Effects of branched-chain amino acids supplementation on both plasma amino acids concentration and muscle energetics changes resulting from muscle damage: A randomized placebo controlled trial

Clinical Nutrition

Volumn 35, Issue 1, 2016, Pages 83-94

  Fouré, Alexandre ^a   Nosaka, Kazunori ^b   Gastaldi, Marguerite ^c   Mattei, Jean Pierre ^a,d   Boudinet, Hélène ^e   Guye, Maxime ^a,e   Vilmen, Christophe ^a   Le Fur, Yann ^a   Bendahan, David ^a   Gondin, Julien ^a  

^a University of Aix Marseille   (France)

^b EDITH COWAN UNIVERSITY   (Australia)

^c AIX MARSEILLE UNIVERSITY   (France)

^d HÔPITAL SAINTE MARGUERITE   (France)

^e TIMONE HOSPITAL   (France)

Author keywords

Double blind randomized placebo controlled trial; Exercise induced muscle damage; Magnetic resonance spectroscopy

Indexed keywords

ALANINE; AMINO ACID; BRANCHED CHAIN AMINO ACID; CREATINE PHOSPHATE; GLYCINE; HISTIDINE; PHENYLALANINE; PHOSPHATE; PLACEBO; TYROSINE; MUSCLE PROTEIN;

ADULT; AMINO ACID ANALYSIS; AMINO ACID BLOOD LEVEL; ARTICLE; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ELECTROSTIMULATION; EXERCISE; EXERCISE INDUCED MUSCLE DAMAGE; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE INJURY; MUSCLE ISOMETRIC CONTRACTION; MUSCLE METABOLISM; NEUROMUSCULAR ELECTROSTIMULATION; NORMAL HUMAN; PH; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; REST; BLOOD; BODY MASS; BODY WEIGHT; DIETARY SUPPLEMENT; DRUG EFFECTS; KNEE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; SKELETAL MUSCLE; YOUNG ADULT;

ADULT; ALANINE; AMINO ACIDS, BRANCHED-CHAIN; BODY MASS INDEX; BODY WEIGHT; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; EXERCISE; GLYCINE; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; KNEE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; PHENYLALANINE; PHOSPHATES; PHOSPHOCREATINE; TYROSINE; YOUNG ADULT;

EID: 84927545861     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2015.03.014     Document Type: Article

References (59)

