Folate supplements for stroke prevention: Targeted trial trumps the rest

JAMA - Journal of the American Medical Association

Volumn 313, Issue 13, 2015, Pages 1321-1322

  Stampfer, Meir ^a,b   Willett, Walter ^a,b  

^a CHANNING LABORATORY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENALAPRIL; ENALAPRIL PLUS FOLIC ACID; FOLIC ACID; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); UNCLASSIFIED DRUG; ANTIHYPERTENSIVE AGENT; VITAMIN B COMPLEX;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; DIET SUPPLEMENTATION; DRUG EFFECT; EDITORIAL; FOLIC ACID BLOOD LEVEL; GENETIC RISK; GENOTYPE; HIGH RISK POPULATION; HUMAN; HYPERTENSION; PATIENT COMPLIANCE; PRIMARY PREVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK REDUCTION; UNITED STATES; VITAMIN SUPPLEMENTATION; MALE; STROKE;

ANTIHYPERTENSIVE AGENTS; ENALAPRIL; FOLIC ACID; HUMANS; HYPERTENSION; MALE; STROKE; VITAMIN B COMPLEX;

EID: 84927536743     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2015.1961     Document Type: Editorial

References (12)

1. Huo Y, Li J, Qin X, et al; CSPPT Investigators. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial. JAMA. doi:10.1001/jama.2015.2274.
2. Stampfer MJ, Malinow MR,WillettWC, et al. A prospective study of plasma homocyst(e)ine and risk ofmyocardial infarction in US physicians. JAMA. 1992;268(7):877-881.
3. Morrison HI, Schaubel D, Desmeules M, Wigle DT. Serum folate and risk of fatal coronary heart disease. JAMA. 1996;275(24):1893-1896.
4. Rimm EB, WillettWC, Hu FB, et al. Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA. 1998;279(5):359-364.
5. Selhub J, Jacques PF, Bostom AG, et al. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med. 1995;332(5):286-291.
6. Clarke R, Halsey J, Lewington S, et al; B-Vitamin Treatment Trialists' Collaboration. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med. 2010; 170(18):1622-1631.
7. Davey Smith G, Ebrahim S. Folate supplementation and cardiovascular disease. Lancet. 2005;366(9498):1679-1681.
8. Clarke R, Bennett DA, Parish S, et al; MTHFR Studies Collaborative Group. Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLoS Med. 2012;9(2):e1001177.
9. Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med. 1999;340(19):1449-1454.
10. HolmesMV, Newcombe P, Hubacek JA, et al. Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: ameta-analysis of genetic studies and randomised trials. Lancet. 2011; 378(9791):584-594.
11. Huo Y,Qin X, Wang J, et al. Efficacy of folic acid supplementation in stroke prevention: new insight from a meta-analysis. Int J Clin Pract. 2012;66(6): 544-551.
12. McLean E, de Benoist B, Allen LH. Review of the magnitude of folate and vitamin B12 deficiencies worldwide. Food Nutr Bull. 2008;29(2)(suppl):S38-S51.