Podocyte biology: Differentiation of parietal epithelial cells into podocytes

Nature Reviews Nephrology

Volumn 11, Issue 1, 2015, Pages 7-8

  Lazzeri, Elena ^a   Romagnani, Paola ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD133 ANTIGEN; CD24 ANTIGEN; COLECALCIFEROL; DEXAMETHASONE; MICRORNA; MICRORNA 193A; RETINOIC ACID; UNCLASSIFIED DRUG; WT1 PROTEIN;

CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; CHRONIC KIDNEY DISEASE; EPITHELIUM CELL; FOCAL GLOMERULOSCLEROSIS; GENE AMPLIFICATION; HUMAN; IMMUNE COMPLEX NEPHRITIS; KIDNEY BIOPSY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; SHORT SURVEY; STEM CELL; ANIMAL; CELL TRANSDIFFERENTIATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

ANIMALS; CELL TRANSDIFFERENTIATION; GENE EXPRESSION REGULATION; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; MICRORNAS; PODOCYTES;

EID: 84927175250     PISSN: 17595061     EISSN: 1759507X     Source Type: Journal    
DOI: 10.1038/nrneph.2014.218     Document Type: Short Survey

References (10)

1. Kriz, W. & Lemley, K. V. A potential role for mechanical forces in the detachment of podocytes and the progression of CKD. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2014030278.
2. Kietzmann, L. et al. MicroRNA-193a regulates the transdifferentiation of human parietal epithelial cells toward a podocyte phenotype. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2014020190.
3. Gebeshuber, C. A. et al. Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1. Nature Med. 19, 481-487 (2013).
4. Schell, C., Wanner, N. & Huber, T. B. Glomerular development-shaping the multi-cellular filtration unit. Semin. Cell Dev. Biol. http://dx.doi.org/10.1016/j.semcdb.2014.07.016.
5. Sagrinati, C. et al. Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. J. Am. Soc. Nephrol. 17, 2443-2456 (2006).
6. Ronconi, E. et al. Regeneration of glomerular podocytes by human renal progenitors. J. Am. Soc. Nephrol. 20, 322-332 (2009).
7. Benigni, A. et al. Inhibiting angiotensin-converting enzyme promotes renal repair by limiting progenitor cell proliferation and restoring the glomerular architecture. Am. J. Pathol. 179, 628-638 (2011).
8. Peired, A. et al. Proteinuria impairs podocyte regeneration by sequestering retinoic acid. J. Am. Soc. Nephrol. 24, 1756-1768 (2013).
9. Shankland, S. J., Smeets, B., Pippin J. W. & Moeller, M. J. The emergence of the glomerular parietal epithelial cell. Nature Rev. Nephrol. 10, 158-173 (2014).
10. Smeets, B. et al. Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis. J. Am. Soc. Nephrol. 20, 2593-2603 (2009).