1. Harper A.E., Miller R.H., Block K.P. Branched-chain amino acid metabolism. Annu Rev Nutr 1984, 4:409-454.
2. Rennie M.J., Tipton K.D. Protein and amino acid metabolism during and after exercise and the effects of nutrition. Annu Rev Nutr 2000, 20:457-483.
3. Spriet L. Anaerobic metabolism during exercise. Exercise metabolism 2006, 7-27. Human Kinetics, Champaign, IL. 2nd ed. M. Hargreaves, L. Spriet (Eds.).
4. Valerio A., D'Antona G., Nisoli E. Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective. Aging 2011, 3:464-478.
5. Shimomura Y., Kobayashi H., Mawatari K., Akita K., Inaguma A., Watanabe S., et al. Effects of squat exercise and branched-chain amino acid supplementation on plasma free amino acid concentrations in young women. J Nutr Sci Vitaminol (Tokyo) 2009, 55:288-291.
6. Matthews D.E. Observations of branched-chain amino acid administration in humans. J Nutr 2005, 135:1580S-1584S.
7. Mattick J.S., Kamisoglu K., Ierapetritou M.G., Androulakis I.P., Berthiaume F. Branched-chain amino acid supplementation: impact on signaling and relevance to critical illness. Wiley Interdiscip Rev Syst Biol Med 2013, 5:449-460.
8. Kimball S.R., Jefferson L.S. Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr 2006, 136:227S-231S.
9. Wang X., Proud C.G. The mTOR pathway in the control of protein synthesis. Physiol (Bethesda) 2006, 21:362-369.
10. D'Antona G., Ragni M., Cardile A., Tedesco L., Dossena M., Bruttini F., et al. Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice. Cell Metab 2010, 12:362-372.
11. Tatpati L.L., Irving B.A., Tom A., Bigelow M.L., Klaus K., Short K.R., et al. The effect of branched chain amino acids on skeletal muscle mitochondrial function in young and elderly adults. J Clin Endocrinol Metab 2010, 95:894-902.
12. Doi J., Shiraishi K., Haida M., Matsuzaki S. Abnormality of energy metabolism in the skeletal muscle of patients with liver cirrhosis and changes under administration of glucose and branched-chain amino acids. Tokai J Exp Clin Med 2004, 29:191-198.
13. Kutsuzawa T., Kurita D., Haida M. Acute effects of branched-chain amino acids on muscle pH during exercise. Adv Exerc Sports Physiol 2011, 16:101-107.
14. Jackman S.R., Witard O.C., Jeukendrup A.E., Tipton K.D. Branched-chain amino acid ingestion can ameliorate soreness from eccentric exercise. Med Sci Sports Exerc 2010, 42:962-970.
15. Ra S.G., Miyazaki T., Ishikura K., Nagayama H., Komine S., Nakata Y., et al. Combined effect of branched-chain amino acids and taurine supplementation on delayed onset muscle soreness and muscle damage in high-intensity eccentric exercise. J Int Soc Sports Nutr 2013, 10:51.
16. Shimomura Y., Inaguma A., Watanabe S., Yamamoto Y., Muramatsu Y., Bajotto G., et al. Branched-chain amino acid supplementation before squat exercise and delayed-onset muscle soreness. Int J Sport Nutr Exerc Metab 2010, 20:236-244.
17. Areces F., Salinero J.J., Abian-Vicen J., Gonzalez-Millan C., Gallo-Salazar C., Ruiz-Vicente D., et al. A 7-day oral supplementation with branched-chain amino acids was ineffective to prevent muscle damage during a marathon. Amino Acids 2014, 46:1169-1176.
18. Howatson G., Hoad M., Goodall S., Tallent J., Bell P.G., French D.N. Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study. J Int Soc Sports Nutr 2012, 9:20.
19. Greer B.K., Woodard J.L., White J.P., Arguello E.M., Haymes E.M. Branched-chain amino acid supplementation and indicators of muscle damage after endurance exercise. Int J Sport Nutr Exerc Metab 2007, 17:595-607.
20. Sharp C.P., Pearson D.R. Amino acid supplements and recovery from high-intensity resistance training. J Strength Cond Res 2010, 24:1125-1130.
21. Nosaka K., Sacco P., Mawatari K. Effects of amino acid supplementation on muscle soreness and damage. Int J Sport Nutr Exerc Metab 2006, 16:620-635.
22. Knechtle B., Mrazek C., Wirth A., Knechtle P., Rust C.A., Senn O., et al. Branched-chain amino acid supplementation during a 100-km ultra-marathon-a randomized controlled trial. J Nutr Sci Vitaminol (Tokyo) 2012, 58:36-44.
23. Fouré A., Duhamel G., Wegrzyk J., Boudinet H., Mattei J.P., Le Troter A., et al. Heterogeneity of muscle damage induced by electrostimulation: a multimodal MRI study. Med Sci Sports Exerc 2015, 47:166-175.
24. Hultman E., Sjoholm H., Jaderholm-Ek I., Krynicki J. Evaluation of methods for electrical stimulation of human skeletal muscle in situ. Pflugers Arch 1983, 398:139-141.
25. Mackey A.L., Bojsen-Moller J., Qvortrup K., Langberg H., Suetta C., Kalliokoski K.K., et al. Evidence of skeletal muscle damage following electrically stimulated isometric muscle contractions in humans. J Appl Physiol 2008, 105:1620-1627.
26. Fouré A., Wegrzyk J., Le Fur Y., Mattei J.P., Boudinet H., Vilmen C., et al. Impaired mitochondrial function and reduced energy cost as a result of muscle damage. Med Sci Sports Exerc June 2015, 47:6. 10.1249/MSS.0000000000000523.
27. Blomstrand E., Celsing F., Newsholme E.A. Changes in plasma concentrations of aromatic and branched-chain amino acids during sustained exercise in man and their possible role in fatigue. Acta Physiol Scand 1988, 133:115-121.
28. Essen-Gustavsson B., Blomstrand E. Effect of exercise on concentrations of free amino acids in pools of type I and type II fibres in human muscle with reduced glycogen stores. Acta Physiol Scand 2002, 174:275-281.
29. Blomstrand E., Andersson S., Hassmen P., Ekblom B., Newsholme E.A. Effect of branched-chain amino acid and carbohydrate supplementation on the exercise-induced change in plasma and muscle concentration of amino acids in human subjects. Acta Physiol Scand 1995, 153:87-96.
