메뉴 건너뛰기




Volumn 125, Issue 15, 2015, Pages 2435-2444

Lung parenchyma-derived IL-6 promotes IL-17A-dependent acute lung injury after allogeneic stem cell transplantation

(24)  Varelias, Antiopi a   Gartlan, Kate H a   Kreijveld, Ellen a   Olver, Stuart D a   Lor, Mary a   Kuns, Rachel D a   Lineburg, Katie E a   Teal, Bianca E a   Raffelt, Neil C a   Cheong, Melody a   Alexander, Kylie A a   Koyama, Motoko a   Markey, Kate A a   Sturgeon, Elise a,b   Leach, Justine a,b   Reddy, Pavan c   Kennedy, Glen A a,b   Yanik, Gregory A c   Blazar, Bruce R d   Tey, Siok Keen a,b   more..


Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 6; METHOTREXATE; STEROID; TUMOR NECROSIS FACTOR INHIBITOR; IMMUNOSUPPRESSIVE AGENT;

EID: 84927511163     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-07-590232     Document Type: Article
Times cited : (78)

References (43)
  • 2
    • 0027289278 scopus 로고
    • NHLBI workshop summary. Idiopathic pneumonia syndrome after bone marrow transplantation
    • Clark JG, Hansen JA, Hertz MI, Parkman R, Jensen L, Peavy HH. NHLBI workshop summary. Idiopathic pneumonia syndrome after bone marrow transplantation. Am Rev Respir Dis. 1993;147(6 pt 1):1601-1606.
    • (1993) Am Rev Respir Dis , vol.147 , Issue.6 , pp. 1601-1606
    • Clark, J.G.1    Hansen, J.A.2    Hertz, M.I.3    Parkman, R.4    Jensen, L.5    Peavy, H.H.6
  • 3
    • 79955518697 scopus 로고    scopus 로고
    • An official American Thoracic Society research statement: Noninfectious lung injury after hematopoietic stem cell transplantation: Idiopathic pneumonia syndrome
    • Panoskaltsis-Mortari A, Griese M, Madtes DK, et al American Thoracic Society Committee on Idiopathic Pneumonia Syndrome. An official American Thoracic Society research statement: noninfectious lung injury after hematopoietic stem cell transplantation: idiopathic pneumonia syndrome. Am J Respir Crit Care Med. 2011;183(9):1262-1279.
    • (2011) Am J Respir Crit Care Med , vol.183 , Issue.9 , pp. 1262-1279
    • Panoskaltsis-Mortari, A.1    Griese, M.2    Madtes, D.K.3
  • 4
    • 30344446001 scopus 로고    scopus 로고
    • The lung as a target organ of graft-versus-host disease
    • Yanik G, Cooke KR. The lung as a target organ of graft-versus-host disease. Semin Hematol. 2006;43(1):42-52.
    • (2006) Semin Hematol , vol.43 , Issue.1 , pp. 42-52
    • Yanik, G.1    Cooke, K.R.2
  • 5
    • 34547933330 scopus 로고    scopus 로고
    • IFNgamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract
    • Burman AC, Banovic T, Kuns RD, et al. IFNgamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract. Blood. 2007;110(3):1064-1072.
    • (2007) Blood , vol.110 , Issue.3 , pp. 1064-1072
    • Burman, A.C.1    Banovic, T.2    Kuns, R.D.3
  • 6
    • 48949089208 scopus 로고    scopus 로고
    • Interferon-gamma regulates idiopathic pneumonia syndrome, a Th17+CD4+ T-cell-mediated graft-versus-host disease
    • Mauermann N, Burian J, von Garnier C, et al. Interferon-gamma regulates idiopathic pneumonia syndrome, a Th17+CD4+ T-cell-mediated graft-versus-host disease. Am J Respir Crit Care Med. 2008;178(4):379-388.
    • (2008) Am J Respir Crit Care Med , vol.178 , Issue.4 , pp. 379-388
    • Mauermann, N.1    Burian, J.2    Von Garnier, C.3
  • 7
    • 79951677394 scopus 로고    scopus 로고
    • Fate mapping of IL-17-producing T cells in inflammatory responses
    • Hirota K, Duarte JH, Veldhoen M, et al. Fate mapping of IL-17-producing T cells in inflammatory responses. Nat Immunol. 2011;12(3):255-263.
