Epitopes of HERV-Wenv induce antigen-specific humoral immunity in multiple sclerosis patients

Journal of Neuroimmunology

Volumn 280, Issue , 2015, Pages 66-68

  Mameli, Giuseppe ^a   Cossu, Davide ^a   Cocco, Eleonora ^b   Frau, Jessica ^b   Marrosu, Maria Giovanna ^b   Niegowska, Magdalena ^a   Sechi, Leonardo Antonio ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

HERV Wenv; Humoral response; IFN therapy

Indexed keywords

BETA INTERFERON; EPITOPE; PEPTIDE ANTIBODY; PROTEIN HERV; PROTEIN WENV; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; PEPTIDE; VIRUS ANTIBODY;

ADULT; ANTIBODY SPECIFICITY; ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HUMAN; HUMORAL IMMUNITY; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; TREATMENT RESPONSE; CASE CONTROL STUDY; ENDOGENOUS RETROVIRUS; IMMUNOLOGY; MIDDLE AGED;

ADULT; ANTIBODIES, VIRAL; CASE-CONTROL STUDIES; ENDOGENOUS RETROVIRUSES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; HUMANS; IMMUNITY, HUMORAL; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PEPTIDES;

EID: 84927511867     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2015.03.003     Document Type: Article

References (10)

1. Arru G., Leoni S., Pugliatti M., Mei A., Serra C., Delogu L.G., Manetti R., Dolei A., Sotgiu S., Mameli G. Natalizumab inhibits the expression of human endogenous retroviruses of the W family in multiple sclerosis patients: a longitudinal cohort study. Mult. Scler. 2014, 20:174-182.
2. Dolei A., Perron H. The multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease. J. Neurovirol. 2009, 15:4-13.
3. Frau J., Cossu D., Coghe G., Lorefice L., Fenu G., Melis M., Paccagnini D., Sardu C., Murru M.R., Tranquilli S., Marrosu M.G., Sechi L.A., Cocco E. Mycobacterium avium subsp. paratuberculosis and multiple sclerosis in Sardinian patients: epidemiology and clinical features. Mult. Scler. 2013, 19:1437-1442.
4. Mameli G., Serra C., Astone V., Castellazzi M., Poddighe L., Fainardi E., Neri W., Granieri E., Dolei A. Inhibition of multiple-sclerosis-associated retrovirus as biomarker of interferon therapy. J. Neurovirol. 2008, 14:73-77.
5. Mameli G., Cossu D., Cocco E., Masala S., Frau J., Marrosu M.G., Sechi L.A. EBNA-1 IgG titers in Sardinian multiple sclerosis patients and controls. J. Neuroimmunol. 2013, 264:120-122.
6. Mameli G., Cossu D., Cocco E., Masala S., Frau J., Marrosu M.G., Sechi L.A. Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis peptides are cross recognized by anti-myelin basic protein antibodies in multiple sclerosis patients. J. Neuroimmunol. 2014, 270:51-55.
7. Polman C.H., Reingold S.C., Banwell B., Clanet M., Cohen J.A., Filippi M., Fujihara K., Havrdova E., Hutchinson M., Kappos L., Lublin F.D., Montalban X., O'Connor P., Sandberg-Wollheim M., Thompson A.J., Waubant E., Weinshenker B., Wolinsky J.S. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann. Neurol. 2010, 69:292-302.
8. Rolland A., Jouvin-Marche E., Viret C., Faure M., Perron H., Marche P.N. The envelope protein of a human endogenous retrovirus-W family activates innate immunity through CD14/TLR4 and promotes Th1-like responses. J. Immunol. 2006, 176:7636-7644.
9. Ruprecht K., Gronen F., Sauter M., Best B., Rieckmann P., Mueller-Lantzsch N. Lack of immune responses against multiple sclerosis-associated retrovirus/human endogenous retrovirus W in patients with multiple sclerosis. J. Neurovirol. 2008, 14:143-151.
10. Sotgiu S., Mameli G., Serra C., Zarbo I.R., Arru G., Dolei A. Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis. Mult. Scler. 2010, 16:1248-1251.