30. Blomstrand E., Ek S., Newsholme E.A. Influence of ingesting a solution of branched-chain amino acids on plasma and muscle concentrations of amino acids during prolonged submaximal exercise. Nutrition 1996, 12:485-490.
31. Blomstrand E., Hassmen P., Ekblom B., Newsholme E.A. Administration of branched-chain amino acids during sustained exercise-effects on performance and on plasma concentration of some amino acids. Eur J Appl Physiol Occup Physiol 1991, 63:83-88.
32. Blomstrand E., Newsholme E.A. Effect of branched-chain amino acid supplementation on the exercise-induced change in aromatic amino acid concentration in human muscle. Acta Physiol Scand 1992, 146:293-298.
33. Blomstrand E., Saltin B. BCAA intake affects protein metabolism in muscle after but not during exercise in humans. Am J Physiol Endocrinol Metab 2001, 281:E365-E374.
34. Blomstrand E., Essen-Gustavsson B. Changes in amino acid concentration in plasma and type I and type II fibres during resistance exercise and recovery in human subjects. Amino Acids 2009, 37:629-636.
35. van Hall G., MacLean D.A., Saltin B., Wagenmakers A.J. Mechanisms of activation of muscle branched-chain alpha-keto acid dehydrogenase during exercise in man. J Physiol 1996, 494(Pt 3):899-905.
36. Layec G., Bringard A., Le Fur Y., Vilmen C., Micallef J.P., Perrey S., et al. Reproducibility assessment of metabolic variables characterizing muscle energetics in vivo: a 31P-MRS study. Magn Reson Med 2009, 62:840-854.
37. Zhang Y., Kobayashi H., Mawatari K., Sato J., Bajotto G., Kitaura Y., et al. Effects of branched-chain amino acid supplementation on plasma concentrations of free amino acids, insulin, and energy substrates in young men. J Nutr Sci Vitaminol (Tokyo) 2011, 57:114-117.
38. Fouré A., Nosaka K., Wegrzyk J., Duhamel G., Le Troter A., Boudinet H., et al. Time course of central and peripheral alterations after isometric neuromuscular electrical stimulation-induced muscle damage. PLoS One 2014, 9:e107298.
39. Vanhamme L., van den Boogaart A., Van Huffel S. Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson 1997, 129:35-43.
40. Le Fur Y., Nicoli F., Guye M., Confort-Gouny S., Cozzone P.J., Kober F. Grid-free interactive and automated data processing for MR chemical shift imaging data. MAGMA 2010, 23:23-30.
41. Kemp G.J., Meyerspeer M., Moser E. Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: a quantitative review. NMR Biomed 2007, 20:555-565.
42. Moon R.B., Richards J.H. Determination of intracellular pH by 31P magnetic resonance. J Biol Chem 1973, 248:7276-7278.
43. Walter G., Vandenborne K., Elliott M., Leigh J.S. In vivo ATP synthesis rates in single human muscles during high intensity exercise. J Physiol 1999, 519:901-910.
44. Layec G., Bringard A., Vilmen C., Micallef J.P., Le Fur Y., Perrey S., et al. Does oxidative capacity affect energy cost? an in vivo MR investigation of skeletal muscle energetics. Eur J Appl Physiol 2009, 106:229-242.
45. Jubeau M., Sartorio A., Marinone P.G., Agosti F., Van Hoecke J., Nosaka K., et al. Comparison between voluntary and stimulated contractions of the quadriceps femoris for growth hormone response and muscle damage. J Appl Physiol 2008, 104:75-81.
46. Aldayel A., Jubeau M., McGuigan M.R., Nosaka K. Less indication of muscle damage in the second than initial electrical muscle stimulation bout consisting of isometric contractions of the knee extensors. Eur J Appl Physiol 2010, 108:709-717.
47. Clarkson P.M., Hubal M.J. Exercise-induced muscle damage in humans. Am J Phys Med Rehabil 2002, 81:S52-S69.
48. Gibala M.J. Effect of exercise on skeletal muscle protein and amino acid metabolism in humans. Exercise metabolism 2006, 137-161. Human Kinetics, Champaign, IL. 2nd ed. M. Hargreaves, L. Spriet (Eds.).
49. Rutten E.P., Engelen M.P., Schols A.M., Deutz N.E. Skeletal muscle glutamate metabolism in health and disease: state of the art. Curr Opin Clin Nutr Metab Care 2005, 8:41-51.
50. Haymond M.W., Miles J.M. Branched chain amino acids as a major source of alanine nitrogen in man. Diabetes 1982, 31:86-89.
51. Garber A.J., Karl I.E., Kipnis D.M. Alanine and glutamine synthesis and release from skeletal muscle. II. The precursor role of amino acids in alanine and glutamine synthesis. J Biol Chem 1976, 251:836-843.
52. McCully K., Posner J. Measuring exercise-induced adaptations and injury with magnetic resonance spectroscopy. Int J Sports Med 1992, 13:S147-S149.
53. Davies R.C., Eston R.G., Fulford J., Rowlands A.V., Jones A.M. Muscle damage alters the metabolic response to dynamic exercise in humans: a 31P-MRS study. J Appl Physiol 2011, 111:782-790.
54. Dolezal B.A., Potteiger J.A., Jacobsen D.J., Benedict S.H. Muscle damage and resting metabolic rate after acute resistance exercise with an eccentric overload. Med Sci Sports Exerc 2000, 32:1202-1207.
55. Tee J.C., Bosch A.N., Lambert M.I. Metabolic consequences of exercise-induced muscle damage. Sports Med 2007, 37:827-836.
56. Welle S., Nair K.S. Relationship of resting metabolic rate to body composition and protein turnover. Am J Physiol 1990, 258:E990-E998.
57. Yeung E.W., Bourreau J.P., Allen D.G., Ballard H.J. Effect of eccentric contraction-induced injury on force and intracellular pH in rat skeletal muscles. J Appl Physiol 2002, 92:93-99.
58. Roussel M., Bendahan D., Mattei J.P., Le Fur Y., Cozzone P.J. 31P magnetic resonance spectroscopy study of phosphocreatine recovery kinetics in skeletal muscle: the issue of intersubject variability. Biochim Biophys Acta 2000, 1457:18-26.
59. Bendahan D., Kemp G.J., Roussel M., Fur Y.L., Cozzone P.J. ATP synthesis and proton handling in muscle during short periods of exercise and subsequent recovery. J Appl Physiol 2003, 94:2391-2397.