    • (2011) Nat Immunol , vol.12 , Issue.3 , pp. 255-263
    • Hirota, K.1    Duarte, J.H.2    Veldhoen, M.3
  • 8
    • 84855546719 scopus 로고    scopus 로고
    • Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease
    • Koyama M, Kuns RD, Olver SD, et al. Recipient nonhematopoietic antigen-presenting cells are sufficient to induce lethal acute graft-versus-host disease. Nat Med. 2011;18(1):135-142.
    • (2011) Nat Med , vol.18 , Issue.1 , pp. 135-142
    • Koyama, M.1    Kuns, R.D.2    Olver, S.D.3
  • 9
    • 27644443729 scopus 로고    scopus 로고
    • NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs
    • Morris ES, MacDonald KP, Rowe V, et al. NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs. J Clin Invest. 2005;115(11):3093-3103.
    • (2005) J Clin Invest , vol.115 , Issue.11 , pp. 3093-3103
    • Morris, E.S.1    MacDonald, K.P.2    Rowe, V.3
  • 10
    • 1942425058 scopus 로고    scopus 로고
    • Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance
    • Morris ES, MacDonald KP, Rowe V, et al. Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance. Blood. 2004;103(9):3573-3581.
    • (2004) Blood , vol.103 , Issue.9 , pp. 3573-3581
    • Morris, E.S.1    MacDonald, K.P.2    Rowe, V.3
  • 11
    • 77955873442 scopus 로고    scopus 로고
    • Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma
    • Hill GR, Olver SD, Kuns RD, et al. Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma. Blood. 2010;116(5):819-828.
    • (2010) Blood , vol.116 , Issue.5 , pp. 819-828
    • Hill, G.R.1    Olver, S.D.2    Kuns, R.D.3
  • 12
    • 0029909099 scopus 로고    scopus 로고
    • An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin
    • Cooke KR, Kobzik L, Martin TR, et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood. 1996;88(8):3230-3239.
    • (1996) Blood , vol.88 , Issue.8 , pp. 3230-3239
    • Cooke, K.R.1    Kobzik, L.2    Martin, T.R.3
  • 13
    • 78751469023 scopus 로고    scopus 로고
    • Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation
    • Tawara I, Koyama M, Liu C, et al. Interleukin-6 modulates graft-versus-host responses after experimental allogeneic bone marrow transplantation. Clin Cancer Res. 2011;17(1):77-88.
    • (2011) Clin Cancer Res , vol.17 , Issue.1 , pp. 77-88
    • Tawara, I.1    Koyama, M.2    Liu, C.3
  • 14
    • 0030861750 scopus 로고    scopus 로고
    • Total body irradiation and acute graft-versus-host disease: The role of gastrointestinal damage and inflammatory cytokines
    • Hill GR, Crawford JM, Cooke KR, Brinson YS, Pan L, Ferrara JLM. Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. Blood. 1997;90(8):3204-3213.
    • (1997) Blood , vol.90 , Issue.8 , pp. 3204-3213
    • Hill, G.R.1    Crawford, J.M.2    Cooke, K.R.3    Brinson, Y.S.4    Pan, L.5    Ferrara, J.L.M.6
  • 15
    • 0034193057 scopus 로고    scopus 로고
    • The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: Rationale for the use of cytokine shields in allogeneic bone marrow transplantation
    • Hill GR, Ferrara JLM. The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood. 2000;95(9):2754-2759.
    • (2000) Blood , vol.95 , Issue.9 , pp. 2754-2759
    • Hill, G.R.1    Ferrara, J.L.M.2
  • 16
    • 0030982518 scopus 로고    scopus 로고
    • The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamide
    • Panoskaltsis-Mortari A, Taylor PA, Yaeger TM, et al. The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamide. J Clin Invest. 1997;100(5):1015-1027.
    • (1997) J Clin Invest , vol.100 , Issue.5 , pp. 1015-1027
    • Panoskaltsis-Mortari, A.1    Taylor, P.A.2    Yaeger, T.M.3
  • 17
    • 34547103280 scopus 로고    scopus 로고
    • Absence of donor T-cell-derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity
    • Borsotti C, Franklin AR, Lu SX, et al. Absence of donor T-cell-derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity. Blood. 2007;110(2):783-786.
