcinoma gender disparity. Int. J. Cancer, 127, 499-504.
10. Nakagawa, H. et al. (2009) Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences. Int. J. Cancer, 125, 2264-2269.
11. Naugler, W.E. et al. (2007) Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science, 317, 121-124.
12. Suzuki, H. et al. (2002) Mice with a mutation in the thyroid hormone receptor beta gene spontaneously develop thyroid carcinoma: a mouse model of thyroid carcinogenesis. Thyroid, 12, 963-969.
13. Lapteva, N. et al. (2010) CCL5 as an adjuvant for cancer immunotherapy. Expert Opin. Biol. Ther., 10, 725-733.
14. Kaneshige, M. et al. (2000) Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone. Proc. Natl Acad. Sci. USA, 97, 13209-13214.
15. Xu, X. et al. (2007) Quantitative measurement of endogenous estrogens and estrogen metabolites in human serum by liquid chromatographytandem mass spectrometry. Anal. Chem., 79, 7813-7821.
16. Klug, F. et al. (2013) Low-dose irradiation programs macrophage differentiation to an iNOS+/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell, 24, 589-602.
17. Li, L. et al. (2011) GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction. Cancer Res., 71, 7694-7704.
18. Satoh, T. et al. (2003) Adenoviral vector-mediated mRTVP-1 gene therapy for prostate cancer. Hum. Gene Ther., 14, 91-101.
19. Ren, C. et al. (2002) mRTVP-1, a novel p53 target gene with proapoptotic activities. Mol. Cell. Biol., 22, 3345-3357.
20. Li, L. et al. (2008) Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling. Cancer Res., 68, 434-443.
21. Sonpavde, G. et al. (2011) GLIPR1 tumor suppressor gene expressed by adenoviral vector as neoadjuvant intraprostatic injection for localized intermediate or high-risk prostate cancer preceding radical prostatectomy. Clin. Cancer Res., 17, 7174-7182.
22. Li, L. et al. (2013) Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2. Mol. Oncol., 7, 484-496.
23. Karantanos, T. et al. (2014) Systemic GLIPR1-ΔTM protein as a novel therapeutic approach for prostate cancer. Int. J. Cancer, 134, 2003-2013.
24. Chow, M.T. et al. (2012) Inflammation and immune surveillance in cancer. Semin. Cancer Biol., 22, 23-32.
25. Guarino, V. et al. (2010) Thyroid cancer and inflammation. Mol. Cell. Endocrinol., 321, 94-102.
26. Okayasu, I. et al. (1995) Association of chronic lymphocytic thyroiditis and thyroid papillary carcinoma. A study of surgical cases among Japanese, and white and African Americans. Cancer, 76, 2312-2318.
27. Kebebew, E. et al. (2001) Coexisting chronic lymphocytic thyroiditis and papillary thyroid cancer revisited. World J. Surg., 25, 632-637.
28. Fiumara, A. et al. (1997) In situ evidence of neoplastic cell phagocytosis by macrophages in papillary thyroid cancer. J. Clin. Endocrinol. Metab., 82, 1615-1620.
29. Kim, W.G. et al. (2013) Reactivation of the silenced thyroid hormone receptor β gene expression delays thyroid tumor progression. Endocrinology, 154, 25-35.