    • (2007) Blood , vol.110 , Issue.2 , pp. 783-786
    • Borsotti, C.1    Franklin, A.R.2    Lu, S.X.3
  • 18
    • 84855406581 scopus 로고    scopus 로고
    • The IL-17 differentiation pathway and its role in transplant outcome
    • Serody JS, Hill GR. The IL-17 differentiation pathway and its role in transplant outcome. Biol Blood Marrow Transplant. 2012;18(suppl 1):S56-S61.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. S56-S61
    • Serody, J.S.1    Hill, G.R.2
  • 19
    • 0031913593 scopus 로고    scopus 로고
    • Interleukin 6 and its receptor: Ten years later
    • Hirano T. Interleukin 6 and its receptor: ten years later. Int Rev Immunol. 1998;16(3-4):249-284.
    • (1998) Int Rev Immunol , vol.16 , Issue.3-4 , pp. 249-284
    • Hirano, T.1
  • 20
    • 84862783824 scopus 로고    scopus 로고
    • Response patterns of cytokines/chemokines in two murine strains after irradiation
    • Zhang M, Yin L, Zhang K, et al. Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine. 2012;58(2):169-177.
    • (2012) Cytokine , vol.58 , Issue.2 , pp. 169-177
    • Zhang, M.1    Yin, L.2    Zhang, K.3
  • 21
    • 23344446570 scopus 로고    scopus 로고
    • Intestinal macrophages: Unique effector cells of the innate immune system
    • Smith PD, Ochsenbauer-Jambor C, Smythies LE. Intestinal macrophages: unique effector cells of the innate immune system. Immunol Rev. 2005;206:149-159.
    • (2005) Immunol Rev , vol.206 , pp. 149-159
    • Smith, P.D.1    Ochsenbauer-Jambor, C.2    Smythies, L.E.3
  • 22
    • 0036853910 scopus 로고    scopus 로고
    • Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ
    • Constant SL, Brogdon JL, Piggott DA, et al. Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ. J Clin Invest. 2002;110(10):1441-1448.
    • (2002) J Clin Invest , vol.110 , Issue.10 , pp. 1441-1448
    • Constant, S.L.1    Brogdon, J.L.2    Piggott, D.A.3
  • 23
    • 84878167904 scopus 로고    scopus 로고
    • IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation
    • Persson EK, Uronen-Hansson H, Semmrich M, et al. IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation. Immunity. 2013;38(5):958-969.
    • (2013) Immunity , vol.38 , Issue.5 , pp. 958-969
    • Persson, E.K.1    Uronen-Hansson, H.2    Semmrich, M.3
  • 24
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991;66(4):807-815.
    • (1991) Cell , vol.66 , Issue.4 , pp. 807-815
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 25
    • 0026575932 scopus 로고
    • The mechanism of action of cyclosporin A and FK506
    • Schreiber SL, Crabtree GR. The mechanism of action of cyclosporin A and FK506. Immunol Today. 1992;13(4):136-142.
    • (1992) Immunol Today , vol.13 , Issue.4 , pp. 136-142
    • Schreiber, S.L.1    Crabtree, G.R.2
  • 26
    • 0033698581 scopus 로고    scopus 로고
    • Manipulating immune responses with immunosuppressive agents that target NFAT
    • Kiani A, Rao A, Aramburu J. Manipulating immune responses with immunosuppressive agents that target NFAT. Immunity. 2000;12(4):359-372.
    • (2000) Immunity , vol.12 , Issue.4 , pp. 359-372
    • Kiani, A.1    Rao, A.2    Aramburu, J.3
  • 27
    • 84857124663 scopus 로고    scopus 로고
    • Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naive T cells into cytokine-producing mature T cells
    • Tsuda K, Yamanaka K, Kitagawa H, et al. Calcineurin inhibitors suppress cytokine production from memory T cells and differentiation of naive T cells into cytokine-producing mature T cells. PLoS One. 2012;7(2):e31465.
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e31465
    • Tsuda, K.1    Yamanaka, K.2    Kitagawa, H.3
  • 28
    • 84874429197 scopus 로고    scopus 로고
    • Cyclosporine A drives a Th17- and Th2-mediated posttransplant obliterative airway disease
    • Lemaître PH, Vokaer B, Charbonnier LM, et al. Cyclosporine A drives a Th17- and Th2-mediated posttransplant obliterative airway disease. Am J Transplant. 2013;13(3):611-620.
    • (2013) Am J Transplant , vol.13 , Issue.3 , pp. 611-620
    • Lemaître, P.H.1    Vokaer, B.2    Charbonnier, L.M.3
  • 29
    • 84925228691 scopus 로고    scopus 로고
    • Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: A phase 1/2 trial
    • Kennedy GA, Varelias A, Vuckovic S, et al. Addition of interleukin-6 inhibition with tocilizumab to standard graft-versus-host disease prophylaxis after allogeneic stem-cell transplantation: a phase 1/2 trial. Lancet Oncol. 2014;15(13):1451-1459.
    • (2014) Lancet Oncol , vol.15 , Issue.13 , pp. 1451-1459
    • Kennedy, G.A.1    Varelias, A.2    Vuckovic, S.3
  • 30
    • 3142652673 scopus 로고    scopus 로고
    • Donor-derived TNF-alpha regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation
    • Hildebrandt GC, Olkiewicz KM, Corrion LA, et al. Donor-derived TNF-alpha regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood. 2004;104(2):586-593.
    • (2004) Blood , vol.104 , Issue.2 , pp. 586-593
    • Hildebrandt, G.C.1    Olkiewicz, K.M.2    Corrion, L.A.3
  • 31
    • 4143105828 scopus 로고    scopus 로고
    • A role for tumor necrosis factor-alpha-mediated endothelial apoptosis in the development of experimental idiopathic pneumonia syndrome
    • Gerbitz A, Nickoloff BJ, Olkiewicz K, et al. A role for tumor necrosis factor-alpha-mediated endothelial apoptosis in the development of experimental idiopathic pneumonia syndrome. Transplantation. 2004;78(4):494-502.
    • (2004) Transplantation , vol.78 , Issue.4 , pp. 494-502
    • Gerbitz, A.1    Nickoloff, B.J.2    Olkiewicz, K.3
  • 32
    • 0034721091 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation
    • Cooke KR, Hill GR, Gerbitz A, et al. Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation. Transplantation. 2000;70(2):272-279.
    • (2000) Transplantation , vol.70 , Issue.2 , pp. 272-279
    • Cooke, K.R.1    Hill, G.R.2    Gerbitz, A.3
  • 33
    • 0034661959 scopus 로고    scopus 로고
    • Neutralization of tumor necrosis factor-alpha action delays but does not prevent lung injury induced by alloreactive T helper 1 cells
    • Clark JG, Mandac JB, Dixon AE, Martin PJ, Hackman RC, Madtes DK. Neutralization of tumor necrosis factor-alpha action delays but does not prevent lung injury induced by alloreactive T helper 1 cells. Transplantation. 2000;70(1):39-43.
    • (2000) Transplantation , vol.70 , Issue.1 , pp. 39-43
    • Clark, J.G.1    Mandac, J.B.2    Dixon, A.E.3    Martin, P.J.4    Hackman, R.C.5    Madtes, D.K.6
  • 34
    • 54049122250 scopus 로고    scopus 로고
    • The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation
    • Yanik GA, Ho VT, Levine JE, et al. The impact of soluble tumor necrosis factor receptor etanercept on the treatment of idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation. Blood. 2008;112(8):3073-3081.
    • (2008) Blood , vol.112 , Issue.8 , pp. 3073-3081
    • Yanik, G.A.1    Ho, V.T.2    Levine, J.E.3
  • 35
    • 84867395638 scopus 로고    scopus 로고
    • High-dose corticosteroids with or without etanercept for the treatment of idiopathic pneumonia syndrome after allo-SCT
    • Tizon R, Frey N, Heitjan DF, et al. High-dose corticosteroids with or without etanercept for the treatment of idiopathic pneumonia syndrome after allo-SCT. Bone Marrow Transplant. 2012;47(10):1332-1337.
    • (2012) Bone Marrow Transplant , vol.47 , Issue.10 , pp. 1332-1337
    • Tizon, R.1    Frey, N.2    Heitjan, D.F.3
  • 36
    • 84927649118 scopus 로고    scopus 로고
    • Competitive TNF inhibitor (ETANERCEPT) for the treatment of idiopathic pneumonia syndrome (IPS) following allogeneic stem cell transplantation (SCT). A Joint Pediatric Blood and Marrow Transplant Consortium (PBMTC) and Children's Oncology Group (COG) Study
    • Yanik G, Grupp S, Pulsipher MA, et al. Competitive TNF inhibitor (ETANERCEPT) for the treatment of idiopathic pneumonia syndrome (IPS) following allogeneic stem cell transplantation (SCT). A Joint Pediatric Blood and Marrow Transplant Consortium (PBMTC) and Children's Oncology Group (COG) Study. Biol Blood Marrow Transplant. 2013;19(supp 2):S111-S112.
    • (2013) Biol Blood Marrow Transplant , vol.19 , pp. S111-S112
    • Yanik, G.1    Grupp, S.2    Pulsipher, M.A.3
  • 37
    • 84899920388 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of a soluble tumor necrosis factor receptor: Enbrel (Etanercept) for the treatment of idiopathic pneumonia syndrome after allogeneic stem cell transplantation: Blood and Marrow Transplant Clinical Trials Network Protocol
    • Yanik GA, Horowitz MH, Weisdorf DJ, et al. Randomized, double-blind, placebo-controlled trial of a soluble tumor necrosis factor receptor: Enbrel (Etanercept) for the treatment of idiopathic pneumonia syndrome after allogeneic stem cell transplantation: Blood and Marrow Transplant Clinical Trials Network Protocol. Biol Blood Marrow Transplant. 2014;20(6):858-864.
    • (2014) Biol Blood Marrow Transplant , vol.20 , Issue.6 , pp. 858-864
    • Yanik, G.A.1    Horowitz, M.H.2    Weisdorf, D.J.3
  • 38
    • 70449494642 scopus 로고    scopus 로고
    • Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease
    • Yi T, Chen Y, Wang L, et al. Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood. 2009;114(14):3101-3112.
    • (2009) Blood , vol.114 , Issue.14 , pp. 3101-3112
    • Yi, T.1    Chen, Y.2    Wang, L.3
  • 39
    • 0035438384 scopus 로고    scopus 로고
    • Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation
    • Cavet J, Dickinson AM, Norden J, Taylor PR, Jackson GH, Middleton PG. Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantation. Blood. 2001;98(5):1594-1600.
    • (2001) Blood , vol.98 , Issue.5 , pp. 1594-1600
    • Cavet, J.1    Dickinson, A.M.2    Norden, J.3    Taylor, P.R.4    Jackson, G.H.5    Middleton, P.G.6
  • 40
    • 10344261473 scopus 로고    scopus 로고
    • Eurobank members. Genetic polymorphisms predicting the outcome of bone marrow transplants
    • Dickinson AM, Middleton PG, Rocha V, Gluckman E, Holler E; Eurobank members. Genetic polymorphisms predicting the outcome of bone marrow transplants. Br J Haematol. 2004;127(5):479-490.
    • (2004) Br J Haematol , vol.127 , Issue.5 , pp. 479-490
    • Dickinson, A.M.1    Middleton, P.G.2    Rocha, V.3    Gluckman, E.4    Holler, E.5
  • 41
    • 84861805352 scopus 로고    scopus 로고
    • Evaluation of published single nucleotide polymorphisms associated with acute GVHD
    • Chien JW, Zhang XC, Fan W, et al. Evaluation of published single nucleotide polymorphisms associated with acute GVHD. Blood. 2012;119(22):5311-5319.
    • (2012) Blood , vol.119 , Issue.22 , pp. 5311-5319
    • Chien, J.W.1    Zhang, X.C.2    Fan, W.3
  • 42
    • 84861819122 scopus 로고    scopus 로고
    • SNPs and GVHD prediction: Where to next?
    • Dickinson AM. SNPs and GVHD prediction: where to next? Blood. 2012;119(22):5066-5068.
    • (2012) Blood , vol.119 , Issue.22 , pp. 5066-5068
    • Dickinson, A.M.1
  • 43
    • 0032189103 scopus 로고    scopus 로고
    • The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
    • Fishman D, Faulds G, Jeffery R, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 1998;102(7):1369-1376.
    • (1998) J Clin Invest , vol.102 , Issue.7 , pp. 1369-1376
    • Fishman, D.1    Faulds, G.2    Jeffery, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.